Respiratory Effects of Halothane in a Patient with Refractory Status Asthmaticus

Revich, Leopoldo R.; S, Grinspon; Paredes, Carlos; Moreno, Electra; Gené, Ricardo; Jorge, Miguel A.

doi:10.1006/pupt.2001.0309

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Therapeutic Options In Refractory Acute Severe Asthma1

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Cited by 4 publications

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“…Finally, there are isolated reports on possible beneficial bronchodilating effects of inhaled halogenated anes-thetics [76,77]. However, their use in ventilated asthmatics is logistically extremely cumbersome.…”

Section: Therapeutic Options In Refractory Acute Severe Asthmamentioning

confidence: 99%

Management of mechanical ventilation in acute severe asthma: practical aspects

et al. 2006

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We focus on the practical management of controlled hypoventilation. Particular attention must be paid to ventilator settings, monitoring of lung hyperinflation, the role of extrinsic PEEP, and administering inhaled bronchodilators. We also underline the importance of deep sedation with respiratory drive-suppressing opioids to maintain patient-ventilator synchrony while avoiding as much as can be muscle paralysis and the ensuing risk of myopathy. Finally, the role of noninvasive positive pressure ventilation for the treatment of respiratory failure during severe asthma is discussed.

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Section: Therapeutic Options In Refractory Acute Severe Asthmamentioning

confidence: 99%

Management of mechanical ventilation in acute severe asthma: practical aspects

et al. 2006

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Airway Pharmacology

Ball¹,

McGuire²

2013

Benumof and Hagberg's Airway Management

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Differential Effects of Volatile Anesthetics on M3Muscarinic Receptor Coupling to the GαqHeterotrimeric G Protein

Nakayama¹,

Penheiter

Penheiter³

et al. 2006

Anesthesiology

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The differential effects of volatile anesthetics on acetylcholine-promoted guanosine nucleotide exchange at Galphaq are consistent with the apparent more potent direct effect of halothane and sevoflurane compared with isoflurane on muscarinic receptor-mediated contraction of isolated airway smooth muscle. These differential effects also suggest a mode of anesthetic action that could be due to anesthetic-protein interactions and not simply anesthetic accumulation in the lipid membrane.

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Respiratory Effects of Halothane in a Patient with Refractory Status Asthmaticus

Cited by 4 publications

References 23 publications

Management of mechanical ventilation in acute severe asthma: practical aspects

Management of mechanical ventilation in acute severe asthma: practical aspects

Airway Pharmacology

Differential Effects of Volatile Anesthetics on M3Muscarinic Receptor Coupling to the GαqHeterotrimeric G Protein

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