Resistance to Erythromycin in Group A Streptococci

Seppälä, Helena; Nissinen, A; Järvinen, Helinä; Huovinen, Saara; Henriksson, Taisto; Herva, Elja; Holm, Stig E.; Jahkola, M; Katila, Marja–Leena; Klaukka, Timo; Kontiainen, Sirkka; Liimatainen, Oili; Oinonen, S; Passi-Metsomaa, Leena; Huovinen, Pentti

doi:10.1056/nejm199201303260503

Cited by 321 publications

(169 citation statements)

References 27 publications

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“…Our results show that a few M types were responsible for up to 85% of the erythromycinresistant isolates, suggesting that few clones caused this phenomenon. This hypothesis was supported by the fact that the M phenotype was the most common resistance mechanism, a feature previously reported by other authors (20,23). However, genetic divergence among strains sharing the same emm gene sequence has been reported (5,6,17,29).…”

Section: Vol 41 2003 Emm Typing and Erythromycin Resistance Of S Psupporting

confidence: 63%

“…Resistance to erythromycin remained at low levels among S. pyogenes in most countries of the world (14); however, in the last years, a significant increase in erythromycin-resistant isolates in different countries has been reported (15,20,22,23). In most of these studies, resistance to erythromycin was caused by a few clones and the mechanisms of resistance were mainly based on the presence of an active drug efflux by pumps encoded by the gene mefA (M phenotype) that take out of the cells 14-and 15-membered macrolides (25).…”

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confidence: 99%

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Survey of emm Gene Sequences from Pharyngeal Streptococcus pyogenes Isolates Collected in Spain and Their Relationship with Erythromycin Susceptibility

et al. 2003

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We conducted a nationwide survey of the variable 5 emm (M protein gene) sequences from 614 pharyngeal Streptococcus pyogenes isolates susceptible (299 isolates) and resistant (315 isolates) to erythromycin that were isolated in Spain from 1996 to 1999. Almost 98% of these isolates had emm sequences in agreement with previously recorded M antigen association. We only identified a new 5 emm sequence in 17 isolates. Nine different emm types accounted for 85% of the S. pyogenes isolates susceptible to erythromycin. By contrast, only 3 emm types accounted for 70% of the erythromycin-resistant isolates. Further characterization of these isolates by ribotyping and pulsed-field gel electrophoresis indicated that high frequency of erythromycin resistance in Spain is due to few clones.

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Section: Vol 41 2003 Emm Typing and Erythromycin Resistance Of S Psupporting

confidence: 63%

mentioning

confidence: 99%

Survey of emm Gene Sequences from Pharyngeal Streptococcus pyogenes Isolates Collected in Spain and Their Relationship with Erythromycin Susceptibility

et al. 2003

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“…However, most of the gramnegative bacteria isolated were resistant to macrolides. These results were similar to the study reported by Seppala et al 24 The resistance shown to macrolides might be due to frequent and large administration. In addition, they were used in prophylaxis treatment.…”

Section: Discussionsupporting

confidence: 92%

Distribution of Multi-Resistant Bacterial Isolates from Clinical Specimens in a Hospital Environment of Kingdom of Saudi Arabia

Alavudeen¹,

Easwaran²,

Asiri³

et al. 2017

JYP

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“…29 In 1992, Seppala et al, reported a high rate of erythromycin resistance(>45%) in Finland. 30 High frequencies of Erythromycin resistance have also been reported from Spain (21.3%), Italy (22.6%), Greece (24%), France (22.4%), Portugal (26.6%)and USA(32%). 31 Although there have been recent isolated reports of macrolide resistance in the United States, there is no evidence that this is widespread at the present time, as less than 5% of Group A streptococci isolates in the United States have been shown to be resistant to Erythromycin.…”

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confidence: 97%

4. Pharyngeal carriage of Group A streptococci among school children

Mukundan¹,

Vijayakumar²

2017

JIMD

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Abstract:Objectives: The aims of the study were to determine the pharyngeal carriage rate of Group A streptococci among school children at Thrissur, Kerala and to determine the antibiotic sensitivity pattern of the above isolates. Materials and methods: Throat swabs were collected from a total of 260 asymptomatic children(130 each from rural and urban areas) of eighth and ninth standard classes during a period between July 2012 and July 2013. Presumptively identified Group A Streptococci (GAS/Streptococcus pyogenes) were serogrouped by agglutination tests using specific antisera. Antibiotic sensitivity was performed by disc diffusion method following CLSI guidelines. Results: The GAS carriage rate noted in the study was 23.1%. Carriage distribution was found to be independent of age, sex and locality with more number of cases during winter season. All the isolates were found to be sensitive to Penicillin and Vancomycin. Five isolates each were found to be resistant to Erythromycin and Clindamycin respectively. Inducible Clindamycin resistance was demonstrated in three of them. GAS was isolated from the throat swab of one child with past history of joint pains and another child with past history of skin infection-both of them presently had findings of heart disease. Conclusion: When screened and appropriately treated with antibiotics, carriers can be prevented from spreading streptococcal infections in the school environment and the community. Combined efforts by clinicians, community health personnel and clinical microbiologists are required for the early detection and control of streptococcal infections. .

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Resistance to Erythromycin in Group A Streptococci

Cited by 321 publications

References 27 publications

Survey of emm Gene Sequences from Pharyngeal Streptococcus pyogenes Isolates Collected in Spain and Their Relationship with Erythromycin Susceptibility

Survey of emm Gene Sequences from Pharyngeal Streptococcus pyogenes Isolates Collected in Spain and Their Relationship with Erythromycin Susceptibility

Distribution of Multi-Resistant Bacterial Isolates from Clinical Specimens in a Hospital Environment of Kingdom of Saudi Arabia

4. Pharyngeal carriage of Group A streptococci among school children

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