Respiratory Syncytial Virus and Human Metapneumovirus in Children With Acute Respiratory Infections in Yemen

Al-Sonboli, Najla; Al-Aeryani, Ahmed; Banajeh, Salem; Al-Aghbari, Nasher; Dove, Winifred; Cuevas, Luís E.

doi:10.1097/01.inf.0000172937.80719.7f

Cited by 44 publications

(37 citation statements)

References 11 publications

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“…The prevalence of coinfection by RSV and hMPV in our study was 3.5%, whereas it was reported to be 4% in a study from Yemen (17). It was also indicated that hMPV and RSV might act in concert to potentiate their pathogenic effects and exacerbate the clinical symptoms of the respiratory disease (32).…”

Section: Discussioncontrasting

confidence: 50%

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The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

Moattari

Aleyasin

Fyruzi

et al. 2015

Arch Pediatr Infect Dis

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Background: Viral infections are the most frequent causes of morbidity and mortality due to respiratory dysfunction worldwide, especially in children under five years of age. Several studies have reported the association of human metapneumovirus (hMPV) and respiratory syncytial virus (RSV) with acute respiratory infection. Objectives: The present study aimed to investigate the prevalence of hMPV, RSV, and their coinfection in children with respiratory symptoms hospitalized in Shiraz City, Fars Province, Iran. The study also attempted to determine the association between asthma and wheezing with hMPV, RSV, and coinfection with both in studied children. Patients and Methods:The study included 280 younger than five years old children with non-influenza infection that were hospitalized for respiratory infection from 2011 to 2013. Nasopharyngeal swabs were collected from patients and tested for RSV and hMPV with reverse transcriptase polymerase chain reaction. Results: The hMPV and RSV were detected in 44 (15.7%) and 84 (30.0%) samples, respectively. Coinfection with both viruses was found in ten patients (3.57%). The incidence of hMPV and RSV infections were observed in children younger than one year old. Infections occurred predominantly from October to April. The most common clinical symptoms were bronchiolitis, wheezing, and cough. Conclusions: Infection with hMPV and RSV are most frequent infections among pediatric patients with respiratory tract symptoms. Coinfection with these viruses may exacerbate the clinical symptoms and increase hospitalization rates, especially in children younger than one year old.

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Section: Discussioncontrasting

confidence: 50%

“…Moreover, hMPV shares an overlapping spectrum with RSV and therefore, they cannot be distinguished by clinical manifestations (13,14). RSV and hMPV might have similar seasonal patterns; hence, their coinfection is possible and must be discriminated by especial laboratory tests (13,(15)(16)(17).…”

Section: Introductionmentioning

confidence: 99%

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

Moattari

Aleyasin

Fyruzi

et al. 2015

Arch Pediatr Infect Dis

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“…This is the first report on the incidence of hMPV-related infections in children in Qatar, though studies have demonstrated the presence of hMPV in the other Middle Eastern countries [32][33][34]. Our data demonstrate a high incidence of the virus in children 6 months to 5 years of age with respiratory tract infections.…”

Section: Resultsmentioning

confidence: 60%

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Althani¹,

Azzam

Abboubaker

et al. 2010

Future Virol.

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Aim: The human metapneumovirus (hMPV) has been recently discovered as an etiological agent of acute respiratory infections in infants and children, with similar clinical symptoms to those caused by respiratory syncytial virus. The aim of this study was to determine the prevalence of hMPV and its potential role as a causative agent of respiratory tract infections in children in Qatar. Methods: In the present study, we examined 84 nasopharyngeal aspirates from children with respiratory tract infections, presenting at Al-Saad Pediatric Emergency Center in Doha, Qatar, as outpatients, for the presence of respiratory viruses. Results: A total of 56 out of 84 (66.7%) cases were positive for the presence of respiratory viruses. Out of the 56 positive cases 54 (96%) contained hMPV; whereas 12 out of 56 (21.4%) contained human parainfluenza virus. A total of 14 out of 56 of the positive patients were infected with more than one virus. hMPV was in samples infected with one or more respiratory tract infection viruses and was the most frequently isolated virus from infants less than 6 months of age. Conclusion: This is the first report demonstrating the prevalence of hMPV in children suffering from respiratory tract infections in Qatar. Detection of this virus may have significant clinical implications in this patient population in Qatar.

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“…Since its first description in 2001 [36], the virus has been further identified in patients with RTIs from all continents [1,3,8,9,14,15,19,21,22,[27][28][29][30][31][32][33][34]41]. Seroprevalence studies in the Netherlands [36], Israel [44] and Japan [11] have shown that by the age of 5 to 10 years, seropositivity reaches virtually 100%.…”

Section: Introductionmentioning

confidence: 99%

Clinical findings and unusual epidemiologic characteristics of human metapneumovirus infections in children in the region of Basel, Switzerland

2007

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Human metapneumovirus (hMPV) worldwide causes respiratory tract infections with features similar to those of RSV infection. We describe features of hMPV infections in children and compare some of the characteristics with those of RSV infections. From October 2004 to February 2006, 75 patients, 34 hospitalized and 41 outpatients, were diagnosed with hMPV infections by multiplex PCR applied to nasopharyngeal specimens. While hMPV was found rarely in the early phase of the study, a significant increase occurred in the second winter of the study period. Patients with hMPV infections were older than those with RSV infection; clinical characteristics were similar as was the rate of serious disease among hospitalized patients (intensive care treatment: 18% versus 8%). In conclusion, hMPV leads to endemic and epidemic respiratory disease with features similar to those of RSV and should be considered in the differential diagnosis of upper and lower respiratory tract disease.

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Respiratory Syncytial Virus and Human Metapneumovirus in Children With Acute Respiratory Infections in Yemen

Cited by 44 publications

References 11 publications

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

The Prevalence of Human Metapneumovirus and Respiratory Syncytial Virus and Coinfection With Both in Hospitalized Children With Acute Respiratory Infection in South of Iran

The Role of Human Metapneumovirus in Pediatric Respiratory Tract Infection in Qatar

Clinical findings and unusual epidemiologic characteristics of human metapneumovirus infections in children in the region of Basel, Switzerland

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