Resistance Training and Glycogen Content in Ovariectomized Rats

Abstract

The aim of the present study was to investigate the effects of resistance training on glycogen content and muscle cross-sectional area (CSA) in ovariectomized rats. Wistar rats were divided into: sedentary; ovariectomized sedentary; resistance trained; and ovariectomized resistance trained. In the 12-week resistance training, the animals climbed a 1.1 m vertical ladder, 3 days per week, with 4-8 climbs. Cardiac, liver and muscle glycogen content was determined. After the 12-week resistance training period there was a higher hepatic and muscle glycogen content in the resistance training group compared with the other groups (p<0.01). CSA was higher in soleus for the resistance trained, ovariectomized resistance trained and sedentary compared with ovariectomized sedentary (p<0.05). Ovariectomy attenuated the increase in liver and muscle glycogen content, while soleus muscle cross-sectional area increased with resistance training, even in ovariectomized rats. Resistance training could be an important exercise to increase muscle function in situations of reduced estrogen and progesterone.

Pitavastatin ameliorated the progression of steatohepatitis in ovariectomized mice fed a high fat and high cholesterol diet

“…These data were similar to those in our previous study . In OVX rodent models, hepatic glycogen contents were reported to decrease . Overnight fasting may induce further decrease in hepatic glycogen contents in OVX‐HFHC mice, and resulted in lower fasting serum glucose levels in this study.…”

Effects of ovariectomy and resistance training on oxidative stress markers in the rat liver

“…The conversion of xanthine dehydrogenase (XD) into xanthine oxidase (XO) is among the mechanisms involved in the induction of oxidative damage in the liver during exercise. XO reduces O 2 instead of NADP + , thereby producing superoxide ions (O 2 • ) (4). Da Silva et al (36) investigated the effects of different physical exercise protocols on OS markers in murine livers and found that continuous running and downhill running for 45 min daily, 5 days/week for 8 weeks, decreased the lipid peroxidation levels, as assessed by TBARS.…”

“…Menopause (ovariectomy in animals) is associated with increased food intake and body weight, metabolic dysfunction, loss of bone mineral density, diabetes, impairment of muscle function, and increased inflammatory markers and oxidative stress (OS) (1-4). OS may result in lipid peroxidation of cell membranes, damage to proteins, and DNA and stellate cell activation.…”

The effects of strength, aerobic, and concurrent exercise on skeletal muscle damage in rats

“…Because the rats had to climb the ramp with a load attached to a steel cable connected to a plastic belt surrounding the animal's body, the eccentric component during the strength exercise was minimal, which may have led to a minor impact on muscle damage compared with the aerobic exercise protocol. Nevertheless, there are other resistance training protocols for rats that have the same limitation of the eccentric phase of the movement . We only assessed the gastrocnemius muscle.…”

“…Nevertheless, there are other resistance training protocols for rats that have the same limitation of the eccentric phase of the movement. 29,30 We only assessed the gastrocnemius muscle. Thus, the results may have limited applicability to other muscles because of the predominance of type II muscle fibers.…”