Response Evaluation Criteria in Solid Tumors (RECIST) Criteria Are Superior to European Association for Study of the Liver (EASL) Criteria at 1 Month Follow-up for Predicting Long-term Survival in Patients Treated with Transarterial Chemoembolization before Liver Transplantation for Hepatocellular Cancer

The mRECIST Classification Provides Insight into Tumor Biology for Patients With Hepatocellular Carcinoma Awaiting Liver Transplantation

“…Three groups have chosen the first mRECIST assessment following the first LRT at listing. (9,(20)(21)(22) We found this to be problematic because most studies have demonstrated that LRT is rarely curative and most patients developed some degree of progression as is evidenced by the high number of patients in our study who had greater than 1 LRT. This number is only likely to increase as waiting times extend for patients with HCC.…”

“…The role of mRECIST has been studied multiple different ways. Three groups have chosen the first mRECIST assessment following the first LRT at listing . We found this to be problematic because most studies have demonstrated that LRT is rarely curative and most patients developed some degree of progression as is evidenced by the high number of patients in our study who had greater than 1 LRT.…”

Can response to locoregional therapy help predict longterm survival after liver transplantation for hepatocellular carcinoma? A systematic review

“…Two published manuscripts demonstrated an improvement in 5‐year OS but not RFS. Millonig et al and Shuster et al both report that patients who had CR or PR had significantly longer OS compared with SD or PD (CR = 85.1% versus SD+PD = 51.4%, P = 0.02; CR+PR = 89.9% versus SD+PD = 34.3%, P = 0.02, respectively). Millonig et al also did an ITT analysis on all patients listed for transplant who received LRT.…”

Multimodal treatment of unresectable hepatocellular carcinoma to achieve complete response results in improved survival

“…Patients that had a complete response to transarterial treatment as their best treatment had a significantly longer overall median survival compared with those that had a partial response, and with those who had stable disease. Multiple studies have shown that improved survival in HCC is associated with a response to transarterial treatment based on modified RECIST . However, as outlined by Anderson et al ., these papers suffer from a bias introduced by dividing patients based on response and then statistically comparing their survival.…”

“…The Kaplan–Meier method was used to display overall survival by best response and to calculate the median survival times and confidence intervals (CI) for each response. However, making statistical inference of survival by treatments from comparison of survival by response has been criticized because ‘response’ could be a marker for patients with a favourable prognosis . Therefore, multivariate Cox Regression analysis was used to assess whether response predicted survival independently of patient baseline characteristics, with a response as a time‐dependent covariate.…”