RESISTENSI <em>Klebsiella</em> sp TERHADAP MEROPENEM DI RSUD PROF. DR. MARGONO SOEKARJO PURWOKERTO

Abstract

Resistant Gram-negative bacteria, particularly Klebsiella sp., has become a serious problem in hospitals as one of the main causes of nosocomial infections spread through urine catheterization. Infections of Klebsiella sp. producing extended-spectrum beta-lactamase (ESBL) can lead to significant economic and clinical negative outcome. This study was aimed to determine the sensitivity of ESBL Klebsiella sp. against meropenem as a cause of nosocomial infections in Prof. Dr. Margono Soekarjo hospital. This research obtained urine samples from the urinary catheter of patients hospitalized for at least two days in the surgical ward and intensive care unit. ESBL examination conducted by the initial screen test, meanwhile, sensitivity test to meropenem done by using disk diffusion test. Among the 40 patients examined in this study 7.5% isolates were Klebsiella sp-positive. This research identified five percent of the total patients as ESBL positive with the level of sensitivity against meropenem was revealed as resistant.

Identification of the CTX-M Gene in Klebsiella Pneumoniae Producing Esbls in Uti Patients at a Private Hospital in Purwokerto, Banyumas Regency, Central Java - Cross Sectional Study

“…A previous study conducted at the Government Hospital in the Banyumas Regency, Central Java Indonesia, reported that 2 out of 40 Klebsiella pneumoniae analyzed were resistant to antibiotics (Afifah et al, 2017). These bacteria contribute to healthcare-associated illnesses and are the most frequent cause of urinary tract infections in hospital (Musdalipah, 2018).…”

“…Antibiotic resistance, often referred to as the alarming bacteria, is a life-threatening problem in many regions of the world (Afifah et al, 2017). Antibiotic resistance is predicted to kill 10 million population worldwide by 2050, with 4.7 million dying in Asia if the problem is not addressed.…”

Antibiotic resistance of biofilm-producing bacteria from sepsis patients in Prof. Dr. Margono Soekarjo Hospital, Purwokerto, Central Java

“…12 Furthermore, in Margono Soekarjo General Hospital, the resistance of Klebsiella to meropenem was reported. 13 Antibiotic resistance is a primary cause of antibiotic therapy failure in patients with sepsis and septic shock, raising the mortality rate in hospitals. Biofilm formation by sepsis-causing bacteria is another factor that contributes to the ineffectiveness of sepsis patients' treatment.…”