Flexible photodetectors have emerged during the past few years for applications in healthcare, security, and environmental monitoring. Recently, 2D materials have started being implemented as functional layers in flexible photodetector due to their outstanding optoelectronic characteristics paired with high mechanical flexibility. In this work, the authors analyze the progress of 2D material‐based flexible photodetectors architectures, with a focus on graphene family, (Di)chalcogenides and van der Waals heterostructures. The optical and mechanical characteristics of 2D materials flexible photodetectors are systematically analyzed. Furthermore, the processing techniques compatible with flexible substrates and proof‐of‐concept sensors integrating 2D material flexible photodetectors are also reviewed. In the last section, the remaining challenges and future perspectives are discussed, envisioning to support future developments in the field.