The prediction of the laminar-turbulent transition of boundary layers is critically important to the development of hypersonic vehicles because the transition has a first-order impact on aerodynamic heating, drag, and vehicle operation. The success of transition prediction relies on a fundamental understanding of the relevant physical mechanisms. In the 20 years since the review by Kleiser & Zang (1991) on the direct numerical simulation (DNS) of the boundary-layer transition, significant progress has been made on DNS in the hypersonic flow regime and in the spatial DNS approach. Many high-order shock-capturing and shock-fitting finite-difference methods have been developed and extensively applied to numerical simulations of the hypersonic boundary-layer transition. DNS has become a powerful research tool and has led to discoveries of new transition mechanisms. This article reviews the recent progress of DNS on hypersonic boundary-layer receptivity, instability, and transition. The current status and future directions are also presented. 527 Annu. Rev. Fluid Mech. 2012.44:527-561. Downloaded from www.annualreviews.org by University of California -Los Angeles (Young Research Library) on 01/04/12. For personal use only. Receptivity mechanisms Transient growth B Increasing disturbance level Figure 1Paths to boundary-layer transition with respect to the disturbance amplitude. Path A, three-stage-transition mechanism in a weak-disturbance environment; path B, three-stage-transition mechanism including weak transient growth; paths C and D, transition mechanisms with strong transient growth; path E, bypass transition to very strong disturbance. Figure taken from Reshotko (