Resistin concentration and gestational diabetes: a systematic review of the literature

Lobo, Thalita Frutuoso; Torloni, Maria Regina; Gueuvoghlanian-Silva, Bárbara Yasmin; Mattar, Rosiane; Daher, Sílvia

doi:10.1016/j.jri.2012.10.004

Cited by 35 publications

(27 citation statements)

References 36 publications

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“…Reports on the levels of circulating resistin found in individuals with obesity and T2DM is controversial [38], but it is clear that resistin is associated with reduced insulin sensitivity [39], [40]. Consequently, our finding that resistin levels were increased in WD fed mice is consistent with our observation that these mice were also hyperinsulinemic.…”

Section: Discussionsupporting

confidence: 91%

Effects of the Use of Assisted Reproductive Technologies and an Obesogenic Environment on Resistance Artery Function and Diabetes Biomarkers in Mice Offspring

et al. 2014

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Maternal obesity affects the incidence of cardiovascular disease and diabetes in offspring. Also the use of assisted reproductive technologies (ART) has been associated with cardiovascular deficiencies in offspring. Obese women often suffer from infertility and use ART to achieve a pregnancy, but the combined effects of maternal obesity and ART on cardiovascular health and incidence of diabetes in the offspring is not known. Here, we report the effects of the use of ART within an obesogenic environment, consisting of feeding a western diet (WD) to dams and offspring, on resistance artery function and presence of diabetes biomarkers in juvenile mice offspring. Our results indicate that WD and ART interacted to induce endothelial dysfunction in mesenteric resistance arteries isolated from 7-week-old mice offspring. This was determined by presence of a reduced acetylcholine-induced dilation compared to controls. The arteries from these WD-ART mice also had greater wall cross-sectional areas and wall to lumen ratios indicative of vascular hypertrophic remodeling. Of the diabetes biomarkers measured, only resistin was affected by a WD×ART interaction. Serum resistin was significantly greater in WD-ART offspring compared to controls. Diet and sex effects were observed in other diabetes biomarkers. Our conclusion is that in mice the use of ART within an obesogenic environment interacts to favor the development of endothelial dysfunction in the resistance arteries of juvenile offspring, while having marginal effects on diabetes biomarkers.

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Section: Discussionsupporting

confidence: 91%

Effects of the Use of Assisted Reproductive Technologies and an Obesogenic Environment on Resistance Artery Function and Diabetes Biomarkers in Mice Offspring

et al. 2014

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“…These findings were unexpected as resistin and PAI‐1 have been positively associated with obesity, insulin resistance and inflammation . However, definitive conclusions from previous studies of these cytokines in GDM remain elusive as increased, decreased or unchanged concentrations have all been reported . It is possible that the observed variability in previous reports reflects differing gestational week of blood sampling or perhaps associated effects of labour on maternal results.…”

Section: Discussionmentioning

confidence: 98%

“…25 However, definitive conclusions from previous studies of these cytokines in GDM remain elusive as increased, decreased or unchanged concentrations have all been reported. 12,[26][27][28] It is possible that the observed variability in previous reports reflects differing gestational week of blood sampling or perhaps associated effects of labour on maternal results. Further, maternal adipocytokine results indicate that maternal age and pre-pregnancy BMI may influence PAI-1 outcomes.…”

Section: Discussionmentioning

confidence: 99%

Maternal, umbilical arterial and umbilical venous 25‐hydroxyvitamin D and adipocytokine concentrations in pregnancies with and without gestational diabetes

McManus

Summers

Vrijer

et al. 2013

Clinical Endocrinology

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SummaryObjective Gestational diabetes mellitus (GDM) has been associated with inflammation as well as Vitamin D insufficiency. While Vitamin D has anti-inflammatory properties, relationships between Vitamin D and inflammatory markers remain unexplored in GDM. Therefore, this case--control study investigated adipocytokine and Vitamin D [25(OH)D] concentrations and correlations in GDM and control women, as well as their neonates. Design/Participants/Measurements seventy-three women participated: 36 GDM and 37 controls. Maternal samples were drawn at 31 weeks. Umbilical arterial and venous samples were collected at birth. 25(OH)D and adipocytokine concentrations were compared for GDM vs control maternal, umbilical arterial and venous samples. Correlations were explored between biochemical results, maternal and neonatal demographics. Results Compared with age-and weight-matched control participants, GDM women had significantly lower concentrations of 25(OH)D (77Á3 AE 24Á3 vs 93Á2 AE 19Á2 nm/l; P = 0Á009); adiponectin (17Á5 AE 11Á8 vs 34Á1 AE 20Á3 μg/ml, P < 0Á001); resistin (25Á4 AE 9Á1 vs 31Á9 AE 12Á1 ng/ml, P = 0Á045); and plasminogen activator inhibitor-1 (PAI-1) 13Á9 AE 10Á0 vs 21Á0 AE 12Á6 ng/ml, P = 0Á038), while delivering 1 week earlier (38Á2 AE 1Á2 vs 39Á5 AE 0Á9 weeks, P < 0Á001). GDM maternal 25(OH)D concentrations positively correlated with PAI-1, IL-8 and TNF-a concentrations. Umbilical 25(OH)D concentrations were not significantly different in GDM vs control offspring, whereas adiponectin, resistin and PAI-1 concentrations were significantly lower in GDM offspring. Conclusions GDM women had lower 25(OH)D concentrations than controls, while neonatal umbilical concentrations of 25 (OH)D did not differ. GDM maternal and GDM offspring had lower adiponectin, resistin and PAI-1 concentrations compared with controls. Results suggest that both GDM women and their offspring demonstrate abnormal adipocytokine patterns.

