Respiratory Virus Vaccines

Broadbent, Andrew; Boonnak, Kobporn; Subbarao, Kanta

doi:10.1016/b978-0-12-415847-4.00059-8

Cited by 11 publications

(8 citation statements)

References 438 publications

(496 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…A serum HAI titer of 1:40 is an accepted correlate of protection for IIV [13]. However, seroconversion rates and titers of serum antibody following LAIV are lower than after IIV [14][15][16]. Furthermore, LAIV has been shown to be effective in the absence of a robust serum HAI antibody response, indicating that serum HAI antibody is not an accurate correlate of protection for this vaccine [17].…”

Section: Lessons From Seasonal Laivmentioning

confidence: 99%

How Live Attenuated Vaccines Can Inform the Development of Broadly Cross-Protective Influenza Vaccines

Rudraraju

Mordant

Subbarao

2019

The Journal of Infectious Diseases

Self Cite

View full text Add to dashboard Cite

Section: Lessons From Seasonal Laivmentioning

confidence: 99%

How Live Attenuated Vaccines Can Inform the Development of Broadly Cross-Protective Influenza Vaccines

Rudraraju

Mordant

Subbarao

2019

The Journal of Infectious Diseases

Self Cite

View full text Add to dashboard Cite

“…As respiratory viral infections are usually confined to the lung and only spread systemically in some of the most severe cases, control of infection mostly relies on lung resident immune mechanisms [1]. However, many viral pathogens successfully evade the induction of durable and effective memory responses in the lung after natural infection or vaccination and are therefore able to cause multiple infections throughout a person's lifetime [2][3][4]. Complementary to antibodies, lung tissue resident memory T cells (T RM ) are increasingly appreciated as a key component of protective responses in the lung [5].…”

Section: Introductionmentioning

confidence: 99%

Type I interferons and MAVS signaling are necessary for tissue resident memory CD8+ T cell responses to RSV infection

et al. 2022

View full text Add to dashboard Cite

Respiratory syncytial virus (RSV) can cause bronchiolitis and viral pneumonia in young children and the elderly. Lack of vaccines and recurrence of RSV infection indicate the difficulty in eliciting protective memory immune responses. Tissue resident memory T cells (TRM) can confer protection from pathogen re-infection and, in human experimental RSV infection, the presence of lung CD8+ TRM cells correlates with a better outcome. However, the requirements for generating and maintaining lung TRM cells during RSV infection are not fully understood. Here, we use mouse models to assess the impact of innate immune response determinants in the generation and subsequent expansion of the TRM cell pool during RSV infection. We show that CD8+ TRM cells expand independently from systemic CD8+ T cells after RSV re-infection. Re-infected MAVS and MyD88/TRIF deficient mice, lacking key components involved in innate immune recognition of RSV and induction of type I interferons (IFN-α/β), display impaired expansion of CD8+ TRM cells and reduction in antigen specific production of granzyme B and IFN-γ. IFN-α treatment of MAVS deficient mice during primary RSV infection restored TRM cell expansion upon re-challenge but failed to recover TRM cell functionality. Our data reveal how innate immunity, including the axis controlling type I IFN induction, instructs and regulates CD8+ TRM cell responses to RSV infection, suggesting possible mechanisms for therapeutic intervention.

show abstract

“…The review has discussed the viral respiratory infection mechanism, epidemiology, pathogenesis, disease symptoms, and related drugs and vaccines. The analysis suggested that viruses of six different virus families target the respiratory tract (Additional file 1: Table S1) [6][7][8][9][10]. The genome of the majority of these viruses is single stranded RNA.…”

Section: Discussionmentioning

confidence: 99%

“…There are 12 different viruses belonging to different virus families that cause infections in the respiratory system (Fig. 1; Additional file 1: Table S1) [6][7][8][9][10]. At least one virus from each of the virus family of the Baltimore virus classification represents respiratory infections (Fig.…”

Section: Introductionmentioning

confidence: 99%

Respiratory illness virus infections with special emphasis on COVID-19

et al. 2022

View full text Add to dashboard Cite

Viruses that emerge pose challenges for treatment options as their uniqueness would not know completely. Hence, many viruses are causing high morbidity and mortality for a long time. Despite large diversity, viruses share common characteristics for infection. At least 12 different respiratory-borne viruses are reported belonging to various virus taxonomic families. Many of these viruses multiply and cause damage to the upper and lower respiratory tracts. The description of these viruses in comparison with each other concerning their epidemiology, molecular characteristics, disease manifestations, diagnosis and treatment is lacking. Such information helps diagnose, differentiate, and formulate the control measures faster. The leading cause of acute illness worldwide is acute respiratory infections (ARIs) and are responsible for nearly 4 million deaths every year, mostly in young children and infants. Lower respiratory tract infections are the fourth most common cause of death globally, after non-infectious chronic conditions. This review aims to present the characteristics of different viruses causing respiratory infections, highlighting the uniqueness of SARS-CoV-2. We expect this review to help understand the similarities and differences among the closely related viruses causing respiratory infections and formulate specific preventive or control measures.

show abstract

Respiratory Virus Vaccines

Cited by 11 publications

References 438 publications

How Live Attenuated Vaccines Can Inform the Development of Broadly Cross-Protective Influenza Vaccines

How Live Attenuated Vaccines Can Inform the Development of Broadly Cross-Protective Influenza Vaccines

Type I interferons and MAVS signaling are necessary for tissue resident memory CD8+ T cell responses to RSV infection

Respiratory illness virus infections with special emphasis on COVID-19

Contact Info

Product

Resources

About