Respiratory toxicity of Fe3O4 nanoparticles: experimental study

Hurbánková, Marta; Volkovová, Katarína; Hraskova, Dominika; Wimmerová, Soňa; Moricova, S.

doi:10.1515/reveh-2016-0022

Cited by 12 publications

(8 citation statements)

References 2 publications

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“…Pulmonary inflammation, which results in changes in membrane permeability, may in turn allow distribution of particles beyond the lung. The NPs have shown significant translocation from the lung into the bloodstream, but also vice versa, as demonstrated in our studies as well as in others (4,6,15).…”

Section: Control Group Mean (Sd) Tio 2 Mean (Sd) Fe 3 O 4 Mean (Sd)supporting

confidence: 90%

“…The activity of CAT-D was measured spectrophotometrically. A detailed description of the mentioned methodology can be found in papers by Hurbankova et al (13)(14)(15) and Dziedzic et al (16).…”

Section: Methodsmentioning

confidence: 99%

“…Examination of the number and the type of the cells obtained via BAL, as well as of their viability and state of activation, enables us to understand the extent of the harmful effects caused to the lung by inhaled noxious substances (15,23). According to Dziedzic et al, long-term recruitment of PMN might be an important factor in prediction of lung metaplastic processes (16).…”

Section: Control Group Mean (Sd) Tio 2 Mean (Sd) Fe 3 O 4 Mean (Sd)mentioning

confidence: 99%

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Comparison of respiratory toxicity of TiO2 and Fe3O4 nanoparticles after intravenous instillation: an experimental study

Hurbánková

Romančíková

Volkovová

et al. 2020

Cent Eur J Public Health

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Objective: Nanomaterials consist of particles smaller than 100 nm -nanoparticles (NPs). Their nano dimensions allow them to penetrate through various membranes and enter into the bloodstream and disseminate into different body organs. Massive expansion of nanotechnologies together with production of new nanoparticles which have not yet been in contact with living organisms may pose a potential health problem. It is therefore necessary to investigate the health impact of NPs after experimental exposure. Comparison of the effect of TiO 2 and NPs Fe 3 O 4 in Wistar rats at time intervals 1, 7, 14 and 28 days was performed by studying the cytotoxic effect in the isolated inflammatory cells from bronchoalveolar lavage (BAL).Methods: Wistar rats were intravenously (i.v.) given a suspension of NPs TiO 2 or Fe 3 O 4 (coated by sodium oleate) via the tail vein. After time intervals of 1, 7, 14 and 28 days, we sacrificed the animals under anaesthesia, performed BAL and isolated the cells. The number of animals in the individual groups was 7-8. We examined the differential count of BAL cells (alveolar macrophages -AM, polymorphonuclear leukocytes -PMN, lymphocytes -Ly); viability and phagocytic activity of AM; the proportion of immature and polynuclear cells and enzymes -cathepsin D -CAT D, lactate dehydrogenase -LDH and acid phosphatase -ACP.Results: We found that TiO 2 NPs are relatively inert -without induction of inflammatory and cytotoxic response. Exposure to nanoparticles Fe 3 O 4 induced -under the same experimental conditions -in comparison with the control and TiO 2 a more extensive inflammatory and cytotoxic response, albeit only at 1, 7 and 14 days after injection.Conclusions: The results suggest that TiO 2 and Fe 3 O 4 nanoparticles used in our study were transferred from the bloodstream to the respiratory tract, but this effect was not observed at 28 days after i.v. injection, probably due to their removal from the respiratory tract.

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Section: Control Group Mean (Sd) Tio 2 Mean (Sd) Fe 3 O 4 Mean (Sd)supporting

confidence: 90%

Section: Methodsmentioning

confidence: 99%

Section: Control Group Mean (Sd) Tio 2 Mean (Sd) Fe 3 O 4 Mean (Sd)mentioning

confidence: 99%

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Comparison of respiratory toxicity of TiO2 and Fe3O4 nanoparticles after intravenous instillation: an experimental study

Hurbánková

Romančíková

Volkovová

et al. 2020

Cent Eur J Public Health

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“…In many cases, the cellular constituents obtained in the lavage provide a good indication of lung injury. Examination of the amount and the type of cells obtained via BAL, as well as their viability and activity, helps to understand the extent of the harmful effects in lungs caused by inhaled noxious substances (20,24,25). According to Dziedzic et al long-term recruitment of PMNL might be an important factor in prediction of lung metaplastic processes (20).…”

