Resolution of 1,3-dioxolane derivatives using the lipase from an Acinetobacter junii SY-01

How the mode of Candida antarctica lipase B immobilization affects the continuous-flow kinetic resolution of racemic amines at various temperatures

“…In a wide range of enzymatic reactions decreasing selectivity with increasing temperature was observed [16][17][18][19][20][21][22][23][24][25] and there are only a few examples in which higher temperature resulted in higher selectivity [26,27]. Occasionally, temperature had no effect on enantioselectivity [28], whereas in other cases a maximum of enantioselectivity at a certain temperature was found [29].…”

Additives Enhancing the Catalytic Properties of Lipase from Burkholderia cepacia Immobilized on Mixed-Function-Grafted Mesoporous Silica Gel

“…Effect of the temperature on selectivity is one of the major concerns in enzymatic transformations. In most of the cases – usually investigated in batch mode – stereoselectivity of enzyme catalyzed reactions was decreased with increasing temperature [52,53,54,55,56,57,58,59,60,61,62]. A few examples were found where enantiomer selectivity of enzyme-catalyzed kinetic resolutions (KRs) increased with increasing temperature [63,64] or had a maximum [32,65,66].…”

Lipase-Catalyzed Kinetic Resolution of 1-(2-Hydroxycyclohexyl)Indoles in Batch and Continuous-Flow Systems

“…In enzymecatalysed reactions, increasing temperature generally decreases selectivity. [52][53][54][55][56][57][58][59][60][61][62] In a few studies, however, enhanced selectivity with increasing temperature, 63,64 or a maximum of enantioselectivity at a certain temperature, 38,65 or even indifference to temperature was found. 66 In most of the quoted examples, the enzyme-catalysed reactions were carried out in batch mode (in stirred or shaken flasks) and only a few studies on the temperature effects on lipase-catalysed KRs were performed in continuous-flow mode so far.…”