Resistance of zwitterionic telomers accumulated on metal surfaces against nonspecific adsorption of proteins

Kitano, Hiromi; Kawasaki, Akio; Kawasaki, Hideaki; Morokoshi, Shinta

doi:10.1016/j.jcis.2004.08.157

Cited by 91 publications

(62 citation statements)

References 96 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…RDRP methods enable also the anchoring of polyzwitterions to surfaces by "grafting-through" [105] and "grafting-to" processes [193,203,[313][314][315][316][317]. In particular, the latter profits from the facile incorporation of reactive groups in special positions, e.g., in the center or at the ends of the polymers, that enable efficient attachment of the macromolecules onto the substrates.…”

Section: Synthesis By Chain Growth Polymerizationsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

View full text Add to dashboard Cite

Abstract:The structures and synthesis of polyzwitterions ("polybetaines") are reviewed, emphasizing the literature of the past decade. Particular attention is given to the general challenges faced, and to successful strategies to obtain polymers with a true balance of permanent cationic and anionic groups, thus resulting in an overall zero charge. Also, the progress due to applying new methodologies from general polymer synthesis, such as controlled polymerization methods or the use of "click" chemical reactions is presented. Furthermore, the emerging topic of responsive ("smart") polyzwitterions is addressed. The considerations and critical discussions are illustrated by typical examples.

show abstract

Section: Synthesis By Chain Growth Polymerizationsmentioning

confidence: 99%

Structures and Synthesis of Zwitterionic Polymers

2014

View full text Add to dashboard Cite

show abstract

“…The proteins attached to the PCMB brush might be smoothly detached from the brush, keeping their native structures. [51] …”

Section: Adsorption Of Proteins To the Polymer-brush-on-gold Colloid mentioning

confidence: 99%

“…[44] Besides it has been found that zwitterionic telomer brushes (PolyMPC, PolySPB, and PolyCMB) resist against non-specific adsorption of proteins by using cyclic voltammetry (CV) and LSPR absorption spectroscopy. [51] In a recent study, it was reported that a carboxybetaine polymer grafted on a glass substrate highly resists against the protein and cell adsorption. [52] Meanwhile, atom transfer radical polymerization (ATRP) is categorized in living radical polymerizations, which can be applied to a wide variety of monomers, varying a topology of polymer (linear, branched, etc.)…”

Section: Introductionmentioning

confidence: 99%

Carboxybetaine Polymer‐Protected Gold Nanoparticles: High Dispersion Stability and Resistance against Non‐Specific Adsorption of Proteins

Matsuura

Ohno

Kagaya

et al. 2007

Macro Chemistry & Physics

Self Cite

View full text Add to dashboard Cite

Abstract1‐Carboxy‐N,N‐dimethyl‐N‐(2′‐methacryloyloxyethyl)methanaminium inner salt (CMB) was polymerized by ATRP initiated with a disulfide difunctionalized by 2‐bromoisobutyryl groups. The disulfide‐carrying carboxybetaine polymer (DT‐PCMB) was used for the preparation of PCMB‐protected gold nanoparticles (PCMB‐AuNPs) obtained by the reduction of hydrogen tetrachloroaurate (HAuCl4) in the presence of the DT‐PCMB of different molecular weights at different molar ratios of DT‐PCMB and HAuCl4. The sizes of gold cores in the PCMB‐AuNPs tended to increase upon decreasing concentration and molecular weight of the DT‐PCMB. The PCMB‐AuNPs possessed a high dispersion stability, and showed a resistance against non‐specific adsorption of proteins (bovine serum albumin, human serum albumin, lysozyme, and cytochrome c). Therefore, DT‐PCMB is a quite suitable stabilizing ligand to prepare inert AuNPs and the PCMB‐AuNPs will be useful in biomedical applications.magnified image

show abstract

“…Our group has recently found by using localized surface plasmon resonance (LSPR) spectroscopy that a polymer brush of carboxybetaine was highly resistant to non-specific adsorption of proteins. [17,18] Other research groups also have reported that modification of solid surfaces with carboxybetaine polymers reduced protein adsorption and platelet adhesion. [19,20] However, the biocompatibility (in other words, anti-biofouling property) of ''carboxybetaine copolymers'' has not been evaluated in detail.…”

Section: Introductionmentioning

confidence: 99%

Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Tada¹,

Inaba²,

Mizukami³

et al. 2008

Macromolecular Bioscience

Self Cite

View full text Add to dashboard Cite

The resistance of random copolymers of BMA and CMB against biofouling was evaluated. The amount of proteins adsorbed onto the CMB copolymers was smaller than that onto other polymers (non-ionic polymers and copolymers of ordinary ionic monomers and BMA) and decreased with an increase in the content of CMB residues. Furthermore, there was a dramatic decrease in the number of cells (platelets and fibroblasts) that adhered to the CMB copolymers compared with that to other polymers. In contrast with this, CMB copolymers were slightly perturbative to both complement and coagulation systems. However, the overall results suggest that zwitterionic moieties are effective for making polymer materials biocompatible due to their excellent anti-biofouling property.

show abstract

Resistance of zwitterionic telomers accumulated on metal surfaces against nonspecific adsorption of proteins

Cited by 91 publications

References 96 publications

Structures and Synthesis of Zwitterionic Polymers

Structures and Synthesis of Zwitterionic Polymers

Carboxybetaine Polymer‐Protected Gold Nanoparticles: High Dispersion Stability and Resistance against Non‐Specific Adsorption of Proteins

Anti‐Biofouling Properties of Polymers with a Carboxybetaine Moiety

Contact Info

Product

Resources

About