Resorption of sintered synthetic hydroxyapatite by osteoclasts in vitro

Gomi, Kazuhiro; Lowenberg, B.; Shapiro, Gideon; Davies, John E.

doi:10.1016/0142-9612(93)90216-o

Cited by 135 publications

(94 citation statements)

References 4 publications

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“…Notwithstanding the better response to the Ca-P coated implants we have to mention that this differ ence in surface roughness can also be responsible for the lower amount of bone contact to the cpTi im plants. This suggestion is supported by the findings of Courtney et al (1995) and Gomi et al (1993). They demonstrated that the amount and distribution of mineralized bone matrix is influenced by the sub stratum surface roughness.…”

Section: Initial Interfacial Healing and Ca-p Coated Oral Implantssupporting

confidence: 63%

Initial interfacial healing events around calcium phosphate (Ca‐P) coated oral implants

Hulshoff

Jansen

1997

Clinical Oral Implants Res

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The bone response to different calcium phosphate (Ca‐P) coated and non‐coated titanium implants was evaluated in a goat animal model. Two types of Ca‐P coatings have been investigated: an experimental plasma‐spray bi‐layered Ca‐P coating (FA‐HA) and an amorphous RF magnetron sputter coating (Ca‐P‐a). Fifty‐four conical screw shaped implants were inserted in the lateral and medial femoral condyles of 18 Saanen goats. After implantation periods of 3, 12 and 24 days, the bone‐implant interface was evaluated histologically and histomorphometrically. Light microscopical evaluation revealed that bone formation on the Ca‐P coated implants proceeded faster. At 24 days higher percentages of bone contact were measured for both Ca‐P coated implants than for non‐coated implants. However, this difference was only significant for the FA‐HA coated implants. On basis of these findings. we concluded that Ca‐P coatings show improved bone response due to an initial difference in bone cell response.

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Section: Initial Interfacial Healing and Ca-p Coated Oral Implantssupporting

confidence: 63%

Initial interfacial healing events around calcium phosphate (Ca‐P) coated oral implants

Hulshoff

Jansen

1997

Clinical Oral Implants Res

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“…Osteoblasts cultured on porous HA bioceramics appeared to exhibit a higher adhesion, an enhanced differentiation and suppressed proliferation rates when compared to the non-porous controls [643,644]. Furthermore, formation of distinct resorption pits on HA [645] and β-TCP [634] surfaces in the presence of osteoclasts was observed. Moreover, a surface roughness of calcium orthophosphate bioceramics was reported to strongly influence the activation of mononuclear precursors to mature osteoclasts [645].…”

Section: Bioactivitymentioning

confidence: 84%

“…Furthermore, formation of distinct resorption pits on HA [645] and β-TCP [634] surfaces in the presence of osteoclasts was observed. Moreover, a surface roughness of calcium orthophosphate bioceramics was reported to strongly influence the activation of mononuclear precursors to mature osteoclasts [645].…”

Section: Bioactivitymentioning

confidence: 96%

Medical Application of Calcium Orthophosphate Bioceramics

Dorozhkin¹

2011

BIO

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In the late 1960's, a strong interest was raised in biomedical applications of ceramic materials (named bioceramics a little bit later). Bioceramics was initially used as reasonable alternatives to metals in order to increase their biocompatibility. However, within a short period, it has grown into a diverse class of biomaterials, presently including three essential types: relatively bioinert, bioactive (or surface reactive) and bioresorbable bioceramics. This review is limited to bioceramics prepared from calcium orthophosphates only, which belong to the categories of bioactive and bioresorbable compounds. There have been a number of important advances in this field during the past 30 -40 years. The research was shifted from an initial study on the develop-ment of bioinert bioceramics towards bioactive and bioresorbable bioceramics, and these different types of calcium orthophosphate bioceramics can be tuned through the structural and compositional control. At the turn of the millennium, a new concept of calcium orthophosphate bioceramics has been developed to promote a regeneration of bones. Current biomedical applications of calcium orthophosphate bioceramics include artificial replacements for hips, knees, teeth, tendons and ligaments, as well as repair for periodontal disease, maxillofacial reconstruction, augmenttation and stabilization of the jawbone, spinal fusion and bone fillers after tumor surgery. Potential future applications of calcium orthophosphate bioceramics are demonstrated in drug delivery systems, effective carriers of growth factors, bioactive peptides and/or various types of cells for tissue engineering purposes.

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“…Carbonate apatite (CAP) is resorbed by osteoclasts 1,2) and is similar in biocompatibility to hydroxyapatite (HAP) 3) and β-tricalcium phosphate (β-TCP) 4) . Although the bioresorption mechanism of CAP may be different from that of β-TCP 5) , CAP dissolves to the same extent as β-TCP in weak acid media 1) .…”

Section: Introductionmentioning

confidence: 99%

Superplastic Deformation in Carbonate Apatite Ceramics under Constant Compressive Loading for Near-net-shape Production of Bioresorbable Bone Substitutes

2008

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To produce carbonate apatite (CAP) ceramics with the desired complex shapes using superplastic deformation, deformation behavior of CAP ceramics under constant loading as well as physical properties after deformation were evaluated. Sintered CAP ceramics were plastically deformed in an electric furnace attached to a universal hydraulic testing machine under a constant load. CAP ceramics subjected to an initial compressive pressure of 10 MPa showed an appreciable amount of plastic deformation at temperatures ranging from 720 to 800℃. Plastic deformation increased with increasing temperature from about 10％ to 70％ after two hours of loading. X-ray diffraction analysis and SEM observation further revealed that some CAP crystals were elongated and aligned with the c-axis normal to the loading direction during superplastic deformation. It was thus concluded that a marked plastic deformation of about 70％ at 800℃ would be sufficient for near-net-shape production of bioresorbable CAP bone substitutes with complex shapes.

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Resorption of sintered synthetic hydroxyapatite by osteoclasts in vitro

Cited by 135 publications

References 4 publications

Initial interfacial healing events around calcium phosphate (Ca‐P) coated oral implants

Initial interfacial healing events around calcium phosphate (Ca‐P) coated oral implants

Medical Application of Calcium Orthophosphate Bioceramics

Superplastic Deformation in Carbonate Apatite Ceramics under Constant Compressive Loading for Near-net-shape Production of Bioresorbable Bone Substitutes

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