Considering the environment and human life, the importance of dangerous goods transportation should be carefully considered. Preventing damages during this transportation, anticipating the dangers, and minimizing the risks are vital components for businesses, human life, and the environment. Therefore, reducing/minimizing risks in dangerous goods transportation is a critical element of vital importance. This chapter is aimed to rate the risk factors related to dangerous goods transportation and select the most ideal warehouse locations due to the their importance for human and environmental health. There are a number of factors for that purpose. There are six provinces in the Eastern Black Sea region having the strategic function and structure. According to the decision makers' views and judgments, three provinces are determined in terms of dangerous goods transportation. Picture fuzzy sets-based AHP-TOPSIS methodology was used to analyze the problem of dangerous goods transportation and the most ideal warehouse location selection.