Section: Discussionmentioning

confidence: 99%

Respiratory toxicity of TiO2 nanoparticles after intravenous instillation: an experimental study

Hurbánková

Volkovová

Wimmerová

et al. 2018

Cent Eur J Public Health

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Objective: Nanomaterials are materials consisting of particles having one or more dimensions smaller than 100 nm. Nanoparticles (NP) have different properties and effects in comparison with the same particle materials of larger size. They can penetrate through various membranes and get from the bloodstream to other organs in the body. Therefore, in our experiment we have dealt with the impact of nanoparticles TiO 2 instilled intravenously (i.v.) (to a tail vein of an animal) on the selected parameters of bronchoalveolar lavage (BAL). The aim of our study was to determine whether TiO 2 nanoparticles do pass through the vascular system to the respiratory tract, and if so, how they affect the selected inflammatory and cytotoxic parameters of bronchoalveolar lavage. Methods: Wistar rats were intravenously given a suspension of TiO 2 nanoparticles in saline solution. This suspension contained 10% volume of rat serum in dose: 1.0% from LD50 = 0.592 mg/kg of animal body weight. After the time intervals 1, 7, 14 and 28 days, the animals were sacrificed under anaesthesia; bronchoalveolar lavage was performed and the BAL cells were isolated. We have examined these markers: differential count of BAL cells-alveolar macrophages (AM), polymorphonuclear leukocytes (PMNL), lymphocytes (Ly); viability and phagocytic activity of AM; proportion of immature cells and cathepsin D enzyme levels. Results: Regarding the respiratory toxicity of TiO 2 nanoparticles we have found that TiO 2 nanoparticles are relatively inert. BAL examined parameters (except the immature form of AM) were not significantly changed after 28 days of instillation compared to the control group. We found that the TiO 2 nanoparticles used in our study were transferred from the bloodstream to the respiratory tract, but in a 28-day phase after i.v. instillation have been largely eliminated by the defence mechanism from the respiratory tract. Conclusions: We suggest low biopersistence and relatively rapid elimination of TiO 2 nanoparticles from the lung under used experimental conditions.

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“…Hilger at al. [62] injected supermagnetic NPs into immunodeficient mice with implanted breast adenocarcinoma cells and after applying a magnetic field with 400 kHz frequency, the temperature within the tumor region rose to 73 • C. Based on the general presumption for penetration of NPs through various membranes, Hurbankova et al [63] studied the impact of Fe 3 O 4 NPs on the vascular system of the respiratory tract together with the inflammatory and cytotoxic parameters of bronchoalveolar lavage. The iron oxide NPs, compared to the control, induce an inflammatory response, cytotoxic damage and respiratory toxicity.…”

Section: Iron Oxide Nanoparticlesmentioning

confidence: 99%

Metal Oxide Nanoparticles as Biomedical Materials

Nikolova

Chavali²

2020

Biomimetics

343

146

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The development of new nanomaterials with high biomedical performance and low toxicity is essential to obtain more efficient therapy and precise diagnostic tools and devices. Recently, scientists often face issues of balancing between positive therapeutic effects of metal oxide nanoparticles and their toxic side effects. In this review, considering metal oxide nanoparticles as important technological and biomedical materials, the authors provide a comprehensive review of researches on metal oxide nanoparticles, their nanoscale physicochemical properties, defining specific applications in the various fields of nanomedicine. Authors discuss the recent development of metal oxide nanoparticles that were employed as biomedical materials in tissue therapy, immunotherapy, diagnosis, dentistry, regenerative medicine, wound healing and biosensing platforms. Besides, their antimicrobial, antifungal, antiviral properties along with biotoxicology were debated in detail. The significant breakthroughs in the field of nanobiomedicine have emerged in areas and numbers predicting tremendous application potential and enormous market value for metal oxide nanoparticles.

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Respiratory toxicity of Fe3O4 nanoparticles: experimental study

Cited by 12 publications

References 2 publications

Comparison of respiratory toxicity of TiO<sub>2</sub> and Fe<sub>3</sub>O<sub>4</sub> nanoparticles after intravenous instillation: an experimental study

Comparison of respiratory toxicity of TiO<sub>2</sub> and Fe<sub>3</sub>O<sub>4</sub> nanoparticles after intravenous instillation: an experimental study

Respiratory toxicity of TiO<sub>2</sub> nanoparticles after intravenous instillation: an experimental study

Metal Oxide Nanoparticles as Biomedical Materials

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