“…This suggests that expectation-induced mechanisms, which are more effective in highs than in lows , are associated with those sustaining the conditioned analgesia. However, in highs the expectation of pain relief does not totally account for the suggestion induced analgesia (Gearan and Kirsch, 1993 ) and it is unlikely that the expectation of analgesia could be sustained by opioid mechanisms, in contrast to the general population (Amanzio and Benedetti, 1999 ; Benedetti et al, 1999 ; Petrovic et al, 2002 ; Zubieta et al, 2005 ; Scott et al, 2008 ; Babel et al, 2017 ). In fact, not only the effects of suggestions is not abolished by naloxone (Moret et al, 1991 ) but, in addition, highs display the μ1 polymorphism (Presciuttini et al, 2018 ) which has been found associated with low sensitivity to opiates, low placebo response (Trescot and Faynboym, 2014 ; Bartošová et al, 2015 ; Peciña and Zubieta, 2015 ) and larger opiates consumption for post-surgery (Zhang et al, 2005 ; Boswell et al, 2013 ; Sia et al, 2013 ; Ren et al, 2015 ) and cancer pain (Gong et al, 2013 ; Wan et al, 2015 ; Yao et al, 2015 ).…”