Respiratory Epithelial Adenomatoid Hamartoma (REAH) in the Olfactory Cleft: Often Masked by Bilateral Nasal Polyps

Shanbag, Raghunath; Patil, Prakash; Rani, S. Hephzibah; Kulkarni, Sughosh S.

doi:10.1007/s12070-018-1562-6

Cited by 8 publications

(3 citation statements)

References 27 publications

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“…They can arise anywhere in the sinonasal epithelium, but, usually, around 70% of REAH cases arise from the posterior nasal septum. However, they can also occur in other common sites such as the nasopharynx, lateral nasal wall, olfactory cleft, and frontal, maxillary, and ethmoid sinuses and are predominantly unilateral in presentation [7,8]. In our case, the patient had a bilateral nasal presentation, which is quite rare.…”

Section: Discussionmentioning

confidence: 69%

Respiratory Epithelial Adenomatoid Hamartoma in a Young Female: A Diagnostic Dilemma

Mujeeb,

Singavarapu,

Chaganti

et al. 2023

Cureus

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Hamartomas are non-neoplastic tissue abnormalities commonly found in various organs but rarely in the upper aerodigestive tract. Respiratory epithelial adenomatoid hamartoma (REAH) is a rare benign proliferation affecting the nasal cavity and sinonasal tract. It often mimics other nasal masses, leading to diagnostic challenges. We present the case of a 25-year-old female with recurrent epistaxis and chronic bilateral nasal obstruction. Diagnostic endoscopy revealed a polypoidal mass, later confirmed as REAH through histopathological examination. CT scans demonstrated soft tissue opacity but no erosion of surrounding bony structures. The patient underwent endoscopic excision, and the excised mass exhibited characteristic histological features of REAH. Endoscopic excision with careful postoperative follow-up can lead to successful outcomes in REAH cases. A year of follow-up revealed no recurrence.

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Section: Discussionmentioning

confidence: 69%

Respiratory Epithelial Adenomatoid Hamartoma in a Young Female: A Diagnostic Dilemma

Mujeeb,

Singavarapu,

Chaganti

et al. 2023

Cureus

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“…В полости носа РЭАГ чаще встречается у мужчин старше 30 лет и располагается в обонятельной области задних отделов носовой перегородки, хотя сообщалось также о поражении латеральной стенки полости носа, решетчатых, лобных пазух и носоглотки [21,22]. Этиология возникновения образования в настоящее время до конца не изучена [23]. Но ассоциация с полипами носа и аллергическим риносинуситом подтверждает гипотезу о том, что воспаление может быть одним из индуцирующих факторов РЭАГ [9], что отмечено и в нашем наблюдении.…”

Section: Discussionunclassified

Respiratory epithelial adenomatoid hamartoma in a child with nasal polyposis. Case report

Baranov,

Kotova,

Vyazmenov

et al. 2024

Consilium Medicum

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Benign and malignant formations of the nose and paranasal sinuses in the early stages of development are asymptomatic or manifest minor nonspecific signs, and therefore often remain unrecognized. Hamartoma is a tumor-like formation of a dysembriological nature, consisting of excessive tissues peculiar to the affected organ. Due to the rarity of the occurrence of hamartomas of the sinonasal region, especially in pediatric practice, their diagnosis may present certain difficulties, since they can mimic other formations, such as nasal polyps or inverted papilloma, may occur as an isolated formation in the nasal cavity, or in combination with chronic rhinosinusitis, nasal polyposis, allergic rhinosinusitis. Aim – to report a rare clinical case in pediatric practice of respiratory epithelial adenomatoid hamartoma associated with allergic rhinosinusitis and polyposis, display the relationship between the occurrence of respiratory epithelial adenomatoid hamartoma and chronic inflammation of the nasal cavity and paranasal sinuses, to carry out differential diagnosis with other exophytic aggressive lesions of the nasal cavity, combine and summarize available data on sinonasal hamartomas. The article describes a clinical case of respiratory epithelial adenomatoid hamartoma in a 17-year-old child with a previous 4-year follow-up with nasal cavity polyposis and a history of repeated polypotomy. The results of endoscopy and computed tomography of the nasal cavity and paranasal sinuses, the results of surgical intervention, as well as the conclusions of a histological examination of the tumor removed from the patient are presented. The authors analyzed the domestic and foreign literature, on the basis of which they presented a differential series of sinonasal hamartomas. Respiratory epithelial adenomatoid hamartoma is a rare pathological formation of the sinonasal region, which manifests itself as an isolated polypoid mass in the nasal cavity or as an accidental surgical finding in patients with chronic sinusitis. The association with nasal polyps supports the hypothesis that inflammation may be one of the inducing factors. Respiratory epithelial adenomatoid hamartoma, although rare, should be considered in the differential diagnosis of exophytic lesions of the nasal cavity. The tactics of treatment involves endoscopic removal of the formation within healthy tissues, which provides good long-term results, relapses are extremely rare.

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“…In recent reviews, it is apparent that the lesions arise more commonly at the olfactory cleft. 4,6 Lesions in the nasopharynx are still rarely described in the literature and in most cases, a more sinister diagnosis was initially suspected in lesions which extended into the nasopharynx, especially in patients who had significant other comorbid diseases. 3,7,8 Of the 394 cases included in a review by Nguyen et al there was only one case described to occur in the nasopharynx.…”

Section: Discussionmentioning

confidence: 99%

Nasopharyngeal Respiratory Epithelial Adenomatoid Hamartoma—Master of Masquerade

D’Oliveiro

Chong

2023

Ann Otol Rhinol Laryngol

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Objectives: To highlight a case of nasopharyngeal Respiratory Epithelial Adenomatoid Hamartoma (REAH) in a female patient with chronic nasal block. Methods: A single case report of a female patient with the diagnosis of REAH, detailing her presenting symptoms, clinical findings, management and follow up. Results: Histopathological assessment of the excised nasopharyngeal polyp was consistent with a diagnosis of REAH with a discussion on the disease and its current literature reviews. Conclusion: The incidence of REAH within the nasopharynx remain rare with only few cases described in literature, especially in females.

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Respiratory Epithelial Adenomatoid Hamartoma (REAH) in the Olfactory Cleft: Often Masked by Bilateral Nasal Polyps

Cited by 8 publications

References 27 publications

Respiratory Epithelial Adenomatoid Hamartoma in a Young Female: A Diagnostic Dilemma

Respiratory Epithelial Adenomatoid Hamartoma in a Young Female: A Diagnostic Dilemma

Respiratory epithelial adenomatoid hamartoma in a child with nasal polyposis. Case report

Nasopharyngeal Respiratory Epithelial Adenomatoid Hamartoma—Master of Masquerade

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