Response of Bali cattle (Bos javanicus) to vaccination with Brucella abortus strain 19 in West Timor

Geong, Maria; Robertson, Ian D.

doi:10.1016/s0167-5877(00)00174-4

Cited by 6 publications

(4 citation statements)

References 10 publications

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“…Calves and non-pregnant replacement heifers (up to 15 months of age) were inoculated with 6 × 10 10 -12 × 10 10 colony forming units-CFU (a standard dose of A19), and the adults (≥ 2 years of age) or pregnant replacement heifers with a reduced dose of A19 (6 × 10 8 -12 × 10 8 CFU, 1/100 dilution). The rationale of this reduced dose is to minimise vaccine side effects, referring to studies reporting that a reduced dose of immunisation of adult and pregnant heifers does not induce abortion (Chand et al 2015;Geong and Robertson 2000). A19 and S19 are highly homologous strains, but no studies have reported the safety and efficacy of a reduced dose of A19 in pregnant cows.…”

Section: Emergency Vaccination Of Animalsmentioning

confidence: 99%

“…A19 and S19 are highly homologous strains, but no studies have reported the safety and efficacy of a reduced dose of A19 in pregnant cows. Therefore, this study used a 100-fold reduced dose of A19 to immunize pregnant adults and heifers, as was done in the S19 studies (Chand et al 2015;Geong and Robertson 2000). The vaccine was inoculated subcutaneously behind the shoulder.…”

Section: Emergency Vaccination Of Animalsmentioning

confidence: 99%

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A case study investigating the effects of emergency vaccination with Brucella abortus A19 vaccine on a dairy farm undergoing an abortion outbreak in China

Wang

Peng

et al. 2022

Animal Diseases

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Brucellosis is an important zoonosis that results in substantial economic losses to the livestock industry through abortions and reduced milk yield. This study investigated an abortion outbreak in a dairy herd and then explored the effects of emergency vaccination with Brucella abortus A19 vaccine on the incidence of abortion and milk yield. A full dose of vaccine (6 × 1010—12 × 1010 colony forming units, CFU) was administered subcutaneously to calves and non-pregnant heifers, and a reduced dose (6 × 108—12 × 108 CFU) to adult cows and pregnant replacement heifers. Rose Bengal Test was used to screen Brucella infection status and then positive samples were tested with a C-ELISA. Animals that tested positive for both tests were considered positive to Brucella spp. The animal-level seroprevalence of brucellosis was 23.1% (95% CI: 17.0, 30.2), and the attributable fraction of abortions in seropositive animals was 89.1% (95% CI: 64.3, 96.7). The odds of seropositivity were significantly higher in cows that aborted compared to cows that calved normally (OR = 21.4, 95% CI: 4.4, 168.4). Cows in sheds A2 and C1 were 10.2 (95% CI: 1.4, 128.0) and 17.0 (95% CI: 2.8, 190.3) times more likely to be seropositive than cows in shed B1. Antibodies were not detectable in most heifers 12 months post-vaccination. The effectiveness of the vaccine in preventing abortions was estimated to be 56.8% (95% CI: 15.8, 77.8) for the entire herd, but increased to 86.7% (95% CI: 4.4, 98.1) when only primiparous heifers were considered. Furthermore, a significant increase in the average herd 305-day milk yield one-year after vaccination was also observed relative to that in the previous three years. It is concluded that emergency vaccination of a dairy herd undergoing an abortion outbreak with the A19 vaccine effectively reduced the incidence of abortion and indirectly increased milk yield one-year after vaccination.

