Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic

Noguera, T.; Wotring, Robert; Melville, C; Hargraves, Kara; Kumm, Jochen; Morton, John

doi:10.3748/wjg.v20.i34.12301

Cited by 16 publications

(12 citation statements)

References 13 publications

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“…A single study of polyphenol-based prebiotic has been described in the treatment of acute diarrhea in children and adults seeking treatment at community health centers in Managua, Nicaragua ( 92 ). No diarrhea case defi nition (e.g., frequency or duration) for inclusion was reported; however, exclusion critieria included those with high fever, vomiting, severe dehydration, and bloody stools.…”

Section: Recommendationmentioning

confidence: 99%

ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults

Riddle

DuPont

Connor

2016

American Journal of Gastroenterology

331

250

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Acute diarrheal infections are a common health problem globally and among both individuals in the United States and traveling to developing world countries. Multiple modalities including antibiotic and non-antibiotic therapies have been used to address these common infections. Information on treatment, prevention, diagnostics, and the consequences of acute diarrhea infection has emerged and helps to inform clinical management. In this ACG Clinical Guideline, the authors present an evidence-based approach to diagnosis, prevention, and treatment of acute diarrhea infection in both US-based and travel settings. Am J Gastroenterol 2016; 111:602-622; doi: 10.1038/ajg.2016 A follow-up survey where 3,568 respondents (median age 51) were asked at random about illness in the previous 7 days or previous month found that recall bias had an important eff ect on estimates of acute gastrointestinal illness ( 10 ). Using a 7-day exposure window, the estimated incidence of acute diarrhea was 1.6 episodes per person-year, compared with 0.9 episodes per person-year if asked about illness within the preceding month. Other population-based studies from Canada and western European countries using varied methodologies estimate annual incidence between 0.1 to 3.5 episodes per person-year ( 11 18. Antibiotic chemoprophylaxis has moderate to good effectiveness and may be considered in high-risk groups for short-term use. (Strong recommendation, high level of evidence) TD, traveler's diarrhea.

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Section: Recommendationmentioning

confidence: 99%

ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults

Riddle

DuPont

Connor

2016

American Journal of Gastroenterology

331

250

View full text Add to dashboard Cite

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“…Short-term interventions have also been conducted, though with rather more questionable results, in part as inflammation processes are less likely to be altered drastically during short-term trials. However, children with gastroenterological discomfort receiving a novel polyphenol based prebiotic (2 ounces of Preliva (Goodgut INC, USA), rich in Japanese honeysuckle, grape, and pomegranate, among others) within a single dose in a placebo controlled trial experienced significantly less stomach pain and discomfort compared to the placebo group, though no bacteria cultures were measured and no dosing was reported [ 118 ]. More such studies, with preferably mid-long-term administration of polyphenols, are much desired.…”

Section: Insights From Human Trialsmentioning

confidence: 99%

Bioactivity of Polyphenols: Preventive and Adjuvant Strategies toward Reducing Inflammatory Bowel Diseases—Promises, Perspectives, and Pitfalls

Kaulmann

Bohn

2016

Oxidative Medicine and Cellular Longevity

130

105

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Inflammatory bowel diseases (IBDs) are characterized by autoimmune and inflammation-related complications of the large intestine (ulcerative colitis) and additional parts of the digestive tract (Crohn's disease). Complications include pain, diarrhoea, chronic inflammation, and cancer. IBD prevalence has increased during the past decades, especially in Westernized countries, being as high as 1%. As prognosis is poor and medication often ineffective or causing side effects, additional preventive/adjuvant strategies are sought. A possible approach is via diets rich in protective constituents. Polyphenols, the most abundant phytochemicals, have been associated with anti-inflammatory, antioxidant, immunomodulatory, and apoptotic properties. Locally reducing oxidative stress, they can further act on cellular targets, altering gene expression related to inflammation, including NF-κB, Nrf-2, Jak/STAT, and MAPKs, suppressing downstream cytokine formation (e.g., IL-8, IL-1β, and TNF-α), and boosting the bodies' own antioxidant status (HO-1, SOD, and GPx). Moreover, they may promote, as prebiotics, healthy microbiota (e.g., Bifidobacteria, Akkermansia), short-chain fatty acid formation, and reduced gut permeability/improved tight junction stability. However, potential adverse effects such as acting as prooxidants, or perturbations of efflux transporters and phase I/II metabolizing enzymes, with increased uptake of undesired xenobiotics, should also be considered. In this review, we summarize current knowledge around preventive and arbitrary actions of polyphenols targeting IBD.

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“…Besides their beneficial role in modulating short-chain fatty acids (SCFAs) or even intestinal IgA secretion ( 41 ), only a few interventional studies have been conducted to investigate the role of prebiotics against RV infection. However, because of their importance in early life, such as through human milk oligosaccharides or specific mixtures of short-chain galactooligosaccharides (scGOSs) and long-chain fructooligosaccharides (lcFOSs), which are widely used in infant formulas, prebiotics have been studied most in both preclinical ( 42 , 43 ) and clinical ( 44 , 45 ) studies involving RV infection.…”

Section: Introductionmentioning

confidence: 99%

Preventive Effect of a Synbiotic Combination of Galacto- and Fructooligosaccharides Mixture With Bifidobacterium breve M-16V in a Model of Multiple Rotavirus Infections

et al. 2018

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Rotavirus (RV) causes morbidity and mortality among infants worldwide, and there is evidence that probiotics and prebiotics can have a positive influence against infective processes such as that due to RV. The aim of this study was to evidence a preventive role of one prebiotic mixture (of short-chain galactooligosaccharide/long-chain fructooligosaccharide), the probiotic Bifidobacterium breve M-16V and the combination of the prebiotic and the probiotic, as a synbiotic, in a suckling rat double-RV infection model. Hyperimmune bovine colostrum was used as protection control. The first infection was induced with RV SA11 and the second one with EDIM. Clinical variables and immune response were evaluated after both infections. Dietary interventions ameliorated clinical symptoms after the first infection. The prebiotic and the synbiotic significantly reduced viral shedding after the first infection, but all the interventions showed higher viral load than in the RV group after the second infection. All interventions modulated ex vivo antibody and cytokine production, gut wash cytokine levels and small intestine gene expression after both infections. In conclusion, a daily supplement of the products tested in this preclinical model is highly effective in preventing RV-induced diarrhea but allowing the boost of the early immune response for a future immune response against reinfection, suggesting that these components may be potential agents for modulating RV infection in infants.

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Resolution of acute gastroenteritis symptoms in children and adults treated with a novel polyphenol-based prebiotic

Abstract: In this double-blind, randomized clinical study, subjects with acute gastroenteritis receiving Aliva prebiotic showed significant and sustained improvement of multiple symptoms vs those receiving placebo.

Cited by 16 publications

References 13 publications

ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults

ACG Clinical Guideline: Diagnosis, Treatment, and Prevention of Acute Diarrheal Infections in Adults

Bioactivity of Polyphenols: Preventive and Adjuvant Strategies toward Reducing Inflammatory Bowel Diseases—Promises, Perspectives, and Pitfalls

Preventive Effect of a Synbiotic Combination of Galacto- and Fructooligosaccharides Mixture With Bifidobacterium breve M-16V in a Model of Multiple Rotavirus Infections

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