Recently, the ideas of wireless network coding (NC) has significantly enriched the area of wireless cooperation/relaying. They bring substantial gains in spectral efficiency mainly in scenarios with two-way relaying. Inspired by the ideas of wireless NC, recently we have proposed techniques for coordinated direct/relay (CDR) transmissions. Leveraging on the fact that the interference can be subsequently canceled, these techniques embrace the interference among the communication flows to/from direct and relayed users. Hence, by allowing simultaneous transmissions, spectral efficiency is increased. In our prior work, we have proposed CDR with Decode-and-Forward (DF) relay in two scenarios. In this paper, we extend the two existing regenerative CDR schemes and proposed for the other two scenarios such that all schemes benefit from the aforementioned principle of containing the interference. The parameters in the schemes are optimized to have the largest rate region or the highest sum-rate. Numerical results show that DF CDR is better than the reference scheme and almost better than AF CDR.