Resorbable additively manufactured scaffold imparts dimensional stability to extraskeletally regenerated bone

Vaquette, Cédryck; Mitchell, J.; Fernandez-Medina, Tulio; Pt, Sudheesh Kumar; Ivanovski, Sašo

doi:10.1016/j.biomaterials.2021.120671

Cited by 49 publications

(47 citation statements)

References 61 publications

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“…It is important to augment the alveolar ridge for enabling the placement of dental implants and thus to restore both functionality and esthetic appearance [ 90 ]. Rider [ 90 ] and Vaquette [ 136 ] proposed that printed scaffolds showed potential in transferring to alveolar vertical bone augmentation ( Figure 5 ). Due to the high compressive strength of the printed structure, these scaffolds may be applicable for procedures involving simultaneous implant placement and ridge augmentation.…”

Section: Pcl-based Composite Scaffolds Utilized In Different Situationsmentioning

confidence: 99%

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The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering

et al. 2021

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Bone tissue engineering commonly encompasses the use of three-dimensional (3D) scaffolds to provide a suitable microenvironment for the propagation of cells to regenerate damaged tissues or organs. 3D printing technology has been extensively applied to allow direct 3D scaffolds manufacturing. Polycaprolactone (PCL) has been widely used in the fabrication of 3D scaffolds in the field of bone tissue engineering due to its advantages such as good biocompatibility, slow degradation rate, the less acidic breakdown products in comparison to other polyesters, and the potential for loadbearing applications. PCL can be blended with a variety of polymers and hydrogels to improve its properties or to introduce new PCL-based composites. This paper describes the PCL used in developing state of the art of scaffolds for bone tissue engineering. In this review, we provide an overview of the 3D printing techniques for the fabrication of PCL-based composite scaffolds and recent studies on applications in different clinical situations. For instance, PCL-based composite scaffolds were used as an implant surgical guide in dental treatment. Furthermore, future trend and potential clinical translations will be discussed.

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Section: Pcl-based Composite Scaffolds Utilized In Different Situationsmentioning

confidence: 99%

“…( A ) Description of the clinical problem following surgical re-entry in previously elevated bone, resulting in significant bone resorption. ( B ) Timeline of the experimental approach involving a two-staged strategy; bone formation following surgical re-entry and implant placement [ 136 ]. Copyright 2021 Elsevier.…”

Section: Figurementioning

confidence: 99%

The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering

et al. 2021

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“…FDM enables high production rate at a low cost, which has positive implications for FDM's ability to be used widely in the clinical setting. Additionally, FDM may be used in conjunction with other scaffold fabrication techniques such as electrospinning; preclinical research has shown potential of this combined approach for biphasic constructs employed in vertical bone augmentation (Sudheesh Kumar et al, 2018;Vaquette et al, 2021) and regeneration of the periodontal complex and supporting alveolar bone (Vaquette et al, 2012).…”

Section: Types Of Additive Manufacturingmentioning

confidence: 99%

Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects

Latimer

Maekawa

Yao

et al. 2021

Front. Bioeng. Biotechnol.

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Additive manufacturing (AM) is the automated production of three-dimensional (3D) structures through successive layer-by-layer deposition of materials directed by computer-aided-design (CAD) software. While current clinical procedures that aim to reconstruct hard and soft tissue defects resulting from periodontal disease, congenital or acquired pathology, and maxillofacial trauma often utilize mass-produced biomaterials created for a variety of surgical indications, AM represents a paradigm shift in manufacturing at the individual patient level. Computer-aided systems employ algorithms to design customized, image-based scaffolds with high external shape complexity and spatial patterning of internal architecture guided by topology optimization. 3D bioprinting and surface modification techniques further enhance scaffold functionalization and osteogenic potential through the incorporation of viable cells, bioactive molecules, biomimetic materials and vectors for transgene expression within the layered architecture. These computational design features enable fabrication of tissue engineering constructs with highly tailored mechanical, structural, and biochemical properties for bone. This review examines key properties of scaffold design, bioresorbable bone scaffolds produced by AM processes, and clinical applications of these regenerative technologies. AM is transforming the field of personalized dental medicine and has great potential to improve regenerative outcomes in patient care.

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“…These properties make these cells suitable candidates for therapeutic application (reviewed by Chalisserry et al in [ 33 ]) in neurological disorders, angiogenesis, dentin-pulp regeneration and periodontal regeneration. PDLSCs, GFs, DPSCs, SHED, and DFSCs have been demonstrated to promote multiple-tissue regeneration, both in vitro and in vivo [ 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. However, cell therapy has several challenges, including high cost, insufficient cell number, and associated regulatory barriers.…”

Section: The Source and Characteristics Of Periodontal (Dental Pulp) Cellsmentioning

confidence: 99%

Periodontal and Dental Pulp Cell-Derived Small Extracellular Vesicles: A Review of the Current Status

et al. 2021

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Extracellular vesicles (EVs) are membrane-bound lipid particles that are secreted by all cell types and function as cell-to-cell communicators through their cargos of protein, nucleic acid, lipids, and metabolites, which are derived from their parent cells. There is limited information on the isolation and the emerging therapeutic role of periodontal and dental pulp cell-derived small EVs (sEVs, <200 nm, or exosome). In this review, we discuss the biogenesis of three EV subtypes (sEVs, microvesicles and apoptotic bodies) and the emerging role of sEVs from periodontal ligament (stem) cells, gingival fibroblasts (or gingival mesenchymal stem cells) and dental pulp cells, and their therapeutic potential in vitro and in vivo. A review of the relevant methodology found that precipitation-based kits and ultracentrifugation are the two most common methods to isolate periodontal (dental pulp) cell sEVs. Periodontal (and pulp) cell sEVs range in size, from 40 nm to 2 μm, due to a lack of standardized isolation protocols. Nevertheless, our review found that these EVs possess anti-inflammatory, osteo/odontogenic, angiogenic and immunomodulatory functions in vitro and in vivo, via reported EV cargos of EV–miRNAs, EV–circRNAs, EV–mRNAs and EV–lncRNAs. This review highlights the considerable therapeutic potential of periodontal and dental pulp cell-derived sEVs in various regenerative applications.

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Resorbable additively manufactured scaffold imparts dimensional stability to extraskeletally regenerated bone

Cited by 49 publications

References 61 publications

The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering

The Application of Polycaprolactone in Three-Dimensional Printing Scaffolds for Bone Tissue Engineering

Regenerative Medicine Technologies to Treat Dental, Oral, and Craniofacial Defects

Periodontal and Dental Pulp Cell-Derived Small Extracellular Vesicles: A Review of the Current Status

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