Respiratory and sedative effects of clobazam and clonazepam in volunteers.

Abstract

1. The respiratory and psychomotor effects of two benzodiazepines used mainly as anticonvulsants were compared in healthy volunteers, using a double‐blind placebo controlled design. 2. Clobazam (10 and 20 mg) produced significantly fewer psychomotor side effects than clonazepam (0.5 and 1 mg). Neither drug at either dose affected the ventilatory response to CO2. 3. Although clonazepam produced significant effects on psychomotor performance, these did not correlate with plasma drug concentration. 4. Our studies provide further evidence that at the doses chosen clobazam is considerably less sedating than clonazepam. Further investigation is required into the tolerance profile of both drugs in patients.

Antihyperalgesic Effect of the GABAA Ligand Clobazam in a Neuropathic Pain Model in Mice: A Pharmacokinetic–Pharmacodynamic Study

“…Unlike other non-selective BZDs such as diazepam or clonazepam, which possess a 1-4 chemical structure, clobazam has a 1-5 chemical structure which may contribute to its better side effect profile [26]. However, the selectivity of clobazam has not been determined.…”

“…However, the selectivity of clobazam has not been determined. The reduced effect on psychomotor performance of clobazam (10 and 20 mg) compared with clonazepam (0.5 and 1 mg) was demonstrated in healthy volunteers [26] as well as, compared with lorazepam (1 mg), in anxious patients [20,21]. Our experiment corroborates these findings because the activity of the mice, recorded for 1 hr from the peak effect, was not significantly decreased at the dose of 3 mg/kg, which already displayed a notable antihyperalgesic effect.…”

An Observational Study of Drug Utilisation Pattern and Pharmacovigilance of Antipsychotics

“…Risperidone has been found to produce constipation in almost 29.41% of patients prescribed with the drug. Though, in general atypical antipsychotics are devoid of anticholinergic adverse effects, risperidone has been found to produce constipation and even paralytic ileus in many studies [32].…”

Additive Interactions between 1-Methyl-1,2,3,4-Tetrahydroisoquinoline and Clobazam in the Mouse Maximal Electroshock-Induced Tonic Seizure Model - An Isobolographic Analysis for Parallel Dose-Response Relationship Curves

“…It has selective affinity for the ω 2 site, where it has agonistic activity [23]. In a double-blind placebo-controlled trial published in 1990 comparing CLB to clonazepam, 10 or 20 mg of CLB was shown to be much less sedating than either 0.5 mg or 1 mg of clonazepam [24]. Additionally, the ω 1 receptor, which is found on the α 1 subtype of the GABA A receptor, was shown to be responsible for the sedative effects of diazepam [25].…”