Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity

Hira, Tohru; Suto, Ryoya; Kishimoto, Yuka; Kanahori, Sumiko; Hara, Hiroshi

doi:10.1007/s00394-017-1381-7

Cited by 37 publications

(31 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Rats were divided into three groups (n 8-9/group) to have comparable body weight, glucose and GLP-1 levels based on measurements the day prior to starting test diet feeding and Ex9 administration. The control group was fed a control diet with continuous saline administration, the high-fat/high-sucrose (HFS) group was fed a HFS diet (30 % fat and 40 % sucrose, shown in Table 1) (18,25) with continuous saline administration and the Ex9 group was also fed the HFS diet with continuous Ex9 administration for 5 weeks. Body weight and food intake were measured every 2 d. All experimental animal procedures were approved by the Hokkaido University Animal Committee, and animals were maintained in accordance with the Hokkaido University guidelines for the care and use of laboratory animals.…”

Section: Animals and Dietsmentioning

confidence: 99%

Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats

2019

Self Cite

View full text Add to dashboard Cite

Glucagon-like peptide-1 (GLP-1) is an incretin hormone that regulates postprandial glycaemic response by enhancing insulin secretion. We previously demonstrated that the postprandial GLP-1 response was enhanced during the development of diet-induced obesity in rats. However, the physiological relevance of the enhanced GLP-1 response remained unclear. We aimed to determine the role of endogenous GLP-1 during obesity development. Male Sprague–Dawley rats were given either a control diet or a high-fat/high-sucrose (HFS, 30 % fat and 40 % sucrose, weight basis) diet with or without continuous administration of the GLP-1 receptor antagonist, exendin (9–39) (Ex9, 100 µg/d), for 5 weeks. Meal tolerance tests (MTT) were performed to assess postprandial glucose, insulin and GLP-1 responses to a liquid diet administration (15 kcal (63 kJ)/10 ml per kg body weight) every 2 weeks. The AUC of postprandial glucose in the HFS group was similar to the control group in both MTT (P = 0·9665 and P = 0·3475, respectively), whereas AUC of postprandial GLP-1 (after 4 weeks,P = 0·0457) and of insulin (after 2 and 4 weeks, P = 0·0486 and P = 0·0110) was higher in the HFS group compared with the control group. In the Ex9 group, AUC of postprandial glucose (P = 0·0297 and P = 0·0486) was higher along with a lower insulin response compared with the HFS group (P = 0·0564 and P = 0·0281). These results suggest that enhancement of the postprandial GLP-1 response during obesity development has a role in maintaining a normal postprandial glycaemic response. Hence, enhancing endogenous GLP-1 secretion by certain materials could be a potential target for prevention of glucose intolerance.

show abstract

Section: Animals and Dietsmentioning

confidence: 99%

Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats

2019

Self Cite

View full text Add to dashboard Cite

show abstract

“…A negative association between the weight gain and the amount of sample intake was observed in Table 1 . Adequate intake of dietary fibers, such as FOS and RMD, has been reported to be capable of suppressing the weight increase even with high dietary energy consumption [ 14 , 15 ].…”

Section: Resultsmentioning

confidence: 99%

Inclusion of Fructooligosaccharide and Resistant Maltodextrin in High Fat Diets Promotes Simultaneous Improvements on Body Fat Reduction and Fecal Parameters

Kao

Chang

et al. 2018

Molecules

View full text Add to dashboard Cite

This study investigated the effects of incorporating a mixture of fructooligosaccharide (FOS) and resistant maltodextrin (RMD) at a ratio of 1:2 on body fat accumulation and fecal bacterial parameters in rats. Our results indicated that high dietary fat consumption might effectively (p < 0.05) increase body fat, but consequently inducing a significantly (p < 0.05) higher growth of C. perfringens and retarded growth (p < 0.05) of the Bifidobacterium spp. in the large intestine. As compared with the high fat control, an incorporation of the FOS and RMD mixture at a high dose (0.97 and 1.94 g/kg body weight, respectively) could result in a significant (p < 0.05) reduction in feed efficiency (−16%), total visceral fat (−17.4%), non-visceral fat levels (−20.3%), and total body fat (−19.2%). Furthermore, feeding the FOS and RMD mixture at a high dose was capable to counter the above undesirable impacts by reducing the C. perfringens count (−14.8%) and increasing the total Bifidobacterium count (134.4%) and total fecal short chain fatty acids (195.4%). A supplementation of adequate amount of FOS and RMD might confer a concreted solution to the obesity and deteriorated fecal bacteria profiles due to high fat consumption.

show abstract

“…The HFS diet contained 30% wt/wt fat and 40% wt/wt sucrose. 11,27) All diets contained 65 g/kg of fiber. DFA III, raffinose (Raf), and FOS were supplemented in the diet at doses of 30 g/kg diet (3%) by replacing 15 g of cellulose and 15 g of sucrose.…”

Section: Animals and Dietsmentioning

confidence: 99%

“…Anti-obesity effects of resistant maltodextrin and inulin-type fructans including fructooligosaccharides (FOS or OFS) have been demonstrated in animal and human studies. [5][6][7][8][9][10][11] Fermentable fibers promote production of short chain fatty acids (SCFAs), and SCFAs stimulate secretion and production of gut hormones such as glucagon like peptide-1 (GLP-1) and peptide YY (PYY) in the distal gut. These factors affect glucose, lipid, and energy metabolisms.…”

mentioning

confidence: 99%

Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet

Hira

Yanagihara

Koga

et al. 2017

Bioscience, Biotechnology, and Biochemistry

Self Cite

View full text Add to dashboard Cite

We investigated the effects of dietary supplementation of difructose anhydride III (DFA III), raffinose (Raf), and fructooligosaccharides (FOS) on diet-induced obesity development. Male rats were fed normal or high-fat and high-sucrose (HFS) diet, with or without supplementing (3%) DFA III, Raf, or FOS, for 8 or 5 weeks. Supplementing DFA III to the HFS diet decreased energy intake compared to the non-supplemented HFS diet. Accordingly, body weight gain and fat accumulation reduced in DFA III-fed rats. Cecal acetate production and plasma glucagon-like peptide-1 (GLP-1) and peptide-YY (PYY) were elevated in DFA III-fed rats, while Raf and FOS partially affected these parameters. These results demonstrate that DFA III has suppressive effect on excessive energy intake driven by the palatable obesogenic diet, possibly due to combined effects of increased anorexigenic factors such as cecal acetate production and GLP-1/PYY secretion.

show abstract

Resistant maltodextrin or fructooligosaccharides promotes GLP-1 production in male rats fed a high-fat and high-sucrose diet, and partially reduces energy intake and adiposity

Abstract: The physiological dose of a prebiotic fiber promptly (within 8 days) promotes GLP-1 production in rats fed an obesogenic diet, which would help to prevent excess energy intake and fat accumulation.

Cited by 37 publications

References 57 publications

Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats

Enhanced postprandial glucagon-like peptide-1 secretion during obesity development has a protective role against glucose intolerance induction in rats

Inclusion of Fructooligosaccharide and Resistant Maltodextrin in High Fat Diets Promotes Simultaneous Improvements on Body Fat Reduction and Fecal Parameters

Impact of difructose anhydride III, raffinose, and fructooligosaccharides on energy intake, gut hormones, and cecal fermentation in rats fed a high-fat and high-sucrose diet

Contact Info

Product

Resources

About