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“…Besides the positive correlation between plasma resistin level and GDM [71], there are studies demonstrating its either decreased [73] or unchanged [74] concentration in diabetic pregnant women. A recent meta-analysis concerning the relationship of resistin with GDM revealed no difference in plasma resistin level between GDM subjects and control pregnant women [75]. However, these findings should be treated with caution due to considerable heterogeneity among analysed studies [75].…”

Section: Prace Poglądowementioning

confidence: 98%

“…A recent meta-analysis concerning the relationship of resistin with GDM revealed no difference in plasma resistin level between GDM subjects and control pregnant women [75]. However, these findings should be treated with caution due to considerable heterogeneity among analysed studies [75]. Thus, it is clear that further studies are required to understand the accurate pathophysiologic role of resistin in human diabetic pregnancy.…”

Section: Prace Poglądowementioning

confidence: 99%

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

Wójcik¹,

Chmielewska-Kassassir²,

Grzywnowicz³

et al. 2014

Endokrynologia Polska

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Gestational diabetes mellitus (GDM) is defined as a glucose intolerance of varying severity with onset or first recognition during pregnancy. The prevalence of GDM is growing rapidly worldwide, resulting in numerous and serious complications for both mother and foetus. Two major metabolic disorders, insulin resistance and β cells dysfunction, are currently linked to the pathogenesis of GDM, although the cellular mechanisms involved in the development of GDM are not yet completely understood. Increasing evidence from clinical and experimental studies indicates that adipose tissue dysfunction, characterised by abnormal production of adipokines, is an essential factor linked to insulin resistance and GDM. To date, several adipose tissue-derived hormones have been identified, including leptin, adiponectin, resistin, visfatin, apelin, retinol-binding protein 4 (RBP-4), vaspin, and omentin. The relationship of leptin and adiponectin to insulin resistance in GDM is relatively well documented, but the molecular mechanisms by which these hormones affect insulin resistance are not yet fully known. The other aforementioned adipokines appear to be also important players in the pathophysiology of GDM, although their precise function in this complex process remains to be established. The aim of this article is to review the literature concerning the relationship between the above-mentioned adipokines and GDM, and to clarify their role in the pathophysiology of GDM. Key words: adipokines; adiponectin; gestational diabetes mellitus (GDM); leptin; omentin; RBP-4; resistin; vaspin; visfatin StreszczenieCukrzyca ciążowa (GDM) jest definiowana jako nietolerancja glukozy, która po raz pierwszy wystąpiła lub została wykryta w czasie ciąży. Zachorowalność na GDM szybko wzrasta na świecie, prowadząc do licznych i poważnych powikłań zarówno u matki, jak i płodu. Dwa główne zaburzenia metaboliczne, czyli oporność na insulinę i dysfunkcja komórek b, biorą udział w patogenezie GDM, jednak komórkowe mechanizmy prowadzące do jej rozwoju nie są jeszcze do końca poznane. Wyniki badań klinicznych i eksperymentalnych wskazują, że dysfunkcja tkanki tłuszczowej, charakteryzująca się nieprawidłową produkcją adipokin, jest istotnym czynnikiem związanym z GDM. Do tej pory zidentyfikowano kilka hormonów wytwarzanych przez tkankę tłuszczową, w tym leptynę, adiponektynę, rezystynę, wisfatynę, apelinę, białko wiążące retinol 4 (RBP-4), waspinę i omentynę. Spośród nich stosunkowo dobrze udokumentowany jest związek leptyny i adiponektyny z insulinoopornością w GDM, ale molekularne mechanizmy działania obydwu hormonów w tym procesie nie są jeszcze całkowicie wyjaśnione. Pozostałe wyżej wymienione adipokiny wydają się być również istotnymi czynnikami w patofizjologii GDM, chociaż ich dokładna funkcja w tym kompleksowym procesie pozostaje niejasna. Celem niniejszego artykułu był przegląd istniejącej literatury dotyczącej związku między wyżej wymienionymi adipokinami i GDM oraz wyjaśnienie ich roli w patofizjologii GDM. (Endokrynol Pol 2014; 65 (2): 1...

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Resistin concentration and gestational diabetes: a systematic review of the literature

Cited by 35 publications

References 36 publications

Effects of the Use of Assisted Reproductive Technologies and an Obesogenic Environment on Resistance Artery Function and Diabetes Biomarkers in Mice Offspring

Effects of the Use of Assisted Reproductive Technologies and an Obesogenic Environment on Resistance Artery Function and Diabetes Biomarkers in Mice Offspring

Maternal, umbilical arterial and umbilical venous 25‐hydroxyvitamin D and adipocytokine concentrations in pregnancies with and without gestational diabetes

Związek hormonów pochodzących z tkanki tłuszczowej z cukrzycą ciążową (GDM)

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