Respiratory Allergy: Hazard Identification and Risk Assessment

Briatico-Vangosa, G; Braun, C.; Cookman, Gillian R.; Hofmann, Thiemo; Kimber, Ian; Loveless, Scott E.; Morrow, Thomas; Pauluhn, Jürgen; Sørensen, Tom; Niessen, H.

doi:10.1006/faat.1994.1093

Cited by 72 publications

(43 citation statements)

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“…However, there is no conclusive evidence that animal models can predict the sensitizing potential of chemicals in humans (1,29). There is a reasonable agreement between the results from the present rat model and epidemiologic studies of exposed workers.…”

Section: Statisticssupporting

confidence: 60%

“…Thus interest in predictive testing of allergenicity (1,2) and in quantitative structureactivity relationships (3-6) is growing.…”

mentioning

confidence: 99%

“…Topical sensitization of mice followed by the registration of alterations of the serum concentration of immunoglobulin (Ig) E and differential cytokine production is another interesting approach (5,9,10). The induction of specific antibodies may be a sensitive indicator of respiratory sensitization (1).…”

mentioning

confidence: 99%

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Antibody responses of rats after immunization with organic acid anhydrides as a model of predictive testing

Zhang¹,

Welinder²,

Jönsson³

et al. 1998

Scand J Work Environ Health

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Section: Statisticssupporting

confidence: 60%

“…Thus interest in predictive testing of allergenicity (1,2) and in quantitative structureactivity relationships (3-6) is growing.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Antibody responses of rats after immunization with organic acid anhydrides as a model of predictive testing

Zhang¹,

Welinder²,

Jönsson³

et al. 1998

Scand J Work Environ Health

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“…Obviously, occupational exposure to nonallergenic agents may also influence IgE sensitization, e.g. to common aeroallergens, and atopies arc more susceptible to allergic mani festations in the presence of irritating agents [15,16], Nassif et al [17] reported that the skin of atopies is generally asso ciated with a lowered threshold o f irritant responsiveness towards sodium lauryl sulfate. In the present study we used neutrophils from nonatopic donors.…”

Section: Discussionmentioning

confidence: 99%

Dual Effect of Ammonium Persulfate on the Generation of Leukotrienes from Human Neutrophil Granulocytes

Köller¹,

Hilger²,

König³

1996

Int Arch Allergy Immunol

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Occupationally induced hypersensitive reactions towards chemical compounds are increasingly observed. In this regard ammonium persulfate (APS) is reported as an inducer of erythema, urticaria, eczema, rhinitis and bronchial asthma. On the basis of these reactions, persulfates obviously show some characteristics of skin-sensitizing as well as respiratory allergens. We measured the effect of APS on the release of inflammatory mediators, i.e. leukotriene B₄ (LTB₄), from human polymorphonuclear neutrophils (PMN). The effect of the persulfate was analyzed in comparison of the corresponding sulfate. After different cellular activation either with the Ca ionophore A23187, the tripeptide formyl-methionyl-leucyl-phenylalanine (fMLP) or sodium fluoride (NaF) coincubation of PMN with APS led to a diminished generation of LTB₄. In addition it was demonstrated that APS decreased the stability of leukotrienes in cell-free systems. However, cells which were preactivated with APS and subsequently washed showed an increase in leukotriene formation after stimulation with fMLP or NaF but not with the Ca ionophore. Thus, the concentration of APS at local tissue sites as well as the occurrence and nature of a secondary cell-activating stimulus finally determine to what extent persulfates will interfere with cellular functions, e.g. mediator suppression or induction, which are then responsible for clinical disease processes.

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“…To the extent that the potential of chemicals to cause immunological sensitisation depends on their mode of interaction with antigen-presenting cells and the subject9s subsequent lymphocyte responses, and since antigen-presenting cells and lymphocytes are not confined to the skin, there is no a priori reason to assume that the dermal route of administration is critical in eliciting a sensitisation response. Arguably, chemicals that are positive in tests involving dermal application should be considered as sensitisers regardless of their mode of contact with the body, including through inhalation [20]. This is contentious, and further research into the relationship between dermal and respiratory sensitisation is required.…”

Section: Preproduct Screeningmentioning

confidence: 99%

The prevention of occupational asthma

Cullinan

Tarlo²,

Nemery³

2003

Eur Respir J

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There is sufficient understanding of the causation of occupational asthma for preventive action to be appropriate. To date, attempts appear to have been largely unsuccessful and this appears to be largely due to nonscientific/technical obstacles. These include the fragmented nature of the disease, its low public and industrial profile, and its comparative rarity in single workplaces. Nonetheless the disease has high individual and societal costs.Prevention strategies should be concentrated on workplace-exposure controls, accompanied by intense educational and managerial improvements. Methods of secondary prevention appear to be successful but require considerable refinement. Screening (out) of potential new employees is inefficient and likely to remain so; and in any case is beset by difficult ethical and legal issues.There are only a handful of published studies reporting evaluations of preventive programmes. None is entirely rigorous but each suggests that primary and secondary prevention are both feasible and highly effective. The evaluation of preventive strategies is difficult, not only because of the low incidence of the disease in individual workplaces but also because of the failure of many epidemiologists to engage in this work. Considerably more cooperation between scientists in the field, regulatory authorities and industry is required.

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Respiratory Allergy: Hazard Identification and Risk Assessment

Cited by 72 publications

References 0 publications

Antibody responses of rats after immunization with organic acid anhydrides as a model of predictive testing

Antibody responses of rats after immunization with organic acid anhydrides as a model of predictive testing

Dual Effect of Ammonium Persulfate on the Generation of Leukotrienes from Human Neutrophil Granulocytes

The prevention of occupational asthma

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