Resorption of deproteinized bovine bone mineral in a porcine calvaria augmentation model

Abstract

The model represents a pathologic situation of excess resorption of DBBM and bone in an augmented area. The underlying cellular mechanisms remain to be uncovered.

Influence of Particle Size of Deproteinized Bovine Bone Mineral on New Bone Formation and Implant Stability after Simultaneous Sinus Floor Elevation: A Histomorphometric Study in Minipigs

“…An interesting finding was the pronounced resorption of DBBM in a few selected areas where fibrous tissue from the maxillary‐zygomatic suture was allowed to grow into the augmented volume (Figure A). A similar finding was reported in a recent study using a porcine calvarial model . From the present study it seems likely that DBBM particles hosted in an osseous environment may undergo only limited resorption whenever exposed to the marrow cavity, whereas particles captured in fibrous tissue early in the healing phase are at significant risk of complete degradation.…”

Single tooth implants in the esthetic zone following a two‐stage all flapless approach: A retrospective analysis

“…The peri‐implant bone loss measured in this study is consistent with values reported in literature . Histomorphometric analysis, evaluating the resorption of deproteinized bovine bone mineral (DBBM) in a porcine calvaria augmentation model, revealed that more than 50% of the augmented DBBM has been resorbed after 12 weeks . Nevertheless, extraction sockets augmented with a xenogeneic material reveal decreased loss of bone at the buccal plate than nonaugmented sites .…”

Long‐Term Stability of Contour Augmentation in the Esthetic Zone: Histologic and Histomorphometric Evaluation of 12 Human Biopsies 14 to 80 Months After Augmentation

“…The presence of MNGCs on the surface of DBBM particles has been documented in several other clinical as well as animal studies 20,21,30,31,33,40,42‐46 . Most often, TRAP staining has been used to determine whether these MNGCs could be classified as osteoclast‐like cells or other cells from the macrophage‐monocyte lineage.…”

“…There is increasing evidence that DBBM particles have a low substitution rate only when the particles are osseointegrated, since pronounced resorption has been observed when DBBM was embedded in fibrous tissue during early healing 44‐46 . This observation has clinical implications for contour augmentation.…”