Response characterization of an Y2O3:Eu-based radioluminescence probe under 60Co irradiation

Molina, P.; Sommer, M.; Kattner, F.; Henniger, J.

doi:10.1016/j.radmeas.2013.01.031

Cited by 17 publications

(14 citation statements)

References 21 publications

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“…Measurements by Molina et al (2013), Pittet et al (2013) and Martinez et al (2015) show that the sensitivity to low-energy radiation is higher for ISDs with high Z eff than for ionization chambers. Their measurements demonstrate that the ISD response increases with respect to that of the ion chamber as the lower energy secondary radiation component becomes more dominant compared with the higher energy primary radiation, which results in overestimated absorbed doses to water.…”

Section: Introductionmentioning

confidence: 97%

“…These Eu-activated scintillators have been studied for use with various external-beam radiation sources (Martinez et al 2015, Molina et al 2013, 2012, Souris et al 2014, McCarthy et al 2014), but their suitability for use with 192 Ir BT sources has yet to be established. Investigators have studied detectors using nanometer-sized Y 2 O 3 crystals co-doped with Eu and Li (Stanton et al 2014) for external-beam sources (Belley et al 2015b) and for 192 Ir HDR BT (Belley et al 2015a).…”

Section: Introductionmentioning

confidence: 99%

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Inorganic scintillation detectors based on Eu-activated phosphors for¹⁹²Ir brachytherapy

Kertzscher

Beddar

2017

Phys. Med. Biol.

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The availability of real-time treatment verification during high-dose-rate (HDR) brachytherapy is currently limited. Therefore, we studied the luminescence properties of the widely commercially available scintillators using the inorganic materials Eu-activated phosphors Y2O3:Eu, YVO4:Eu, Y2O2S:Eu, and Gd2O2S:Eu to determine whether they could be used to accurately and precisely verify HDR brachytherapy doses in real time. The suitability for HDR brachytherapy of inorganic scintillation detectors (ISDs) based on the 4 Eu-activated phosphors in powder form was determined based on experiments with a 192Ir HDR brachytherapy source. The scintillation intensities of the phosphors were 16 to 134 times greater than that of the commonly used organic plastic scintillator BCF-12. High signal intensities were achieved with an optimized packing density of the phosphor mixture and with a shortened fiber-optic cable. The influence of contaminating Cerenkov and fluorescence light induced in the fiber-optic cable (stem signal) was adequately suppressed by inserting between the fiber-optic cable and the photodetector a 25-nm band-pass filter centered at the emission peak. The spurious photoluminescence signal induced by the stem signal was suppressed by placing a long-pass filter between the scintillation detector volume and the fiber-optic cable. The time-dependent luminescence properties of the phosphors were quantified by measuring the non-constant scintillation during irradiation and the afterglow after the brachytherapy source had retracted. We demonstrated that a mixture of Y2O3:Eu and YVO4:Eu suppressed the time-dependence of the ISDs and that the time-dependence of Y2O2S:Eu and Gd2O2S:Eu introduced large measurement inaccuracies. We conclude that ISDs based on a mixture of Y2O3:Eu and YVO4:Eu are promising candidates for accurate and precise real-time verification technology for HDR BT that is cost effective and straightforward to manufacture. Widespread dissemination of this technology could lead to an improved understanding of error types and frequencies during BT and to improved patient safety during treatment.

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Section: Introductionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Inorganic scintillation detectors based on Eu-activated phosphors for¹⁹²Ir brachytherapy

Kertzscher

Beddar

2017

Phys. Med. Biol.

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“…Yttrium phosphors doped with Eu such as Y 2 O 3 :Eu, Y 2 O 2 S:Eu, and YVO 4 :Eu emit bright red-light under UV or X-ray excitation; these have been used widely in the industry (e.g., white LEDs). Attempts have also been made to utilize them for dosimetry [57][58][59][60]. One merit of these Eu-doped yttrium phosphors is that they provide the convenience of the stem effect removal with the simplest optical-filtering method.…”

Section: Iosfd For X-ray Rtdmentioning

confidence: 99%

“…All three materials showed no changes in RL response as dose accumulates with no afterglow decay. The same research group further studied the feasibility of using Y 2 O 3 :Eu-based IOSFD for real-time dosimetry under 60 Co irradiation [58]. The stem effect signal was successfully suppressed via a long-pass optical filter (610 nm).…”

Section: Iosfd For X-ray Rtdmentioning

confidence: 99%

Advances on inorganic scintillator-based optic fiber dosimeters

Ding

Wang³

et al. 2020

EJNMMI Phys

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This article presents a new perspective on the development of inorganic scintillator-based fiber dosimeters (IOSFDs) for medical radiotherapy dosimetry (RTD) focusing on real-time in vivo dosimetry. The scintillator-based optical fiber dosimeters (SFD) are compact, free of electromagnetic interference, radiation-resistant, and robust. They have shown great potential for real-time in vivo RTD. Compared with organic scintillators (OSs), inorganic scintillators (IOSs) have larger X-ray absorption and higher light output. Variable IOSs with maximum emission peaks in the red part of the spectrum offer convenient stem effect removal. This article outlines the main advantages and disadvantages of utilizing IOSs for SFD fabrication. IOSFDs with different configurations are presented, and their use for dosimetry in X-ray RT, brachytherapy (BT), proton therapy (PT), and boron neutron capture therapy (BNCT) is reviewed. Challenges including the percentage depth dose (PDD) deviation from the standard ion chamber (IC) measurement, the angular dependence, and the Cherenkov effect are discussed in detail; methods to overcome these problems are also presented.

