Response of canine bone to a synthetic bone graft material

John, Kenneth R.; Zardiackas, Lyle D.; Black, R.John; Armstrong, R. M.

doi:10.1016/0267-6605(93)90027-5

Cited by 9 publications

(5 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Cell‐mediated resorption is an important process determining the fate of ceramic implants 4, 26, 27. We investigated the appearance of phagocytotic cells around the implants with quantification of the ED1, which is a marker for cells of the monocyte/macrophage lineage and also positive in osteoclasts 28.…”

Section: Discussionmentioning

confidence: 99%

Osteocalcin enhances bone remodeling around hydroxyapatite/collagen composites

Rammelt

Neumann

Hanisch

et al. 2005

J Biomedical Materials Res

View full text Add to dashboard Cite

The effect of osteocalcin (OC), an extracellular bone matrix protein, on bone healing around hydroxyapatite/collagen composites was investigated. Cylindrical nanocrystalline hydroxyapatite implants of 2.5-mm diameter containing 2.5% biomimetically mineralized collagen type I were inserted press-fit into the tibial head of adult Wistar rats. To one implant group, 10 mug/g OC was added. Six specimens per group were analyzed at 2, 7, 14, 28, and 56 days. After 14 days, newly formed woven bone had reached the implant surface of the OC implants whereas a broad fibrous interface could still be observed around controls. Woven bone was formed directly around both implant groups after 28 days and had been replaced partially by lamellar bone around the OC implants only. No significant differences in total bone contact were seen between both groups after 56 days. The higher number of phagocytosing cells and osteoclasts characterized immunohistochemically with ED1, cathepsin D, and tartate-resistant alkaline phosphatase around the OC implants at the early stages of bone healing suggests an earlier onset of bone remodeling. The earlier and increased expression of bone-specific matrix proteins and multifunctional adhesion proteins (osteopontin, bone sialoprotein, CD44) at the interface around the OC implants indicates that OC may accelerate bone formation and regeneration. This study supports the observations from in vitro studies that OC activates both osteoclasts and osteoblasts during early bone formation.

show abstract

Section: Discussionmentioning

confidence: 99%

Osteocalcin enhances bone remodeling around hydroxyapatite/collagen composites

Rammelt

Neumann

Hanisch

et al. 2005

J Biomedical Materials Res

View full text Add to dashboard Cite

show abstract

“…It has been claimed that an optimum balance of the stable phase of HA and the soluble phase of TCP could increase new bone formation, as it releases calcium and phosphate ions into the biological medium (Daculsi et al 2003). While the compound of HA and biphasic TCP show promising results extra‐orally (Russotti et al 1987; Brook et al 1991; St John et al 1993; Emery et al 1996; Gauthier et al 2001; Le Nihouannen et al 2005; Schopper et al 2005; Blouin et al 2006; Fellah et al 2006) and intra‐orally (Hashimoto‐Uoshima et al 1995; Boix et al 2004, 2006) in animal studies, it still lacks validation in intra‐oral applications in humans. Furthermore, in accordance with the available literature, the use of a composite graft of HA/TCP and autogenous bone graft in sinus floor elevation procedures in human patients has not been evaluated.…”

mentioning

confidence: 99%

Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxyapatite/biphasic tricalcium phosphate graft materials: at 6 and 9 months in humans

Artzi

Weinreb

Carmeli

et al. 2008

Clinical Oral Implants Res

View full text Add to dashboard Cite

Objective: The aim of this study was to examine the efficacy of a new biphasic hydroxyapatite/tricalcium phosphate (HA/TCP) bone substitute in combination with particulate autogenous bone in sinus floor augmentation procedures. Material and methods: A simultaneous or a two‐stage sinus augmentation and implant placement were conducted in 28 patients. A mixture of HA/TCP and autogenous bone chips in a 1 : 1 ratio was used as the grafting biomaterial. Cylindrical specimen bone retrieval was performed in all patients except one. Specimens were harvested either at 6 (n=14) or 9 (n=13) months post‐augmentation. For histologic and histomorphometric evaluations, the non‐decalcified tissue processing (Donath's technique) was performed. Results: Newly formed bone around the grafted particles was found in all samples. The encircling, highly cellular bone followed the outline of the grafted particles in direct contact. Both woven and lamellar types of bone were observed. Morphometrically, the total mean bone area fraction of all sections was 34.8±10.3%, increasing from 28.6±7.8% at 6 months to 41.6±8.3% at 9 months (P<0.001). Mean particle area fraction average was 25.5±11.6% and 23.5±9.3% at 6 and 9 months, respectively, with a total mean of 24.5±10.4%. The increase in bone area fraction was not significantly correlated to the decrease of the grafted particles area fraction. Conclusions: The biphasic HA/TCP showed biocompatible and osteoconductive properties. This alloplast as a composite with autogenous bone chips promotes newly formed bone, which increases in its fraction along an extended healing period.

show abstract

“…It has been claimed that an optimum balance of the stable phase of HA and the soluble phase of TCP could increase new bone formation, as it releases calcium and phosphate ions into the biological medium (Daculsi et al 2003). While the compound of HA and biphasic TCP show promising results extra-orally (Russotti et al 1987;Brook et al 1991;St John et al 1993;Emery et al 1996;Gauthier et al 2001;Le Nihouannen et al 2005;Schopper et al 2005;Blouin et al 2006;Fellah et al 2006) and intra-orally (Hashimoto-Uoshima et al 1995;Boix et al 2004Boix et al , 2006 in animal studies, it still lacks validation in intra-oral applications in humans. Furthermore, in accordance with the available literature, the use of a composite graft of HA/TCP and autogenous bone graft in sinus floor elevation procedures in human patients has not been evaluated.…”

mentioning

confidence: 99%