Respiratory response to baroreceptor stimulation and spontaneous contractions of the urinary bladder

Stella, Martha H.; Knuth, Susan L.; Bartlett, D.

doi:10.1016/s0034-5687(00)00215-2

Cited by 11 publications

(7 citation statements)

References 22 publications

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“…Our data provide a neural substrate for the expiratory– facilitatory response to activation of baroreceptors (Brunner et al, 1982; Dove and Katona, 1985; Grunstein et al, 1975; Li et al, 1999a,b; Lindsey et al, 1998; Nishino and Honda, 1982; Richter and Seller, 1975; Speck and Webber, 1983; Stella et al, 2001). We clearly demonstrate that barostimulation activates post-I neurones and depresses aug-E neurones.…”

Section: Discussionmentioning

confidence: 77%

Effect of baroreceptor stimulation on the respiratory pattern: Insights into respiratory–sympathetic interactions

Baekey

Molkov

Paton

et al. 2010

Respiratory Physiology & Neurobiology

143

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Sympathetic nerve activity (SNA) is modulated by respiratory activity which indicates the existence of direct interactions between the respiratory and sympathetic networks within the brainstem. Our experimental studies reveal that TE prolongation evoked by baroreceptor stimulation varies with respiratory phase and depends on the pons. We speculate that the sympathetic baroreceptor reflex, providing negative feedback from baroreceptors to the rostral ventrolateral medulla and SNA, has two pathways: one direct and independent of the respiratory–sympathetic interactions and the other operating via the respiratory pattern generator and is hence dependent on the respiratory modulation of SNA. Our experimental studies in the perfused in situ rat preparation and complementary computational modelling studies support the hypothesis that baroreceptor activation during expiration prolongs the TE via transient activation of post-inspiratory and inhibition of augmenting expiratory neurones of the Bötzinger Complex (BötC). We propose that these BötC neurones are also involved in the respiratory modulation of SNA, and contribute to the respiratory modulation of the sympathetic baroreceptor reflex.

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Section: Discussionmentioning

confidence: 77%

Effect of baroreceptor stimulation on the respiratory pattern: Insights into respiratory–sympathetic interactions

Baekey

Molkov

Paton

et al. 2010

Respiratory Physiology & Neurobiology

143

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“…The unified model defines a neural substrate for the expiratory-facilitatory response to activation of baroreceptors (Brunner et al, 1982; Dove and Katona, 1985; Grunstein et al, 1975; Li et al, 1999a,b; Lindsey et al, 1998; Nishino and Honda, 1982; Richter and Seller, 1975; Speck and Webber, 1983; Stella et al, 2001) and explains previous experimental findings that respiratory neurons, preferentially expiratory neurons, are modulated with the arterial pulse (Dick and Morris, 2004; Dick et al, 2005). This substrate can be used for further extending the model to incorporate interactions with the parasympathetic nervous system, since baroactivated post-I neurons were also found to be crucially involved in the modulation of cardiac vagal motoneurons (Gilbey et al, 1984).…”

Section: Unified Theoretical Framework For Respiratory–sympathetic mentioning

confidence: 76%

Physiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system

Molkov¹,

Zoccal²,

Baekey³

et al. 2014

Progress in Brain Research

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Respiratory modulation seen in the sympathetic nerve activity (SNA) implies that the respiratory and sympathetic networks interact. During hypertension elicited by chronic intermittent hypoxia (CIH), the SNA displays an enhanced respiratory modulation reflecting strengthened interactions between the networks. In this chapter, we review a series of experimental and modeling studies that help elucidate possible mechanisms of sympatho-respiratory coupling. We conclude that this coupling significantly contributes to both the sympathetic baroreflex and the augmented sympathetic activity after exposure to CIH. This conclusion is based on the following findings. (1) Baroreceptor activation results in perturbation of the respiratory pattern via transient activation of postinspiratory neurons in the Bötzinger complex (BötC). The same BötC neurons are involved in the respiratory modulation of SNA, and hence provide an additional pathway for the sympathetic baroreflex. (2) Under hypercapnia, phasic activation of abdominal motor nerves (AbN) is accompanied by synchronous discharges in SNA due to the common source of this rhythmic activity in the retrotrapezoid nucleus (RTN). CIH conditioning increases the CO2 sensitivity of central chemoreceptors in the RTN which results in the emergence of AbN and SNA discharges under normocapnic conditions similar to those observed during hypercapnia in naïve animals. Thus, respiratory–sympathetic interactions play an important role in defining sympathetic output and significantly contribute to the sympathetic activity and hypertension under certain physiological or pathophysiological conditions, and the theoretical framework presented may be instrumental in understanding of malfunctioning control of sympathetic activity in a variety of disease states.

