Resistin regulates reproductive hormone secretion from the ovine adenohypophysis depending on season

Biernat, Weronika; Kirsz, Katarzyna; Szczęsna, M.; Zieba, D

doi:10.1016/j.domaniend.2018.07.001

Cited by 11 publications

(25 citation statements)

References 22 publications

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“…Data from many studies in ruminants proved that leptin regulates reproductive processes depending on metabolic and photoperiodic conditions, and our experiments demonstrated that RSTN is engaged in mechanisms of those regulations as well [ 11 , 31 ]. Seasonal breeding is a remarkable adaptive feature that allows sheep to optimize their survival and reproductive success.…”

Section: Discussionmentioning

confidence: 60%

“…Food restriction increased ( p < 0.001) concentrations of circulating GH. The secretory profiles of LH and GH were characterized using previously reported pulse analysis techniques [ 11 ]. Pulse amplitudes of LH were higher ( p < 0.05) in fat ewes than in lean ewes, with no changes in pulse frequency; however, GH pulse amplitude and frequency did not significantly differ between the lean and fat groups of ewes.…”

Section: Resultsmentioning

confidence: 99%

“…Seasonal breeding is a remarkable adaptive feature that allows sheep to optimize their survival and reproductive success. Our group indicated for the first time that RSTN is involved in the regulation of pituitary hormone secretions and that those effects were differentially mediated during the LD and short-day seasons [ 11 ]. RSTN regulated the release of reproductive hormones from the AP in a dose- and day length-dependent manner [ 11 , 35 ].…”

Section: Discussionmentioning

confidence: 99%

“…Earlier, in 2018, our team presented that in seasonally breeding ovariectomized ewes with estradiol replacement action of RSTN on the level of AP appeared to be firmly dose- and photoperiod-dependent. RSTN modulated reproductive hormone secretions: luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) [ 11 ]. Thus, it has been suggested that RSTN is involved in the regulation of seasonal reproduction in sheep [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

“…RSTN modulated reproductive hormone secretions: luteinizing hormone (LH), follicle stimulating hormone (FSH) and prolactin (PRL) [ 11 ]. Thus, it has been suggested that RSTN is involved in the regulation of seasonal reproduction in sheep [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

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Changes in Expression of the Genes for the Leptin Signaling in Hypothalamic-Pituitary Selected Areas and Endocrine Responses to Long-Term Manipulation in Body Weight and Resistin in Ewes

Zieba

Biernat

Szczęsna

et al. 2020

IJMS

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Both long-term undernutrition and overnutrition disturb metabolic balance, which is mediated partially by the action of two adipokines, leptin and resistin (RSTN). In this study, we manipulated the diet of ewes to produce either a thin (lean) or fat (fat) body condition and investigated how RSTN affects endocrine and metabolic status under different leptin concentrations. Twenty ewes were distributed into four groups (n = 5): the lean and fat groups were administered with saline (Lean and Fat), while the Lean-R (Lean-Resistin treated) and Fat-R (Fat-Resistin treated) groups received recombinant bovine resistin. Plasma was assayed for LH, FSH, PRL, RSTN, leptin, GH, glucose, insulin, total cholesterol, nonesterified fatty acid (NEFA), high-density lipoprotein (HDL)-cholesterol, low-density lipoprotein (LDL)-cholesterol and triglycerides. Expression levels of a suppressor of cytokine signaling (SOCS-3) and the long form of the leptin receptor (LRb) were determined in selected brain regions, such as the anterior pituitary, hypothalamic arcuate nucleus, preoptic area and ventro- and dorsomedial nuclei. The results indicate long-term alterations in body weight affect RSTN-mediated effects on metabolic and reproductive hormones concentrations and the expression of leptin signaling components: LRb and SOCS-3. This may be an adaptive mechanism to long-term changes in adiposity during the state of long-day leptin resistance.

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Section: Discussionmentioning

confidence: 60%

Section: Resultsmentioning

confidence: 99%