Respiratory distress in the neonate: Case definition &amp; guidelines for data collection, analysis, and presentation of maternal immunization safety data

Sweet, Leigh R.; Keech, Cheryl; Klein, Nicola P.; Marshall, Helen; Tagbo, Beckie Nnenna; Quine, D; Kaur, Pawandeep; Tikhonov, Ilia; Nisar, Muhammad Imran; Kochhar, Sonali; Muñoz, Flor M.

doi:10.1016/j.vaccine.2017.01.046

Cited by 57 publications

(52 citation statements)

References 45 publications

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“…Acute respiratory distress is a common disease in infants, with a morbidity rate of 7%. The incidence rate of acute respiratory distress is high in premature infants [ 1 ]. Although the 2015 Pediatric ALI Consensus Conference (PALICC) developed specific ARDS diagnostic criteria for children ranging in age from infants to adolescents (pARDS), preterm infants with lung disease and perinatal lung injury were excluded [ 2 ].…”

Section: Introductionmentioning

confidence: 99%

Rehmannia Radix Extract Relieves Bleomycin-Induced Pulmonary Fibrosis in Mice via Transforming Growth Factor β1 (TGF-β1)

Zhu

2020

Med Sci Monit

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Background Infants and young children with acute respiratory distress syndrome (ARDS) have acute progressive hypoxic respiratory failure caused by a variety of extrapulmonary pathogenic factors and cardiogenic factors. Diffuse alveolar injury and pulmonary fibrosis both are pathological features of ARDS. This study investigated the effect of Rehmannia Radix extract (RRE) on pulmonary fibrosis of infants with ARDS. Material/Methods The human lung fibroblasts cell line HFL1 was treated with various concentrations of Rehmannia Radix extract in different groups for different times. Flow cytometry and TUNEL assay were performed to detect cell apoptosis, and CCK8 assay was utilized to analyze cell proliferation. TGF-β1 expression was detected by real-time quantitative PCR, and protein-level expressions of Caspase3, TGF-β1, Bcl-2, and Smad3 were measured by western blot and immunohistochemical staining in cells or tissues. TGF-β1 was overexpressed by recombinant human TGF-β1 (2 ng/mL) and the treated cells and culture supernatant were harvested for analysis in each step. Bleomycin was used to induce a mouse model of pulmonary fibrosis and was confirmed by HE pathological sections. Results Flow cytometry and TUNEL results showed that RRE promoted the apoptosis of HFL1 cells in a concentration-dependent manner, and it inhibited the proliferation of HFL1 cells. Upregulation of TGF-β1 reversed the effects of RRE in HFL1 cells. RRE alleviated pulmonary fibrosis in mice through downregulating Bcl-2, TGF-β1, and Smad3 expression. Conclusions RRE promoted apoptosis and inhibited proliferation of HFL1, and then arrested the progression of pulmonary fibrosis. RRE had a significant inhibitory effect on TGF-β1 and Smad3. These results suggest that RRE directly prevents the development of pulmonary fibrosis by affecting the expression of TGF-β1 and Smad3.

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Section: Introductionmentioning

confidence: 99%

Rehmannia Radix Extract Relieves Bleomycin-Induced Pulmonary Fibrosis in Mice via Transforming Growth Factor β1 (TGF-β1)

Zhu

2020

Med Sci Monit

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“…This difference could be explained by the fact that the risk of RDS is inversely proportional to gestational age and birth weight; RDS occurs in approximately 5% of near-term infants, 30% of infants <30 weeks gestational age, and 60% of premature infants <28 weeks gestational age. 24 Gestational age is considered as an independent predictor of RDS. 25 Moreover, in a report from the National Institute of Child Health and Human Development Neonatal Research Network, the incidence of RDS was 44% in infants weighing 501-1500 g, with 71% reported in infants weighing 501-750 g, 54% reported in infants weighing 751-1000 g, 36% reported in infants weighing 1001-1250 g, and 22% reported in infants weighing 1251-1500 g. 26 In the study by Negi et al, 5 gestational age and birth weight were higher in control group than neonates with RDS.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity