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“…On the other hand, the modulatory influence of cardiovascular parameters on respiratory neuronal activity has not been widely recognized, despite numerous reports concerning barorespiratory reflexes (7,13,19,21,22,25,28,29,32,36,38,40) and the known modulatory effects of baroreceptor stimulation on medullary respiratory activity (2,9,17,21,22,25,32). The barorespiratory reflex has been described as acute increases in blood pressure leading to decreased respiratory frequency and tidal volume (8,13,19,29).…”

Section: Discussionmentioning

confidence: 99%

Arterial pulse modulated activity is expressed in respiratory neural output

Shannon¹,

Lindsey²,

Nuding³

et al. 2005

Journal of Applied Physiology

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Morris. Arterial pulse modulated activity is expressed in respiratory neural output. J Appl Physiol 99: [691][692][693][694][695][696][697][698] 2005. First published March 10, 2005; doi:10.1152/japplphysiol.01124.2004.-Although it is well-established that sympathetic activity is modulated with respiration, it is unknown whether neural control of respiration is reciprocally influenced by cardiovascular function. Even though previous studies have suggested the existence of pulse modulation in respiratory neurons, they could not exclude the possibility that such cells were involved in cardiovascular rather than respiratory motor control, owing to neuroanatomic and functional overlaps between brain stem neurons involved in respiratory and cardiovascular control. The aim of this study was to test the hypothesis that respiratory motoneurons and putative premotoneurons are modulated by arterial pulse. An existing data set composed of 72 well-characterized, respiratory-modulated brain stem motoneurons and putative premotoneurons was analyzed using ␦ 2 , a recently described statistic that quantifies the magnitude of arterial pulse-modulated spike activity [Dick TE and Morris KF. J Physiol 556: 959 -970, 2004]. Neuronal activity was recorded in the rostral and caudal ventral respiratory groups of 19 decerebrate, neuromuscular-blocked, ventilated cats. Axonal projections were identified by rectified and unrectified spike-triggered averages of recurrent laryngeal nerve activity or by antidromic activation from spinal stimulation electrodes. The firing rates of ϳ30% of these neurons were modulated in phase with both the respiratory and cardiac cycles. Furthermore, arterial pulse modulation occurred preferentially in the expiratory phase in that only expiratory neurons had high ␦ 2 values and only expiratory activity had significant ␦ 2 values after partitioning tonic activity into the inspiratory and expiratory phases. The results demonstrate that both respiratory motoneurons and putative premotoneuronal activity can be pulse modulated. We conclude that a cardiac cycle-related modulation is expressed in respiratory motor activity, complementing the long-recognized respiratory modulation of sympathetic nerve activity.control of respiration; homeostasis; laryngeal motoneurons; cardiorespiratory coupling BECAUSE OF THE FUNDAMENTAL physiological and pathophysiological importance of respiration and blood circulation, and the integral functional relationships between these systems, much research has focused on the neural mechanisms involved in coordinating the functions of the cardiovascular and respiratory systems. For example, it has long been recognized that sympathetic activity is modulated with respiration (1). However, although it seems reasonable to anticipate that cardiorespiratory coupling would be reciprocal in nature, presently it is unknown whether the respiratory activity is modulated with cardiovascular function.To determine whether the respiratory control system is modulated in accordance with cardiovascular func...

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Respiratory response to baroreceptor stimulation and spontaneous contractions of the urinary bladder

Cited by 11 publications

References 22 publications

Effect of baroreceptor stimulation on the respiratory pattern: Insights into respiratory–sympathetic interactions

Effect of baroreceptor stimulation on the respiratory pattern: Insights into respiratory–sympathetic interactions

Physiological and pathophysiological interactions between the respiratory central pattern generator and the sympathetic nervous system

Arterial pulse modulated activity is expressed in respiratory neural output

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