Resolution of optical isomers of 4-amino-p-chlorobutyric acid lactam by co-crystallization

Organic–inorganic ionic co-crystals: a new class of multipurpose compounds

“…The use of co-crystallization as an instrument to resolve enantiomers from a racemate has been successfully employed in a number of cases. 47,48 The basic idea is that an enantiopure co-former ought to interact selectively and differently with the enantiomers, leading to the formation of different "supramolecular diastereomers" with the enantiomers of opposite chirality. Co-crystals of enantiopure (homochiral) and achiral amino acid zwitterions with Li + and Cl − or NO 3 − counterions have also been reported.…”

Ternary and quaternary phase diagrams: key tools for chiral resolution through solution cocrystallization

“…Opposite to salts, cocrystals frequently show enantiospecific behavior, with only one of two enantiomers forming a cocrystal with a chiral coformer. 7,[14][15][16][17][18][19][20] Using such an enantiospecific system, we were able to develop a new resolution tool based on enantiospecific cocrystallization in solution. 21 The goal of this article is to describe the thermodynamics behind this system, introducing quaternary phase diagrams.…”

Chemistry and Insulin-Mimetic Properties of Bis(acetylacetonate)oxovanadium(IV) and Derivatives1

“…Previously, many spectroscopic methods were employed to determine the coordination number, 22,23,[29][30][31][32] the geometry of the complex, and whether the incoming ligand was trans or cis to the oxo group. [33][34][35][36] Although the literature is not in complete agreement, 37 the consensus strongly favors 35,36,38,39 that the incoming ligand coordinates trans to the oxo group in the case of neutral oxygen donors (see Figure 1 for illustration of trans-VO(acac) 2 ‚H 2 O and cis-VO(acac) 2 ‚H 2 O adducts). Despite many studies exploring the geometry of the VO(acac) 2 L adducts, no information currently is available on the chemistry of the adduct complex or its fivecoordinate parent in aqueous solution.…”