Respiratory Metabolism of Parasitic Helminths without Participation of the Cytochrome System

Bueding, Ernest; Charms, Bernard L.

doi:10.1038/167149a0

Cited by 21 publications

(5 citation statements)

References 7 publications

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“…Laser (1944) has found that cyanide can cause an increase in respiratory activity. Charms, 1952). However, a pigment with the same absorption maxima as reduced cytochrome c has been demonstrated spectroscopically in tissues of Parascaris equorum and A. lumbricoides (Keilin, 1925) and in those of A. lumbricoides at the temperature of liquid air (Keilin and Hartree, 1949).…”

Section: Cytochrome Systemmentioning

confidence: 99%

“…However, a pigment with the same absorption maxima as reduced cytochrome c has been demonstrated spectroscopically in tissues of Parascaris equorum and A. lumbricoides (Keilin, 1925) and in those of A. lumbricoides at the temperature of liquid air (Keilin and Hartree, 1949). Thus the conclusion that these parasitic nematodes have a unique terminal electron transport system (Bueding and Charms, 1952) remains open to question.…”

Section: Cytochrome Systemmentioning

confidence: 99%

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Tissue respiration in invertebrates

Bliss¹,

Skinner²

1963

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Effect: Stability of rate of esterification of phosphate in suspension to which DNP has been added; suggests that the phosphorylations result from anaerobic reactions; this effect noted in: Mollusca Gastropoda Helix pomatia: Midgut gland; Rees, 1953 CARBON MONOXIDE (CO) Effect: Photoreversible inhibition of respiration, i.e., inhibition of respiration by CO in darkness but not in light; strongly suggests the involvement of cytochrome oxidase in the electron transport system; this effect noted in:

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Section: Cytochrome Systemmentioning

confidence: 99%

Section: Cytochrome Systemmentioning

confidence: 99%

Tissue respiration in invertebrates

Bliss¹,

Skinner²

1963

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“…The cytochrome system, for instance, had been reported to be different from the classical mammalian type. Muscle and reproductive tissues of Ascaris and L. carinii had no measurable cytochrome c or cytochrome oxidase (Bueding & Charms, 1952). Ascaris was later reinvestigated using sensitive techniques and shown to contain the multiple terminal oxidases cytochrome a3, cytochrome o and cytochrome a, (Cheah, 1976).…”

Section: Introductionmentioning

confidence: 99%

Oxidative activities in mitochondria-like particles from Setaria digitata, a filarial parasite

Raj

Puranam

Kurup

et al. 1988

Biochemical Journal

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The oxidative metabolic potential of Setaria digitata, a filarial parasite found in the intraperitoneal cavity of cattle, was investigated. These worms showed active wriggling movements which were not affected by respiratory poisons such as cyanide, rotenone and malonate. They also possessed cyanide-insensitive and glucose-independent oxygen consumption pathways. By differential centrifugation of sucrose homogenates, a fraction containing mitochondria-like particles was obtained in which the activity of the marker enzyme, succinate dehydrogenase, was recovered. This fraction catalysed succinate- and NADH-dependent reduction of both cytochrome c and dyes. Oxygen uptake found with succinate, NADH and ascorbate as substrates was not sensitive to cyanide. Cytochromes could not be detected in either this fraction or homogenates of the worms. H2O2 generation with a number of substrates and lipid peroxidation by measuring malondialdehyde formed as well as by accompanying oxygen uptake were demonstrated in the mitochondria-like particles. A lipid quinone, possibly with a short side chain and related to ubiquinone, was detected in the worms. The results suggested the existence of two cyanide-insensitive oxygen-consuming reactions in Setaria: one respiratory substrate-independent lipid peroxidation, and a second substrate-dependent reaction that requires an auto-oxidizable quinone but not a cytochrome system.

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“…It may be that this reflects an earlier stage in their evolution in which they occupied a more anaerobic site within the host. A weak cytochrome system has been demonstrated, and it seems that such a terminal oxidase system (Bueding & Charms 1951) is unimportant. Until recently it was thought that an aerobic conversion of pyruvate to carbon dioxide and water was also superfluous and the Krebs tricarboxylic acid cycle was either absent or restricted, but we have recently demonstrated several of the enzymes involved in aerobic glycolysis using polyacrylamide gel electrophoresis (Fripp 1970).…”

mentioning

confidence: 99%

Biochemical Aspects of Schistosome Behaviour

Fripp

1972

Zoologica Africana

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The haematophagous blood trematodes that comprise the genus SchistosomJJ live in a stable environment with an adequate food supply and an efficient waste disposal system. The main food is glucose obtained from the host blood and assimilated through the tegument Other dietary factors are assimilated through the tegument or the gut epithelium. The male fluke supplements and augments the diet of the female who is thus able to concentrate on egg production. Live flukes resist attack by the host by secreting an immunologically inert envelope and by incorporating unchanged host serum protein into their structures. They can also incorporate host structural fatty acids unchanged.

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Respiratory Metabolism of Parasitic Helminths without Participation of the Cytochrome System

Cited by 21 publications

References 7 publications

Tissue respiration in invertebrates

Tissue respiration in invertebrates

Oxidative activities in mitochondria-like particles from Setaria digitata, a filarial parasite

Biochemical Aspects of Schistosome Behaviour

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