Respiratory viruses are associated with serum metabolome among infants hospitalized for bronchiolitis: A multicenter study

Abstract

Background: Bronchiolitis is the leading cause of infant hospitalizations in the United States. Growing evidence supports the heterogeneity of bronchiolitis. However, little is known about the interrelationships between major respiratory viruses (and their species), host systemic metabolism, and disease pathobiology. Methods: In an ongoing multicenter prospective cohort study, we profiled the serum metabolome in 113 infants (63 RSV-only, 21 RV-A, and 29 RV-C) hospitalized with bronchiolitis. We identified serum metabolites that are most discriminatory in the RSV-RV-A and RSV-RV-C comparisons using sparse partial least squares discriminant analysis. We then investigated the association between discriminatory metabolites with acute and chronic outcomes. Results: In 113 infants with bronchiolitis, we measured 639 metabolites. Serum metabolomic profiles differed in both comparisons (P permutation < 0.05). In the RSV-RV-A comparison, we identified 30 discriminatory metabolites, predominantly in lipid metabolism pathways (eg, sphingolipids and carnitines). In multivariable models, these metabolites were significantly associated with the risk of clinical outcomes (eg, tricosanoyl sphingomyelin, OR for recurrent wheezing at age of 3 years = 1.50; 95% CI: 1.05-2.15). In the RSV-RV-C comparison, the discriminatory metabolites were also primarily involved in lipid metabolism (eg, glycerophosphocholines [GPCs], 12,13-diHome). These metabolites were also significantly associated with the risk of outcomes (eg, 1-stearoyl-2-linoleoyl-GPC, OR for positive pressure ventilation use during hospitalization = 0.47; 95% CI: 0.28-0.78). Conclusion: Respiratory viruses and their species had distinct serum metabolomic signatures that are associated with differential risks of acute and chronic morbidities of bronchiolitis. Our findings advance research into the complex interrelations between viruses, host systemic response, and bronchiolitis pathobiology.

Plasma Metabolomic Profiles in Recovered COVID-19 Patients without Previous Underlying Diseases 3 Months After Discharge

“…Metabolic changes in plasma have been previously reported for different viral infections, such as SARS, 6 H1N1, 7 respiratory syncytial virus, 8 Ebola virus 9 and dengue. 10 Recent studies have revealed that metabolic dysregulation in COVID-19 patients and metabolites may help stratify patients in terms of disease severity during hospitalisation.…”

Integrated associations of nasopharyngeal and serum metabolome with bronchiolitis severity and asthma: A multicenter prospective cohort study

“…However, in agreement with the current study, the emerging evidence on bronchiolitis suggests the complexity in the disease pathobiology, reflected by heterogeneous host transcriptome, 11,12 microRNA, 11 cytokine, 13 and upper airway microbiome 10,33 profiles among infants with bronchiolitis. Additionally, recent studies have individually applied a metabolomic approach to each of the upper airway 14,34 and serum 15,35 sample, and reported between‐virus (and viral species) differences in the metabolic pathways in infants with bronchiolitis. Interestingly, these studies have shown that the discriminatory metabolites differ between the airway and circulating systems; however, their integrated relationship remained uncertain.…”

Plasma Metabolomic Profiles and Clinical Features in Recovered COVID-19 Patients Without Previous Underlying Diseases 3 Months After Discharge

“…This was especially true of the severe and critical COVID-19 patients. 8,9,32 Therefore, we hypothesize that these metabolic disruptions in the recovered COVID-19 patients might also result from damages caused by COVID-19 viruses. The elevation of bile acid derivatives, such as chenodeoxycholic acid (CDCA), glycochenodeoxycholate-3-sulfate (GCDCS) in the plasma of recovered patients, compared with HC, may indicate hepatic detoxi cation function was impaired and biliary ducts were injured.…”

“…Small molecular metabolites, as the downstream products of genes and proteins, are closely related to the phenotype, and can accurately re ect subtle changes and potential impact under the biological state. 5 Metabolic changes in plasma have been previously reported for different viral infections, such as infection with SARS, 6 H1N1, 7 respiratory syncytial virus, 8 Ebola virus 9 and dengue. 10 Recent studies revealed metabolic dysregulation in COVID-19 patients and metabolites may help stratify patients in term of disease severity during hospitalization.…”