Respiratory epithelial adenomatoid hamartoma in the nasopharynx

Metselaar, R M; Stel, H. V.; Baan, S. Van Der

doi:10.1258/0022215054273124

Cited by 30 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The bulk of the cases that have been reported have been in males in the third to ninth decades of life [2,6]. These masses occur in the nasal cavity, paranasal sinuses, and nasopharynx [2][3][4][5][6][7][8][9][10][11].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Respiratory Epithelial Adenomatoid Hamartoma: A Review

Fitzhugh

Mirani

2008

Head and Neck Pathol

View full text Add to dashboard Cite

Respiratory epithelial adenomatoid hamartoma (REAH) is an uncommon lesion of the upper aerodigestive tract first described by Wenig and Heffner in 1995 as prominent glandular proliferations lined by ciliated respiratory epithelium originating from the surface epithelium. The entity is seen most often in male adults. Clinically the lesion presents as a polypoid mass, often in one or both nasal cavities, though other locations have been described. While REAH is benign, awareness and recognition of the lesion is important because it can be easily confused grossly and microscopically with more threatening tumors such as inverted papilloma and sinonasal carcinoma. The literature of REAH is reviewed with detail paid to the histologic diagnosis. The clinical presentation, radiologic findings, and differential diagnosis are also described.

show abstract

Section: Introductionmentioning

confidence: 99%

“…To date, there is limited literature regarding REAH, and the majority has been published as case reports [3,4,[6][7][8][9][10][11][12][13][14][15][16]. Recent publications have expanded on the immunohistochemical and molecular genetic features of these lesions, which have assisted in their greater understanding [17,18].…”

Section: Introductionmentioning

confidence: 99%

Respiratory Epithelial Adenomatoid Hamartoma: A Review

Fitzhugh

Mirani

2008

Head and Neck Pathol

View full text Add to dashboard Cite

show abstract

“…It most commonly originates from the nasal septum and olfactory cleft. The rare origin sites of REAH are paranasal sinuses, nasopharynx, and middle and inferior turbinate (8,9). In our patient, the lesion originated from the medial part of the superior turbinate, which is the medial portion of the olfactory cleft.…”

Section: Discussionmentioning

confidence: 61%

“…In contrast, inflammatory nasal polyps show the proliferation of pseudostratified respiratory epithelium with basement membrane thickening and stromal fibroblast proliferation and edema, with strong eosinophil, lymphocyte, and plasma cell tissue infiltration. Glandular proliferation can be found in nasal polyposis, but abnormal submucosal proliferation of the surface respiratory epithelium is more typically observed in REAH (9,10). Although inverted papillomas often have a grossly polypoid appearance, they differ from "true" nasal polyps and REAHs.…”

Section: Discussionmentioning

confidence: 99%

Respiratory Epithelial Adenomatoid Hamartoma and Inflammatory Nasal Polyps Arising from the Different Sides of the Nasal Cavity: A Case Report

Perić¹,

Đurđević²

2017

Erciyes Med J

View full text Add to dashboard Cite

Respiratory epithelial adenomatoid hamartoma (REAH) is rare, non-neoplastic lesion characterized by an abnormal proliferation of the glandular part of the respiratory nasal mucosa. Occasionally, this polypoid mass can be bilaterally associated with inflammatory nasal polyps. We present a case of a 63-year-old woman with REAH that originated from the right-sided superior turbinate and that was associated with nasal polyposis of the left nasal cavity. Endoscopic examination results revealed a lobular, yellow, soft-tissue mass in the right nasal cavity and nasal polyps in the left nasal cavity. Therapy included complete excision. Histopathological examination results showed the characteristics of REAH in the right nasal cavity and inflammatory nasal polyps in the left nasal cavity. To our knowledge, only one case of simultaneous presentation of REAH and nasal polyps in opposite sides of the nasal cavity has been previously described. Appropriate cooperation between a rhinologist and pathologist enables a correct diagnosis of these rare and unusual lesions.

show abstract

“…The epithelial and mesenchymal hamartomas are uncommon in the head and neck region. Hamartomas have been described in the nasal cavity, nasopharnx, 10 oropharynx, 5 retropharyngeal, 6 hypopharynx, 7 larynx, 2 ear, 8 Eustachian tube 9 and the deep neck spaces. Intracranial lesions like the extracerebral glioneural hamartoma extending into the parapharyngeal space have also been described.…”

Section: Discussionmentioning

confidence: 99%

Diagnostic and Surgical Challenge in the Management of a Rare Tumor of Skull Base and Face

Kumar¹,

Saravanam²,

Senthil³

2011

International Journal of Head and Neck Surgery

View full text Add to dashboard Cite

Aim: We report a rare case of lateral skull base hamartoma. The diagnostic dilemma, the therapeutic challenge and the importance of interdisciplinary approach to decrease the morbidity has been discussed. Method: We report a rare case of a 48-year-old male with swelling over the left side of face and cheek for a duration of 12 years, who presented to us only for his cosmetic deformity and no functional impairment, after a thorough clinical examination and series of invasive and noninvasive investigations, was diagnosed to have a rare tumor hamartoma of skull base and face. A complete surgical excision without morbidity was made possible only by a multidisciplinary team approach. The investigation and surgical approach to reduce per operative morbidity has been discussed. Microscopic examination of the excised specimen with special staining techniques was conclusive for hamartoma. Patient has been on a regular follow-up for the last 2 years with no evidence of recurrence and functional compromise.Discussion: The rarity of the tumor, the difficulty in diagnosis, management and prognosis of hamartoma have been discussed. Conclusion:Hamartoma of the infratemporal fossa is a rare tumor and those originating in this surgically challenging site are even rarer. Further their close proximity to vital structures in head and neck poses a formidable challenge in their diagnosis and surgical management to achieve a good cosmetic and functional result.

show abstract

Respiratory epithelial adenomatoid hamartoma in the nasopharynx

Cited by 30 publications

References 0 publications

Respiratory Epithelial Adenomatoid Hamartoma: A Review

Respiratory Epithelial Adenomatoid Hamartoma: A Review

Respiratory Epithelial Adenomatoid Hamartoma and Inflammatory Nasal Polyps Arising from the Different Sides of the Nasal Cavity: A Case Report

Diagnostic and Surgical Challenge in the Management of a Rare Tumor of Skull Base and Face

Contact Info

Product

Resources

About