Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala

Etkin, Amit; Egner, Tobias; Peraza, Daniel M.; Kandel, Eric R.; Hirsch, Joy

doi:10.1016/j.neuron.2006.12.003

Cited by 60 publications

(76 citation statements)

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“…Emotional conflict control stems from cognitive control, which refers to the ability to select task-relevant emotional information and ignore task-irrelevant emotional distractors (Etkin et al 2006). In the daily life, many emotionally salient stimuli around us will interfere with our ongoing behavior.…”

Section: Introductionmentioning

confidence: 99%

“…The face-word Stroop task was widely used to measure emotional conflict in both psychological and clinical study (Etkin et al 2006;Etkin and Schatzberg 2011;Chechko et al 2013;Xue et al 2015). During this paradigm, participants need to judge facial expression of target face while ignoring the meaning of superimposed words.…”

Section: Introductionmentioning

confidence: 99%

“…During this paradigm, participants need to judge facial expression of target face while ignoring the meaning of superimposed words. Many previous fMRI studies investigated neural activity during the face-word task and identified some important brain regions during this task (Etkin et al 2006;Egner et al 2008;Chechko et al 2009Chechko et al , 2012. For example, Etkin et al (2006) found that task activation in amygdala (AMY) and dorsolateral prefrontal cortex (dlPFC) reflected the amount of emotional conflict.…”

Section: Introductionmentioning

confidence: 99%

“…Many previous fMRI studies investigated neural activity during the face-word task and identified some important brain regions during this task (Etkin et al 2006;Egner et al 2008;Chechko et al 2009Chechko et al , 2012. For example, Etkin et al (2006) found that task activation in amygdala (AMY) and dorsolateral prefrontal cortex (dlPFC) reflected the amount of emotional conflict. Egner et al (2008) found that there were two dissociable neural circuits for resolving emotional conflict or nonemotional conflict and that AMY and rostral anterior cingulate (rACC) were sensitive to emotional conflict.…”

Section: Introductionmentioning

confidence: 99%

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Amplitude of low-frequency oscillations associated with emotional conflict control

et al. 2016

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Previous fMRI studies related to emotional conflict focused on task activation during the specific experimental paradigm. Yet, the underlying spontaneous neural activity was largely unknown. Here, this was the first study using resting-state fMRI to explore the spontaneous neural activity related to emotional conflict. We used the whole-brain analysis to investigate the association between emotional conflict and amplitude of low-frequency fluctuations (ALFF) in a large sample. We found that the emotional conflict effect was negatively correlated with ALFF in the right AMY. These findings implied that AMY was the key region which plays a crucial role in emotional conflict.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Amplitude of low-frequency oscillations associated with emotional conflict control

et al. 2016

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“…Although there were hemispheric differences in these findings -left ACC and left UF in contrast to the right amygdala -these three structures nonetheless comprise a frontolimbic network that is involved in regulating emotion and reward processing (Bush et al 2000;Botvinick et al, 2004;Etkin et al 2006;Petrides & Pandya, 2007;Ghashghaei et al, 2007;Wang et al, 2009). More specifically, the ACC and subgenual regions that are considered the vmPFC send projections to the amygdala through the UF.…”

Section: Bmimentioning

confidence: 99%

Structural and functional neural correlates of a mind-body connection.

Faul¹

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The human brain underlies the complex cognitive processes of the mind, however, this is dependent upon the physiological processes of the body in order to receive adequate energy, oxygen, and blood flow. Therefore, physical measurements such as body mass index (BMI) and indices of cognitive functioning, such as intelligence, may be related via common neural features. Current analyses assessed morphometric differences in cortical and subcortical grey matter regions, white matter structural integrity, and resting-state functional activation in order to determine what combinations of neural variables predict BMI and intelligence (Wechsler Abbreviated Scale of Intelligence; WASI) with the best degree of accuracy. Data for eighty-five subjects was obtained from the Nathan Kline Institute, in connection with the 1000 Functional Connectomes neuroimaging database. Behavioral results indicated a negative correlation between BMI and WASI scores. Neural analyses revealed that increased BMI predicted changes in a frontolimbic network comprised of the anterior cingulate cortex, amygdala, and uncinate fasciculus, as well as increased cortical surface area of the left fusiform gyrus. These results indicate a relationship of BMI with emotional decision-making and visual recognition processes. Whereas, increased WASI scores predicted increased thickness and volume of prefrontal and parietal cortices, which reflect brain regions involved in the fronto-parietal attentional network. As well, increased WASI scores also related to a functional network that included increased activation of the postcentral gyrus and posterior hippocampal complex, regions involved with attention and memory. Taken together, these results indicate that BMI and intelligence are behaviorally anticorrelated, yet mediated by separate neuroanatomical substrates that associate with a variety of cognitive functioning measures.

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Individual differences and developmental change in the ERN response: implications for models of ACC function

Segalowitz

Dywan

2008

Psychological Research

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The anterior cingulate cortex (ACC) has been associated with conditions precipitating an increase in effortful processing or increased attention, including the presence of conflicting information and the detection of errors. The error-related negativity (ERN), an electrocortical response, has been used as a marker for these conditions. The ERN amplitude however is subject to developmental change across the lifespan as well as being sensitive to individual differences in personality, affect, and autonomic responsivity. In this review, we examine the implications of such influences for a standard ACC model of conflict processing, and outline the need of any model of ACC function to include mechanisms that allow for the integration of neurovisceral and cognitive domains.

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Resolving Emotional Conflict: A Role for the Rostral Anterior Cingulate Cortex in Modulating Activity in the Amygdala

Cited by 60 publications

References 0 publications

Amplitude of low-frequency oscillations associated with emotional conflict control

Amplitude of low-frequency oscillations associated with emotional conflict control

Structural and functional neural correlates of a mind-body connection.

Individual differences and developmental change in the ERN response: implications for models of ACC function

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