The study of periodic systems under the action of moving loads is of high practical importance in railway, road, and bridge engineering, among others. Even though plenty of studies focus on periodic systems, few of them are dedicated to the influence of a local inhomogeneous region, a so-called transition zone, on the dynamic response. In railway engineering, these transition zones are prone to significant degradation, leading to more maintenance requirements than the rest of the structure. This study aims to identify and investigate phenomena that arise due to the combination of periodicity and local inhomogeneity in a system acted upon by a moving load. To study such phenomena in their purest form, a one-dimensional model is formulated consisting of a constant moving load acting on an infinite string periodically supported by discrete springs and dashpots, with a finite domain in which the stiffness and damping of the supports is larger than for the rest of the infinite domain; this model is representative of a catenary system (overhead wires in railway tracks). The identified phenomena can be considered as additional constraints for the design parameters at transition zones such that dynamic amplifications are avoided.