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Section: Emergency Vaccination Of Animalsmentioning

confidence: 99%

Section: Emergency Vaccination Of Animalsmentioning

confidence: 99%

A case study investigating the effects of emergency vaccination with Brucella abortus A19 vaccine on a dairy farm undergoing an abortion outbreak in China

Wang

Peng

et al. 2022

Animal Diseases

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“…In Indonesia, brucellosis was isolated from cattle in Java as early as 1915 [9]. Subsequent serological studies have indicated the presence of bovine brucellosis in cattle in different islands of the Indonesian archipelago including South Sulawesi and West Timor [10,11]. Porcine brucellosis has been reported in pigs in Java with a seroprevalence in the Rose Bengal test (RBT) of 22.3% for pigs slaughtered in Kapuk Jakarta in West Java and of 14.9% for animals tested at a slaughterhouse in Surabaya in East Java [12].…”

Section: Introductionmentioning

confidence: 99%

Brucellosis seroprevalence in Bali cattle with reproductive failure in South Sulawesi and Brucella abortus biovar 1 genotypes in the Eastern Indonesian archipelago

Muflihanah¹,

Hatta

Rood

et al. 2013

BMC Vet Res

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BackgroundBrucellosis is a major cause of infertility and reproductive failure in livestock. While cattle in the Eastern Indonesian archipelago suffers from reproductive problems information on bovine brucellosis in the region is fragmentary. The control of brucellosis requires a major and prolonged effort and confirmation of the infection by isolation with detailed knowledge of the spread of the infection is essential when planning a control program.ResultsSerological investigation of Brucella infection in beef cattle tended under extensive farming conditions revealed a high seroprevalence (19.3%; 95% CI, 17–22) in the compliment fixation tests. The results of a rapid and simple field test correlated well with the Rose Bengal test (kappa, 0.917) and indicated an acceptable sensitivity (87.5%) and specificity (98.1%) compared with the complement fixation test. Reproductive failure was reported for 39.0% of the cows with a loss of calves due to abortion or early death amounting to 19.3%. Past reproductive failure did not, however, correlate with seropositivity in the complement fixation test (RP = 1.21; P = 0.847). B. abortus biovar 1 was freshly isolated from the hygromas of two cows and together with thirty banked isolates collected since 1990 from different parts of Sulawesi and Timor eight related genotypes could be distinguished with one genotype being identical to that of an isolate (BfR91) from Switzerland. The Indonesian genotypes formed together with BfR91 and one African and one North American isolate a distinct branch on the B. abortus biovar 1 dendogram.ConclusionsBovine brucellosis appears to be widespread in the Eastern Indonesian archipelago and calls for urgent intervention. The fresh isolation of the pathogen together with the observed high seroprevalence demonstrates the presence and frequent exposure of cattle in the area to the pathogen. The application of a rapid and simple field test for brucellosis could be very useful for the quick screening of cattle at the pen side.

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“…No entanto, este tipo de vacinação pode levar a títulos de anticorpos persistentes, infecções induzidas pela cepa B19 e abortamentos (SANGARI et al, 1996;GEONG;ROBERTSON, 2000). NicoIetti (1990), afirma que, além das vacinas vivas promoverem imunidade mais completa e duradoura em relação às vacinas mortas por estimular maior ação macrofágica, a estirpe B19 multiplica-se no hospedeiro por períodos limitados e a imunidade conferida é essencialmente do tipo celular.…”

Section: Szyfres 2001)unclassified

Excreção de Brucella abortus, estirpe B19 pelo leite e urina de fêmeas bovinas de diferentes faixas etárias vacinadas contra brucelose e sua relação com o ciclo reprodutivo

Pacheco¹

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Response of Bali cattle (Bos javanicus) to vaccination with Brucella abortus strain 19 in West Timor

Cited by 6 publications

References 10 publications

A case study investigating the effects of emergency vaccination with Brucella abortus A19 vaccine on a dairy farm undergoing an abortion outbreak in China

A case study investigating the effects of emergency vaccination with Brucella abortus A19 vaccine on a dairy farm undergoing an abortion outbreak in China

Brucellosis seroprevalence in Bali cattle with reproductive failure in South Sulawesi and Brucella abortus biovar 1 genotypes in the Eastern Indonesian archipelago

Excreção de Brucella abortus, estirpe B19 pelo leite e urina de fêmeas bovinas de diferentes faixas etárias vacinadas contra brucelose e sua relação com o ciclo reprodutivo

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