Resolution of cerebral vasospasm with trapidil; an animal model

The Impact of Subarachnoid Hemorrhage on Regional Cerebral Blood Flow and Large-vessel Diameter in the Canine Model of Chronic Vasospasm

“…During the past decades, human studies and animal experiments primarily focused on the pathophysiology of cerebral VS or were directed to investigate new substances effective in relieving VS. [3][4][5][6][7] In animal models, angiography of the basilar artery was usually performed and arterial diameter served as the main parameter on which to judge drug activity. [8][9][10] Quantitative measurements of regional cerebral blood flow (rCBF), however, were usually not integrated in the experimental setting. [11][12][13][14] A marked discrepancy may exist between VS of the cerebral arteries detected either by angiography or by transcranial Doppler (TCD) and the neurologic condition of the patient.…”