Resolution of Hyperlipidemia after Laparoscopic Roux-en-Y Gastric Bypass

Nguyen, Ninh T.; Varela, Esteban; Sabio, Allen; Tran, Cam-Ly; Stamos, Michael J.; Wilson, Samuel E.

doi:10.1016/j.jamcollsurg.2006.03.019

Cited by 126 publications

(62 citation statements)

References 15 publications

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“…Diabetes mellitus was completely resolved in the majority of the patients, finding supported by other reports, which also proposed mechanisms that this can be achieved [11,12] . Hypercholesterolemia was resolved in the majority of patients and hypertriglyceridemia in all patients, results similar to those described for malabsorptive procedures [13,14] . Regarding metabolic complications the most significant were vitamin B 12 and iron deficiency.…”

Section: Discussionsupporting

confidence: 82%

Prospective evaluation of laparoscopic Roux en Y gastric bypass in patients with clinically severe obesity

Vagenas¹,

Panagiotopoulos²,

Kehagias³

et al. 2008

WJG

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AIM:To evaluate and present our experience with laparoscopic Roux en Y gastric bypass (RYGB) in a selected patient population. METHODS: A cohort of 130 patients with a body mass index (BMI) between 35 and 50 kg/m 2 were evaluated in relation to postoperative morbidity, weight loss and resolution of co-morbidities for a period of 4 years following laparoscopic RYGB. RESULTS: Early morbidity was 10.0%, including 1 patient with peritonitis who was admitted to Intensive Care Unit (ICU) and 1 conversion to open RYGB early in the series. There was no early or late mortality. Maximum weight loss was achieved at 12 mo postoperatively, with mean BMI 30 kg/m 2 , mean percentage of excess weight loss (EWL%) 66.4% and mean percentage of initial weight loss (IWL%) 34.3% throughout the follow-up period. The majority of preexisting comorbidities were resolved after weight loss and no major metabolic disturbances or nutritional deficiencies were observed. CONCLUSION: Laparoscopic RYGB appears to be a safe and effective procedure for patients with BMI 35-50 kg/m 2 with results that are comparable to previously published data mostly from the USA but from Europe as well.

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Section: Discussionsupporting

confidence: 82%

Prospective evaluation of laparoscopic Roux en Y gastric bypass in patients with clinically severe obesity

Vagenas¹,

Panagiotopoulos²,

Kehagias³

et al. 2008

WJG

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“…The anthropometric characteristics and parameters related to lipid and glucose metabolism measured in decreased overall mortality ( 5 ) and often resulted in signifi cant improvements in lipid parameters and CVD risk (6)(7)(8)(9)(10). Increased circulating adiponectin concentrations, improvements of insulin sensitivity, decreased heart rate and hypertension, and other comorbidities of severe obesity have also been shown to accompany substantial weight loss after RYGBP surgery (11)(12)(13)(14)(15)(16).…”

Section: Resultsmentioning

confidence: 99%

Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

Asztalos

Swarbrick

Schaefer

et al. 2010

The Journal of Lipid Research

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Journal of Lipid ResearchCardiovascular disease (CVD) is the leading cause of death and disability in the United States. Obesity is associated with hypertension, diabetes, elevated triglyceride (TG) levels, and decreased HDL-cholesterol (HDL-C) levels, all acknowledged as independent CVD risk factors by the AHA ( 1 ). Obesity, defi ned by body mass index (BMI) у 30 kg/m 2 , often coexists with the metabolic syndrome, which is associated with increased CVD risk. High BMI has been associated with increased risk for the development of coronary, cerebral, and peripheral vascular disease; however, due to the coexistence of multiple risk factors, the quantitative assessment of CVD risk exclusively associated with obesity is complicated.Bariatric surgery is an effective intervention to achieve long-term marked weight reduction in patients with morbid obesity ( 2, 3 ). It has recently been published that calculated 10 year CVD risk (based on the Framingham equation) in morbidly obese subjects decreased by 1.3% 12 months after laparoscopic Roux-en-Y gastric bypass (RYGBP) surgery ( 4 ) and that substantial weight loss, following RYGBP surgery, Abstract Plasma lipoproteins and glucose homeostasis were evaluated after marked weight loss before and over 12 months following Roux-en-Y gastric-bypass (RYGBP) surgery in 19 morbidly obese women. Standard lipids, remnant-lipoprotein cholesterol (RLP-C); HDL-triglyceride (TG); apolipoproteins (apo) A-I, A-II, E, and A-I-containing HDL subpopulations; lecithin-cholesterol acyltransferase (LCAT)and cholesteryl ester transfer protein ( CETP) mass and activity; plasma glucose and insulin levels were measured before and at 1, 3, 6, and 12 months after GBP surgery. Baseline concentrations of TG, RLP-C, glucose, and insulin were signifi cantly higher in obese than in normal-weight, age-matched women, whereas HDL cholesterol (HDL-C), apoA-I, apoA-II, ␣ -1 and ␣ -2 levels were signifi cantly lower. Over 1 year, signifi cant decreases of body mass index, glucose, insulin, TG, RLP-C, HDL-TG, and pre ␤ -1 levels were observed with signifi cant increases of HDL-C and ␣ -1 levels (all P < 0.05). Changes of fat mass were correlated with those of LDL cholesterol ( P = 0.018) and LCAT mass ( P = 0.011), but not with CETP mass ( P = 0.265). Changes of fasting plasma glucose concentrations were inversely correlated with those of CETP mass ( P = 0.005) and ␣ -1 level ( P = 0.004). Changes of fasting plasma insulin concentrations were positively correlated with those of LCAT mass ( P = 0.043) and inversely with changes of ␣ -1 ( P = 0.03) and ␣ -2 ( P = 0.05) concentrations. These results demonstrate benefi cial changes in HDL remodeling following substantial weight loss induced by RYGBP surgery and that these changes are associated with improvement of glucose homeostasis in these patients. -Asztalos, B.

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“…So now a day's bariatric surgeries are increasingly focused on lipid profile in the drive to potentially reduce cardiovascular related disease. 15,16 The aim of the study is monitor the changes of lipid profile in selected parameters to 9 month postoperatively.…”

Section: Introductionmentioning

confidence: 99%

Effect of laparoscopic sleeve gastrectomy on lipid profile of obese patients in complete nine month follow up

et al. 2016

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Resolution of Hyperlipidemia after Laparoscopic Roux-en-Y Gastric Bypass

Cited by 126 publications

References 15 publications

Prospective evaluation of laparoscopic Roux en Y gastric bypass in patients with clinically severe obesity

Prospective evaluation of laparoscopic Roux en Y gastric bypass in patients with clinically severe obesity

Effects of weight loss, induced by gastric bypass surgery, on HDL remodeling in obese women

Effect of laparoscopic sleeve gastrectomy on lipid profile of obese patients in complete nine month follow up

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