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“…However, materials with high Z eff have been reported to be sensitive to low-energy radiation. [38][39][40] Therefore, in the case of BaFBr:Eu 2+ , it is necessary to pay attention to energy dependence. In SBRT, the field size does not change significantly with the delivery beam, so it is necessary to evaluate the difference in response to water with respect to the depth from the body surface.…”

Section: C5 Effects Of Energy Dependence During Sbrt Deliverymentioning

confidence: 99%

Real‐time in vivo dosimetry system based on an optical fiber‐coupled microsized photostimulable phosphor for stereotactic body radiation therapy

et al. 2020

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Purpose: To develop an in vivo dosimeter system for stereotactic body radiation therapy (SBRT) that can perform accurate and precise real-time measurements, using a microsized amount of a photostimulable phosphor (PSP), BaFBr:Eu 2+. Methods: The sensitive volume of the PSP was 1.26 9 10 À5 cm 3. The dosimeter system was designed to apply photostimulation to the PSP after the decay of noise signals, in synchronization with the photon beam pulse of a linear accelerator (LINAC), to eliminate the noise signals completely using a time separation technique. The noise signals included stem signals, and radioluminescence signals generated by the PSP. In addition, the dosimeter system was built on a storage-type dosimeter that could read out a signal after an arbitrary preset number of photon beam pulses were incident. First, the noise and photostimulated luminescence (PSL) signal decay times were measured. Subsequently, we confirmed that the PSL signals could be exclusively read out within the photon beam pulse interval. Finally, using a water phantom, the basic characteristics of the dosimeter system were demonstrated under SBRT conditions, and the feasibility for clinical application was investigated. The reproducibility, dose linearity, dose-rate dependence, temperature dependence, and angular dependence were evaluated. The feasibility was confirmed by measurements at various dose gradients and using a representative treatment plan for a metastatic liver tumor. A clinical plan was created with a two-arc beam volumetric modulated arc therapy using a 10 MV flattening filter-free photon beam. For the water phantom measurements, the clinical plan was compiled into a plan with a fixed gantry angle of 0°. To evaluate the energy dependence during SBRT, the percent depth dose (PDD) was measured and compared with those calculated via Monte Carlo (MC) simulations. Results: All the PSL signals could be read out while eliminating the noise signals within the minimum pulse interval of the LINAC. Stable real-time measurements could be performed with a time resolution of 56 ms (i.e., number of pulses = 20). The dose linearity was good in the dose range of 0.01-100 Gy. The measurements agreed within 1% at dose rates of 40-2400 cGy/min. The temperature and angular dependence were also acceptable since these dependencies had only a negligible effect on the measurements in SBRT. At a dose gradient of 2.21 Gy/mm, the measured dose agreed with that calculated using a treatment planning system (TPS) within the measurement uncertainties due to the probe position. For measurements using a representative treatment plan, the measured dose

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Response characterization of an Y2O3:Eu-based radioluminescence probe under 60Co irradiation

Cited by 17 publications

References 21 publications

Inorganic scintillation detectors based on Eu-activated phosphors for¹⁹²Ir brachytherapy

Inorganic scintillation detectors based on Eu-activated phosphors for¹⁹²Ir brachytherapy

Advances on inorganic scintillator-based optic fiber dosimeters

Real‐time in vivo dosimetry system based on an optical fiber‐coupled microsized photostimulable phosphor for stereotactic body radiation therapy

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Response characterization of an Y2O3:Eu-based radioluminescence probe under 60Co irradiation

Cited by 17 publications

References 21 publications

Inorganic scintillation detectors based on Eu-activated phosphors for192Ir brachytherapy

Inorganic scintillation detectors based on Eu-activated phosphors for192Ir brachytherapy

Advances on inorganic scintillator-based optic fiber dosimeters

Real‐time in vivo dosimetry system based on an optical fiber‐coupled microsized photostimulable phosphor for stereotactic body radiation therapy

Contact Info

Product

Resources

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Inorganic scintillation detectors based on Eu-activated phosphors for¹⁹²Ir brachytherapy

Inorganic scintillation detectors based on Eu-activated phosphors for¹⁹²Ir brachytherapy