Respiratory infection caused by Flavobacterium meningosepticum

Fujita, Jiro; Hata, Yoshiya; Irino, Shôzo

doi:10.1016/0140-6736(90)90780-9

Cited by 13 publications

(8 citation statements)

References 2 publications

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“…The role of E. meningoseptica in nosocomial infections, particularly among immunocompromised patients with severe underlying disease, has been raised continuously in previous reports, even though these infections are considered uncommon in adults. [7][8][9][10][11]13] However, information on the clinical significance and treatment outcomes in adults with E. meningoseptica nosocomial infection has…”

Section: Discussionmentioning

confidence: 99%

“…[2,3] [3] Although most reports of E. meningoseptica infection in humans have been presented as meningitis outbreaks in premature newborns and infants, [4][5][6] several reports have emphasized its importance as a nosocomial infection in adult patients with severe underlying disease. [7][8][9][10][11] However, studies evaluating the clinical significance and treatment outcomes in adult patients with E. meningoseptica infection are rare.…”

Section: Introductionmentioning

confidence: 99%

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Experience with Elizabethkingia meningoseptica Infection in Adult Patients at a Tertiary Hospital

Joo¹,

Ann²,

Ryou³

et al. 2015

Korean J Crit Care Med

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Background: Few reports have documented the clinical characteristics and treatment outcomes of adult patients with Elizabethkingia meningoseptica infection. Methods: Medical records of patients over 18 years of age and suspected of having an E. meningoseptica infection from March 1, 2006 to February 28, 2013 were reviewed retrospectively. Their clinical characteristics, antimicrobial susceptibility results, and treatment outcomes were analyzed. Results: E. meningoseptica was isolated from 30 patients. Median age was 68.5 years, and infections were more frequent in males (17, 56.7%). The most common isolation source was sputum (23, 76.7%), and pneumonia was the most common condition (21, 70%) after excluding two cases of colonization. This bacterium was most susceptible to minocycline (27, 90%) and fluoroquinolones, including levofloxacin (20, 66.7%) and ciprofloxacin (18, 60%). The mortality rate due directly to E. meningoseptica infection was 20% (6/30), and uncontrolled pneumonia was the only cause of death. After isolating E. meningoseptica, the numbers of patients with pneumonia (9/9, 100% vs. 12/21, 57.1%), history of hemodialysis (5/9, 55.6% vs. 3/21, 14.3%), tracheostomy (8/9, 88.9 vs. 10/21, 47.6%), and median Charlson comorbidity index score (6 [range, 3-9] vs. 4 [range, 0-9]) were significantly higher in non-survivors than those in survivors (p < 0.05, for each). However, only 12 (40%) patients received appropriate antibiotics. Conclusions: E. meningoseptica infection most commonly presented as pneumonia in adults with severe underlying diseases. Despite the high mortality rate, the rate of appropriate antibiotic use was notably low.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Experience with Elizabethkingia meningoseptica Infection in Adult Patients at a Tertiary Hospital

Joo¹,

Ann²,

Ryou³

et al. 2015

Korean J Crit Care Med

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“…This is in accordance with previous studies. 5 As suggested before, 19 the isolation of F. meningosepticum from these patients may be due to the selection of highly resistant bacteria resulting from overuse of antibiotics. The high resistance seen in our isolates to (β-lactam antibiotics supports this suggestion.…”

Section: Discussionmentioning

confidence: 99%

“…[11][12][13]19,20 Like our group of patients, most of the patients reported before were under intensive care and had prolonged mechanical ventilation. 12,13,20 Previous investigators 12,20 found difficulty deciding whether F. meningosepticum isolates were infecting or colonizing the respiratory tract.…”

Section: Discussionmentioning

confidence: 99%

Flavobacterium Meningosepticumin Intensive Care Units of a Teaching Hospital in Riyadh, Saudi Arabia

et al. 1997

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“…The Flavobacteria are commonly present in fresh or sea water and in soil and foodstuffs, but are not recognised as normal human intestinal flora. Flavobacterium meningosepticum is undoubtedly pathogenic to man and is a known cause of meningitis in neonates [13,181 and of pneumonia in adults [7]. Alkaligenes are often found in human faeces and may cause bacteraemia [17].…”

Section: The Effect Of Warm Ischaemia and Denervationmentioning

confidence: 99%

Effect of small bowel transplantation, denervation and ischaemia on rat intestinal microflora

et al. 1994

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The effects of denervation and warm ischaemia on quantitative and qualitative changes in small intestinal microflora following rat heterotopic small-bowel isotransplantation were assessed. Animals with Thiry-Vella fistula, but without transplants, acted as controls. Thirty and 40-fold increases in bacterial colony counts were seen in the isografts compared to controls at 2 and 7 days, respectively (P < 0.05). Aerobic faecal organisms predominated at 2 and 7 days, but an overgrowth of Flavobacterium meningosepticum occurred at 28 days in the transplanted and host bowels. The effect of warm ischaemia on intestinal microflora was assessed by the application of a microvascular clamp to the superior mesenteric artery for 90 min. The effect of denervation was assessed following microsurgical division of all nervous tissue around the superior mesenteric artery. After 7 days, lengths of jejunum and ileum were removed and intraluminal microflora assessed. The number of bacterial colonies isolated from the ileum in the warm ischaemia group was six times greater than the number in the control group, whereas no significant changes were seen in the upper bowel. In contrast, denervation led to a slight, but consistent, decrease in colony counts. These findings suggest that the increase in bacterial numbers in an isografted small bowel primarily results from warm ischaemia rather than from mesenteric denervation, and that physical aspects of the procedure may affect the development of sepsis following small-bowel transplantation.

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Respiratory infection caused by Flavobacterium meningosepticum

Cited by 13 publications

References 2 publications

Experience with Elizabethkingia meningoseptica Infection in Adult Patients at a Tertiary Hospital

Experience with Elizabethkingia meningoseptica Infection in Adult Patients at a Tertiary Hospital

Flavobacterium Meningosepticumin Intensive Care Units of a Teaching Hospital in Riyadh, Saudi Arabia

Effect of small bowel transplantation, denervation and ischaemia on rat intestinal microflora

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