et al. 2019

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We assessed oxidant-antioxidant status and evaluated the role of lipid peroxidation, oxidative DNA damage, and protein oxidation in the development and severity of neonatal respiratory distress syndrome (RDS). METHODS: Forty preterm neonates with RDS were compared with another 40 preterm neonates without RDS enrolled as controls. Total antioxidant capacity (TAC), malondialdehyde (MDA), advanced oxidation protein products (AOPPs), 8-hydroxy-2deoxyguanosine (8-OHdG), and trace elements (copper and zinc) were measured in cord blood (day 0) for all neonates and repeated on day 3 for the RDS group. RESULTS: Day 0 serum levels of MDA, AOPPs, and 8-OHdG were significantly higher in neonates with RDS than controls with a further increase on day 3. Days 0 and 3 levels of TAC, copper, and zinc were significantly lower in the RDS group compared with controls. Elevated serum levels of 8-OHdG and AOPPs were associated with severe RDS, invasive mechanical ventilation, and high mortality rate. 8-OHdG and AOPPs were positively correlated with MDA, oxygenation index, duration of ventilation, and duration of hospitalization. CONCLUSIONS: Increased lipid, protein, and DNA oxidation is accompanied by alterations in the antioxidant defense status, which may play a role in the pathogenesis and severity of RDS.

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“…Clinical characteristics appear shortly after delivery and include tachypnoea, nasal flaring and grunting 1–3. TTN is a common cause of respiratory distress in late preterm and term infants and is generally a benign disease treated with a brief course of oxygen 4–6. However, some patients develop severe respiratory distress immediately after birth and require invasive or non-invasive respiratory support 7 8…”

Section: Introductionmentioning

confidence: 99%

Association between uterine contractions before elective caesarean section and transient tachypnoea of the newborn: a retrospective cohort study

2020

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ObjectiveWe evaluated the association between the presence of predelivery uterine contractions and transient tachypnoea of the newborn (TTN) in women undergoing an elective caesarean section.DesignA retrospective cohort study.SettingNational Hospital Organization Kofu National Hospital, which is a community hospital, between January 2011 and May 2019.ParticipantsThe study included 464 women who underwent elective caesarean section. The exclusion criteria were missing data, twin pregnancy, neonatal asphyxia, general anaesthesia and elective caesarean section before term.Primary and secondary outcome measuresPatients were grouped according to the presence or absence of uterine contractions on a 40-min cardiotocogram (CTG) performed within 6 hours before caesarean delivery. We performed a multivariable logistic regression analysis to examine the association between predelivery uterine contractions and TTN.ResultsThe incidence of TTN was 9.9% (46/464), and 38.4% (178/464) of patients had no uterine contraction. The absence of uterine contractions was significantly associated with an increased risk of TTN (adjusted OR 2.04; 95% CI 1.09 to 3.82) after controlling for gestational diabetes mellitus, small for gestational age, male sex and caesarean section at 37 weeks.ConclusionsAccurate risk stratification using a CTG could assist in the management of infants who are at risk of developing TTN.

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Respiratory distress in the neonate: Case definition & guidelines for data collection, analysis, and presentation of maternal immunization safety data

Cited by 57 publications

References 45 publications

Rehmannia Radix Extract Relieves Bleomycin-Induced Pulmonary Fibrosis in Mice via Transforming Growth Factor β1 (TGF-β1)

Rehmannia Radix Extract Relieves Bleomycin-Induced Pulmonary Fibrosis in Mice via Transforming Growth Factor β1 (TGF-β1)

Oxidative stress markers in neonatal respiratory distress syndrome: advanced oxidation protein products and 8-hydroxy-2-deoxyguanosine in relation to disease severity

Association between uterine contractions before elective caesarean section and transient tachypnoea of the newborn: a retrospective cohort study

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