Resource utilization among kidney transplant recipients

Abstract

Identification of risk factors associated with increase resource utilization among kidney transplant recipients could aid in the development of targeted interventions to improve clinical and economic outcomes.

Infection-Related Hospitalization Rates in Pediatric versus Adult Patients with End-Stage Renal Disease in the United States

“…The IH rates for this national sample of 332,442 adult incident dialysis patients are similar to the 35% reported for a contemporary US adult HD cohort (6). Our IH rate of 39.8% over 3 yr in a national sample of 31,663 adult KTx patients is somewhat higher than the 18.5% reported in a single-center study of 220 adult KTx patients who received a transplant between 1990 and 1999 (8). However, infection also was the major cause of hospitalization for those study patients.…”

“…Previous studies reported IH rates in adults with ESRD to vary between 13 and 35% (5)(6)(7)(8)16). The IH rates for this national sample of 332,442 adult incident dialysis patients are similar to the 35% reported for a contemporary US adult HD cohort (6).…”

“…Mortality rates as a result of infection are higher in adult dialysis and kidney transplant (KTx) patients compared with the adult general population (4). Infection is a frequent cause of hospitalization in patients with ESRD (1,(5)(6)(7)(8)(9)(10)(11). Factors that lead to increased risk for infection in these patients include immune dysfunction, malnutrition, young or advanced age, comorbid conditions such as diabetes, vascular access devices, and immunosuppression (4,10 -15).…”

Managing Specialty Medication Services Through a Specialty Pharmacy Program: The Case of Oral Renal Transplant Immunosuppressant Medications

“…[42][43][44] We do not have that data field in our retrospective claims, which may influence comparison of medical utilization and costs. Specialty and retail cohorts were balanced for new users to therapy using transplant medication claims (4% and 3%, respectively) and number of patients with first transplant medication claims during days 1-90, 91-180, 181-270, and 271 onward during the index period, but ≥ 84% of patients were on medication at the beginning of the index period and potentially prior to the baseline period as well.…”

Clinical and Economic Outcomes of Rabbit Antithymocyte Globulin Induction in Adults Who Received Kidney Transplants from Living Unrelated Donors and Received Cyclosporine‐Based Immunosuppression

“…4,9 Acute rejection is also associated with substantial increases in treatment costs and hospitalizations. 10,11 As an approach to reduce the acute rejection rate, antibody induction is commonly used to intensify initial immunosuppression in kidney transplant recipients.…”