Response of Bitot's Spots to a Single Oral 100,000- or 200,000-IU Dose of Vitamin A

Resolution of Bitot's spots following mega-dose vitamin A supplementation in children between 1 and 5 years of age

“…In conformity with earlier reports (6,7,11) , we documented no consistent clinical predictor of non-responsive BS. Minor histopathological differences have however been reported (11) .…”

“…Also in young children, BS is believed to be a more valid clinical indicator than night blindness because it: (i) can be reliably detected by trained paramedical personnel; (ii) is a specific sign for VAD ( 4 ) ; and (iii) is responsive to vitamin A therapy. However, in three small studies in pre-school children conducted two to three decades ago ( 5 – 7 ) , overall 20% (range: 6–36%) of BS did not respond completely to 60 mg retinol equivalent of MVAS. Thus in settings relying on BS to assess VAD prevalence and the success of MVAS programmes, it is important to realize that a fifth of individuals may not be cured of all BS after intervention.…”

Deficiência de vitamina A: relato de caso

“…A boa evolução com regressão da mancha de Bitot, como evidenciado neste caso é referida após reposição de vitamina A, ainda que dose oral única de 100.000 UI, sendo observada maior responsividade a este tratamento nos pacientes com concentração sérica de retinol inicial mais baixa 9 . A administração tópica sob a forma de ácido retinóico tem se mostrado útil como tratamento adjunto da xeroftalmia sendo por isso associada no caso apresentado.…”

Vitamin A Deficiency

“…similar in clinical appearance, factors associated with responsive and nonresponsive X1B differ: The latter are more frequent with age, associated with localized versus more generalized metaplasia and goblet cell loss, less often associated with night blindness, and observed at higher serum retinol concentrations than responsive X1B [300][301][302].…”