1983
DOI: 10.1016/0014-4835(83)90033-7
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Response of bovine intra-ocular muscles to transmural stimulation in the presence of various prostaglandins

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Cited by 17 publications
(19 citation statements)
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“…In view of the fact that the ciliary muscle contains two types of muscle ®bers, longitudinal and circular smooth muscle, EP 1 mRNA might be expressed only in circular ®bers and therefore may not be involved in regulating the tone of the longitudinal muscle ®bers. In fact, ciliary muscle relaxation by PGE 2 has been demonstrated only in the precontracted longitudinal preparations (Suzuki andKobayashi, 1983, Chen andWoodward, 1992;Goh et al, 1995).…”
Section: Discussionmentioning
confidence: 95%
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“…In view of the fact that the ciliary muscle contains two types of muscle ®bers, longitudinal and circular smooth muscle, EP 1 mRNA might be expressed only in circular ®bers and therefore may not be involved in regulating the tone of the longitudinal muscle ®bers. In fact, ciliary muscle relaxation by PGE 2 has been demonstrated only in the precontracted longitudinal preparations (Suzuki andKobayashi, 1983, Chen andWoodward, 1992;Goh et al, 1995).…”
Section: Discussionmentioning
confidence: 95%
“…The stimulation of ciliary muscle with PGs induces relaxation of pre-contracted isolated ciliary muscles (Suzuki and Kobayashi, 1983;Chen and Woodward 1992;Goh, Hotehama and Mishima, 1995). Because the relaxation of ciliary muscle is thought to reduce IOP by causing an increase in the uveoscleral out¯ow of aqueous humor through the widened spaces between the ciliary muscle bundles (Crawford and Kaufman, 1987), it has stimulated great interest to reveal the mechanism for PG-induced ciliary muscle relaxation.…”
Section: Introductionmentioning
confidence: 97%
“…the electrical stimulation and perfusion solu tions were applied at the same time; the strips of iris sphincter and iris dilator were obtained from the same region of the eye (su perior and inferior aspects); the order of iso lation of these muscles had no influence on these experiments [Suzuki and Kobayashi, 1983a], Nevertheless, since these muscles ex hibited marked differences in their response time courses, not only in rising phase, but also in returning to baseline, it is assumed that the obvious difference in their time courses may be a significant factor in the well-regulated reaction of the pupil.…”
Section: Discussionmentioning
confidence: 99%
“…Indomethacin (Sigma) was applied throughout this experiment, unless otherwise stated. Other details have been published elsewhere [Suzuki and Kobayashi, 1983a],…”
Section: Methodsmentioning
confidence: 99%
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