Respiratory disease in foals and the epizootiology of equine herpesvirus type 2 infection

Fu, Zhen F.; Robinson, Anthony J.; Horner, G.W.; Dickinson, Loïs; Grimmett, J.B.; Marshall, R.B.

doi:10.1080/00480169.1986.35331

Cited by 41 publications

(18 citation statements)

References 12 publications

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“…The infection of the three English foals might occur later but by the age of 12 to 16 weeks EHV-2 DNA was detected in the PBLs. These findings support other results, where EHV-2 was detected in nasal specimens by cocultivation for as long as 2 to 6 months of age [13].…”

Section: Discussionsupporting

confidence: 93%

Prevalence of equine herpesvirus types 2 and 5 in horse populations by using type-specific PCR assays

Nordengrahn¹,

Mérza²,

Ros

et al. 2002

Vet. Res.

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-Equine herpesvirus types 2 and 5 (EHV-2 and EHV-5) have a rather unclear pathogenicity and distribution within the equid population. In order to gain more information on the prevalence of these two viruses, type-specific PCR assays were developed to detect viral DNA in nasal specimens and in peripheral blood leukocytes (PBLs) of adult horses and foals from various regions of Europe, i.e. Sweden, Hungary and the United Kingdom. In adult horses, the prevalence of EHV-2 in PBLs was up to 68% in Sweden and 71% in the United Kingdom. EHV-2 DNA was detected in the PBLs from all the foals tested in all countries and most (93%) of the nasal specimens also yielded positive results. The prevalence of EHV-5 DNA in the PBLs of foals in Hungary was 15 and 24% in adult horses in the United Kingdom. This observation was among the very few reports of the presence of EHV-5 in horses. In summary, the specific PCR assays revealed important data on the occurrence and distribution of EHV-2 and EHV-5 in large horse populations. The findings indicated that infection with EHV-5 occurred later than EHV-2 in foals. This study may contribute to a better understanding of the etiological role of these gammaherpesviruses in equine diseases. Chez les chevaux adultes, la prévalence de EHV-2 dans les LSP atteignait 68 % en Suède et 71 % au Royaume-Uni. L'ADN de EHV-2 a été détecté dans les LSP de tous les poulains testés, et la plupart (93 %) des prélèvements nasaux étaient également positifs. La préva-lence de l'ADN de EHV-5 dans les LSP des poulains en Hongrie était de 15 % et de 24 % chez les chevaux adultes au Royaume-Uni. Cette observation fait partie des très rares signalements de la présence de EHV-5 chez les chevaux. En résumé, les tests PCR spécifiques ont révélé des données importantes sur la présence et la distribution de EHV-2 et EHV-5 dans d'importantes populations de chevaux. Les résultats ont montré que l'infection par le EHV-5 se produisait plus tard que celle par le EHV-2 chez le poulain. Cette étude apporte une meilleure compréhension du rôle étiologique de ces herpesvirus gamma dans les maladies équines.infections équines / Gammaherpesvirinae / EHV-2 / EHV-5 / PCR

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Section: Discussionsupporting

confidence: 93%

Prevalence of equine herpesvirus types 2 and 5 in horse populations by using type-specific PCR assays

Nordengrahn¹,

Mérza²,

Ros

et al. 2002

Vet. Res.

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“…9,23,24 However, experimental infection with EHV-2 has yielded variable results, and the virus can be isolated from a high percentage of sick and healthy horses worldwide. [24][25][26][27][28][29][30] Unfortunately, even less is known about EHV-5 and its role in causing disease. One of the earliest reports 31 of EHV-5 isolation was from horses with disease of the upper portion of the respiratory tract in Australia.…”

Section: Discussionmentioning

confidence: 99%

Multinodular pulmonary fibrosis in five horses

Wong¹,

Belgrave²,

Williams³

et al. 2008

javma

160

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EMPF should be considered as a differential diagnosis for adult horses with interstitial pneumonia and should be suspected on the basis of characteristic radiographic, ultrasonographic, and histopathologic findings. Equine herpesvirus type 5 is found in association with EMPF; although the exact pathogenic role this virus plays in EMPF is unknown, equine herpesvirus type 5 may be an etiologic agent or cofactor in the development of EMPF.

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“…EHV-2 infection in young foals has been reported by others. 10,19 In the present study, samples were obtained from 11 foals from stable 1 3 times over a period of 6 months. All foals went through an active infection of EHV-2 (Fig.…”

Section: Discussionmentioning

confidence: 99%

The Use of a Neutralizing Monoclonal Antibody to Detect Infections of Equine Herpesvirus Type 2 (EHV-2)

et al. 2001

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Abstract.A blocking enzyme-linked immunosorbent assay (ELISA) was developed to detect antibodies to equine herpesvirus 2 in serum samples of horses. By measuring the binding to a single epitope, this blocking ELISA gives a good picture of the antibody status in the animal. The test is based on a monoclonal antibody with neutralizing activity and had a sensitivity of 94% and a specificity of 100%. Antibodies due to newly acquired infection in foals were successfully detected with this blocking ELISA.

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Respiratory disease in foals and the epizootiology of equine herpesvirus type 2 infection

Cited by 41 publications

References 12 publications

Prevalence of equine herpesvirus types 2 and 5 in horse populations by using type-specific PCR assays

Prevalence of equine herpesvirus types 2 and 5 in horse populations by using type-specific PCR assays

Multinodular pulmonary fibrosis in five horses

The Use of a Neutralizing Monoclonal Antibody to Detect Infections of Equine Herpesvirus Type 2 (EHV-2)

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