Respiratory modulation of heart rate in newborn infants

Hathorn, M.

doi:10.1016/0378-3782(89)90050-9

Cited by 21 publications

(7 citation statements)

References 24 publications

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“…Values for RR and HRV variables obtained in SGA newborns are close to those described in premature infants (16,37,38). Recent data from Peirano and Monod (39) demonstrate persistent HR pattern modification in SGA infants at 13 wk postnatal age.…”

Section: Discussionsupporting

confidence: 78%

“…Each 512-hb epoch was processed by the short-time Fourier transform, a nonstationary spectral analysis procedure that provides "instantaneous" evaluation of spectral amplitude in a given frequency band (16,22). We studied three frequency bands: 1) HF (variations with the period ranging from 3 to 8 hb); 2) MF (the period from 10to 25 hb); and 3) LF (the period from 30 to 100 hb), which have been previously described (16,22).…”

mentioning

confidence: 99%

“…We studied three frequency bands: 1) HF (variations with the period ranging from 3 to 8 hb); 2) MF (the period from 10to 25 hb); and 3) LF (the period from 30 to 100 hb), which have been previously described (16,22).…”

mentioning

confidence: 99%

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Heart Rate and Heart Rate Variability during Sleep in Small-for-Gestational Age Newborns

et al. 1994

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Section: Discussionsupporting

confidence: 78%

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confidence: 99%

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Heart Rate and Heart Rate Variability during Sleep in Small-for-Gestational Age Newborns

et al. 1994

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“…Thus, in PREM infants, the shortfall in the increase of HF HRV during quiet sleep may represent immaturity of the parasympathetic system. ANS maturity needs to be evaluated in quiet sleep for a standardized level of vagal tone as it is optimally stimulated by regular ventilatory activity [9], and presents minimal sympathetic inhibition. Some hypotheses have been formulated to explain CNS maturation delays involving different structures: cardiac and large vessel innervation, neurotransmitter synthesis, release and degradation as well as cell receptor efficiency [12].…”

Section: Discussionmentioning

confidence: 99%

Birth prematurity determines prolonged autonomic nervous system immaturity

et al. 2004

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Because of its multiple involvement in physiological processes, autonomic nervous system (ANS) activity, a key regulator of homeostatic control, demonstrates a progressive increase during pregnancy. The profile of its maturation, mainly in the parasympathetic arm, in premature or full term infants, may help us to better understand its pathophysiological role. We prospectively evaluated ANS maturity in a group of 23 premature (PREM) infants at their theoretical term age and in 8 full term (FT) newborns. All recordings were registered close to the theoretical full term period (from 38 to 41 weeks) for the PREM group and during the first week of life for the FT newborns. Polygraphic recordings, EEG monitoring associated with visual clinical control, and Holter ECG, were performed simultaneously. ANS indices were then calculated during quiet sleep periods, using Wavelet transform of RR (beat to beat) intervals. High frequency components were found to be significantly lower in the PREM than in the FT group (p<0.05). Furthermore, at theoretical full term age, the greater the prematurity, the lower was parasympathetic activity. Because it is easy, monitoring of parasympathetic activity may help us to understand autonomic maturation and its clinical prognostic implications.

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“…Thus, RDS severity is not likely to be the main cause for the negative correlation between aVR and aRSA. A more likely explanation is the occurrence of entrainment between baroreflex-related heart rate oscillations and RSA as found in spontaneously breathing adults (15) and newborns (8,24). Entrainment between respiratory-and baroreflex-related oscillations occurs if the respiratory rate approaches 0.07 Hz in newborns.…”

Section: 208mentioning

confidence: 98%

The Influence of Artificial Ventilation on Heart Rate Variability in Very Preterm Infants

et al. 1995

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To study the influence of artificial ventilation rate on neonatal heart rate variability (HRV), ECG and respiratory impedance curves were recorded four times a day in 20 preterm infants (<33 wk) during the first 3 d after birth while the infants were ventilated at a wide range of ventilator rates. The contents of selected frequency bands within the R-R interval power spectrum were calculated for 3-min periods. Respiratory distress syndrome severity was assessed at each measurement. Respiratory sinus arrhythmia (RSA) induced by the ventilator appeared to mimic spontaneous RSA. As in spontaneous respiration, the amount of RSA (power in a frequency band around the respiratory rate) increases as the ventilation rate decreases. This phenomenon is most probably due to entrainment with baroreflex-related fluctuations in the heart rate. Although the artificial ventilation rate influences RSA and thus high-frequency HRV, an increase in respiratory distress syndrome severity results in a decrease in low-frequency HRV. Thus, the attenuation of low-frequency HRV by respiratory distress syndrome is not likely to be due to artificial ventilation. (Pediatr Res 37: 124-130, 1995) Abbreviations aRSA, artificial respiratory sinus arrhythmia aVR, artificial ventilation rate HF, high-frequency HRV, heart rate variability LF, low-frequency RDS, respiratory distress syndrome RSA, respiratory sinus arrhythmia VLF, very LF HRV, i.e. the variation in beat-to-beat R-R interval length, is influenced by maturational (e.g. gestational age), physiologic (e.g. respiration), and clinical factors (1, 2). HRV can be assessed by spectral analysis to study the frequency-specific oscillations in the heart rate signal. In the newborn, the following heart rate oscillations may be present. HF oscillations have a frequency equal to the respiratory rate and are known as RSA. LF oscillations are due to intrinsic oscillations of the baroreceptor reflex loop with a frequency of 0.07 Hz (3). A second kind of LF oscillation may result from periodic fluctuations in respiratory depth or tidal volume (4). The last type of HRV features VLF oscillations with a frequency below 0.04 Hz. These are ascribed to thermoregulation. H F oscillations are mediated by the parasympathetic system. LF and VLF oscillations are mediated by both the sympathetic and parasympathetic systems (5). Thus, studying neonatal HRV can give an insight into the maturation of the autonomic nervous system.In newborns suffering from RDS, HRV appears to be atten- HRV returns to normal (2). Several explanations have been proposed for this reversible effect of RDS on HRV. For instance, it has been ascribed to transient depression of the medulla oblongata by hypercarbia (2). The possible influence of artificial ventilation as such on neonatal HRV has not been taken into account in studies regarding the influence of RDS. For the correct interpretation of HRV in infants with RDS, insight into the effect of artificial ventilation on HRV is needed. This influence cannot be studied by simply comparing...

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Respiratory modulation of heart rate in newborn infants

Cited by 21 publications

References 24 publications

Heart Rate and Heart Rate Variability during Sleep in Small-for-Gestational Age Newborns

Heart Rate and Heart Rate Variability during Sleep in Small-for-Gestational Age Newborns

Birth prematurity determines prolonged autonomic nervous system immaturity

The Influence of Artificial Ventilation on Heart Rate Variability in Very Preterm Infants

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