Resistance to drug by different isolates Trypanosoma evansi in China

Zhou, Jinlin; Shen, Jie; Liao, Dangjin; Zhou, Yongzhi; Lin, Jiaojiao

doi:10.1016/j.actatropica.2004.02.002

Cited by 36 publications

(28 citation statements)

References 11 publications

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“…Vaccine against T. evansi infection is not currently available. While Berenil ® demonstrated higher effectiveness than Trypamidium ® in this study, other trypanocidal drugs have been found to be ineffective due to drug resistance of the parasite and/or toxicity to the animal host [7,8,12,16]. Therefore, alternative strategies should focus extensively on vector control activities.…”

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confidence: 99%

“…In Vietnam, 2 of the most common drugs prescribed are Trypamidium ® (isometamidium chloride) from Merial, France and Berenil ® (diminazene aceturate) from Intervet, Germany. According to McDermott et al [11] and Zhou et al [16], extensive use of these 2 compounds has led to drug resistance and treatment failure in several countries. Thus, there is a need to evaluate current surra treatment by assessing the effectiveness of Trypamidium ® and Berenil ® under in vivo conditions.…”

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confidence: 99%

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Seroprevalence of <i>Trypanosoma evansi</i> Infection in Water Buffaloes from the Mountainous Region of North Vietnam and Effectiveness of Trypanocidal Drug Treatment

Nguyen

Pham

et al. 2013

The Journal of Veterinary Medical Science

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ABSTRACT. Water buffalo (WB) is an important domestic animal in Vietnam. This study utilized a card agglutination test to investigate seroprevalence of surra in WB population. Sera were collected from 585 WB from 4 different regions in Cao Bang and Thai Nguyen Provinces. Among them, 131 samples (22.4%) were positive for surra. The highest prevalence (24.6%) was found among 3 to 5 years old WB. Buffaloes less than 3 years old had the lowest prevalence (15.6%). Among 27 abortion cases, 9 WB (33.3%) were surra positive. For treatment of surra, Berenil ® demonstrated a 100% cure rate, while that of Trypamidium ® was only 40%. Our findings suggest that the current control strategy has not succeeded in reducing prevalence of surra in Vietnam.

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Seroprevalence of <i>Trypanosoma evansi</i> Infection in Water Buffaloes from the Mountainous Region of North Vietnam and Effectiveness of Trypanocidal Drug Treatment

Nguyen

Pham

et al. 2013

The Journal of Veterinary Medical Science

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“…Such type of correlated study on T. evansi infection in horses has not yet been done earlier in India. If we consider the development of drug resistance is a cause of reinfection, then repeated use of the same medicine might be the cause of development of drug resistance against T. evansi infection and development of drug resistance is now a severe and increasing problem in trypanosomosis (Zhou et al 2004;Witola et al 2005).…”

Section: Discussionmentioning

confidence: 99%

Endemic status of Trypanosoma evansi infection in a horse stable of eastern region of India – a field investigation

Laha

Sasmal

2007

Trop Anim Health Prod

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Diagnosis of Trypanosoma evansi infection in a horse stable of Eastern Region of India on the basis of examination of Giemsa stained blood smears have been done. A high percentage (12.74%) of horses of this stable was found suffering from T evansi infection. This high prevalence of T evansi in horses, in this area could be considered as an alarming situation which has never been explored previously in horses of Eastern Region of India. After a period of 2 months and 18 days of treatment with quinapyramine sulphate and quinapyramine chloride, reinfection with T evansi in treated horses of this stable were noticed. Clinical signs of affected horses and possible causes of reinfection have been discussed.

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“…However, during an investigation of VSGs expressed by T. evansi from domesticated animals in Malaysia, two VSGs, VSG Selangor1 and VSG Selangor2 (EMBL accession numbers AM497933 and AM497934), were found to have almost identical (389/390) N-terminal domains but different C-terminal domains; Selangor1 is a type 1 and Selangor2 is a type 2 VSG. VSG Selangor1 is Ͼ99% identical to a T. evansi VSG isolated from a buffalo in Anhui province of China 17 years previously (EMBL accession number AAS66654) (25). An alignment of the two Malaysian VSGs (Fig.…”

Section: Resultsmentioning

confidence: 99%

Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein

Jones

Nietlispach

Sharma³

et al. 2008

Journal of Biological Chemistry

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The cell surface of African trypanosomes is covered by a densely packed monolayer of a single protein, the variant surface glycoprotein (VSG). The VSG protects the trypanosome cell surface from effector molecules of the host immune system and is the mediator of antigenic variation. The sequence divergence between VSGs that is necessary for antigenic variation can only occur within the constraints imposed by the structural features necessary to form the monolayer barrier. Here, the structures of the two domains that together comprise the C-terminal di-domain of VSG ILTat1.24 have been determined. The first domain has a structure similar to the single C-terminal domain of VSG MITat1.2 and provides proof of structural conservation in VSG C-terminal domains complementing the conservation of structure present in the N-terminal domain. The second domain, although based on the same fold, is a minimized version missing several structural features. The structure of the second domain contains the C-terminal residue that in the native VSG is attached to a glycosylphosphatidylinositol (GPI) anchor that retains the VSG on the external face of the plasma membrane. The solution structures of this domain and a VSG GPI glycan have been combined to produce the first structure-based model of a GPI-anchored protein. The model suggests that the core glycan of the GPI anchor lies in a groove on the surface of the domain and that there is a close association between the GPI glycan and protein. More widely, the GPI glycan may be an integral part of the structure of other GPI-anchored proteins.

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Resistance to drug by different isolates Trypanosoma evansi in China

Cited by 36 publications

References 11 publications

Seroprevalence of <i>Trypanosoma evansi</i> Infection in Water Buffaloes from the Mountainous Region of North Vietnam and Effectiveness of Trypanocidal Drug Treatment

Seroprevalence of <i>Trypanosoma evansi</i> Infection in Water Buffaloes from the Mountainous Region of North Vietnam and Effectiveness of Trypanocidal Drug Treatment

Endemic status of Trypanosoma evansi infection in a horse stable of eastern region of India – a field investigation

Structure of a Glycosylphosphatidylinositol-anchored Domain from a Trypanosome Variant Surface Glycoprotein

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