Resolution and Mass Range Performance in Distance-of-Flight Mass Spectrometry with a Multichannel Focal-Plane Camera Detector

Graham, Alexander W. G.; Ray, Steven J.; Enke, Christie G.; Felton, Jeremy; Carado, Anthony J.; Barinaga, Charles J.; Koppenaal, David W.; Hieftje, Gary M.

doi:10.1021/ac201876y

Cited by 18 publications

(31 citation statements)

References 27 publications

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“…The concept of space-focusing in CEA-TOFMS is well established as is the use of a reflectron to mirror the space focus and to partially compensate for ionenergy disparities [23]. The concept of energy-focused CMA was introduced in 2007 [24] and has been applied to both distance-of-flight MS (DOFMS) [25][26][27][28][29][30][31] and TOFMS [22,32,33].…”

Section: Introductionmentioning

confidence: 99%

Inductively Coupled Plasma Zoom–Time-of-Flight Mass Spectrometry

Dennis

Ray

Enke³

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. A zoom-time-of-flight mass spectrometer has been coupled to an inductively coupled plasma (ICP) ionization source. Zoom-time-of-flight mass spectrometry (zoom-TOFMS) combines two complementary types of velocity-based mass separation. Specifically, zoom-TOFMS alternates between conventional, constantenergy acceleration (CEA) TOFMS and energy-focused, constant-momentum acceleration (CMA) (zoom) TOFMS. The CMA mode provides a mass-resolution enhancement of 1.5-1.7× over CEA-TOFMS in the current, 35-cm ICP-zoom-TOFMS instrument geometry. The maximum resolving power (full-width at half-maximum) for the ICP-zoom-TOFMS instrument is 1200 for CEA-TOFMS and 1900 for CMA-TOFMS. The CMA mode yields detection limits of between 0.02 and 0.8 ppt, depending upon the repetition rate and integration time-compared with single ppt detection limits for CEA-TOFMS. Isotope-ratio precision is shot-noise limited at approximately 0.2% relative-standard deviation (RSD) for both CEA-and CMA-TOFMS at a 10 kHz repetition rate and an integration time of 3-5 min. When the repetition rate is increased to 43.5 kHz for CMA, the shot-noise limited, zoom-mode isotope-ratio precision is improved to 0.09% RSD for the same integration time.

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Section: Introductionmentioning

confidence: 99%

Inductively Coupled Plasma Zoom–Time-of-Flight Mass Spectrometry

Dennis

Ray

Enke³

et al. 2015

J. Am. Soc. Mass Spectrom.

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“…ince the development of distance-of-flight mass spectrometry (DOFMS) theory by Enke and Dobson [1], several papers have shown its experimental viability [2][3][4][5][6][7][8][9]. Conceptually, mass-to-charge (m/z) separation in DOFMS is similar to that in time-of-flight mass spectrometry (TOFMS), while the ion detection process resembles that of spatially dispersive, sectorfield mass spectrometry (SFMS).…”

mentioning

confidence: 99%

“…Earlier work on DOFMS was conducted with two alternative ion detectors employed in the same instrument [9]: a microchannel plate-phosphor screen (MCP/phosphor) combination [2,[5][6][7] and a multichannel focal plane camera (FPC) [3,4]. The MCP/phosphor assembly has a 4.0-cm active length [2] and, in combination with a CCD camera, provides a linear dynamic range (LDR) of five orders of magnitude [5] and a full-width at half-maximum mass resolving power (RP FWHM ) of approximately 500 [6].…”

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confidence: 99%

“…The FPC can detect the true DOFMS massspectral peak width [3], has no mass bias [3], and can provide high isotope-ratio precision [11]. Several generations of the FPC have been developed [11][12][13][14][15][16], but the FPC detection system employed for DOFMS offers only 0.64 cm of active length (512, 8.5-μm wide detection pixels at a 12.5-μm pitch) [3,7,13]. This FPC provides a RP FWHM of approximately 1000 for DOFMS [3].…”

mentioning

confidence: 99%

“…Several generations of the FPC have been developed [11][12][13][14][15][16], but the FPC detection system employed for DOFMS offers only 0.64 cm of active length (512, 8.5-μm wide detection pixels at a 12.5-μm pitch) [3,7,13]. This FPC provides a RP FWHM of approximately 1000 for DOFMS [3]. Although the FPC provides superior mass resolution and a broader LDR (at least nine orders of magnitude when coupled to a Mattauch-Herzog mass spectrograph [12]), the MCP/phosphor screen enables a larger portion of the mass spectrum to be evaluated at once.…”

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confidence: 99%

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Distance-of-Flight Mass Spectrometry with IonCCD Detection and an Inductively Coupled Plasma Source

Dennis

Ray

Enke³

et al. 2015

J. Am. Soc. Mass Spectrom.

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Abstract. Distance-of-flight mass spectrometry (DOFMS) is demonstrated for the first time with a commercially available ion detector-the IonCCD camera. Because DOFMS is a velocity-based MS technique that provides spatially dispersive, simultaneous mass spectrometry, a position-sensitive ion detector is needed for massspectral collection. The IonCCD camera is a 5.1-cm long, 1-D array that is capable of simultaneous, multichannel ion detection along a focal plane, which makes it an attractive option for DOFMS. In the current study, the IonCCD camera is evaluated for DOFMS with an inductively coupled plasma (ICP) ionization source over a relatively short field-free mass-separation distance of 25.3-30.4 cm. The combination of ICP-DOFMS and the IonCCD detector results in a mass-spectral resolving power (FWHM) of approximately 900 and isotope-ratio precision equivalent to or slightly better than current ICP-TOFMS systems. The measured isotope-ratio precision in % relative standard deviation (%RSD) was ≥0.008%RSD for nonconsecutive isotopes at 10-ppm concentration (near the ion-signal saturation point) and ≥0.02%RSD for all isotopes at 1-ppm. Results of DOFMS with the IonCCD camera are also compared with those of two previously characterized detection setups.

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In pursuit of resolution in time‐of‐flight mass spectrometry: A historical perspective

Radionova

Filippov

Derrick

2015

Mass Spectrometry Reviews

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Time-of-flight mass spectrometry is reviewed from its inception in the 1940s to the present day. The review is concerned with fundamentals of time-of-flight analyzers and of ion sources to the extent that sources influence analyzers. The patent literature has been covered, and efforts made to bring to light less well-known papers and studies © 2015 Wiley Periodicals, Inc. Mass Spec Rev. 35:738-757, 2016.

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Resolution and Mass Range Performance in Distance-of-Flight Mass Spectrometry with a Multichannel Focal-Plane Camera Detector

Cited by 18 publications

References 27 publications

Inductively Coupled Plasma Zoom–Time-of-Flight Mass Spectrometry

Inductively Coupled Plasma Zoom–Time-of-Flight Mass Spectrometry

Distance-of-Flight Mass Spectrometry with IonCCD Detection and an Inductively Coupled Plasma Source

In pursuit of resolution in time‐of‐flight mass spectrometry: A historical perspective

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