Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxyapatite/biphasic tricalcium phosphate graft materials: at 6 and 9 months in humans

Artzi, Zvi; Weinreb, Miron; Carmeli, Guy; Lev-Dor, Rony; Dard, Michel; Nemcovsky, Carlos E.

doi:10.1111/j.1600-0501.2008.01539.x

Cited by 26 publications

(25 citation statements)

References 41 publications

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“…While newly-formed bone achieved similar outcome (36.1% ± 3.6 and 31.4% ± 1.9, at grafted and non-grafted sites), the non-grafted membrane-protected sites showed greater amount of new cementum (73.9% ± 2.0 vs. 59.5% ± 3.2; p <0.02). It appears that PepGen/P-15 application in membrane-protected defects did not enhance regeneration.Similar findings were obtained in critical size defects (CSD) in the rat skull (Artzi et al 2008). In that study, Pepgen/P15 was applied with and without a GTR membrane while non-grafted membrane-protected and non-protected served as positive and negative controls.…”

Section: Growth and Differentiation Factors For Alveolar Ridge Augmensupporting

confidence: 60%

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Augmentation and Preservation of the Alveolar Process and Alveolar Ridge of Bone

Tal¹,

Artzi²,

Kolerman³

et al. 2012

Bone Regeneration

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Section: Growth and Differentiation Factors For Alveolar Ridge Augmensupporting

confidence: 60%

“…To evaluate HA/TCP with autogenous particulate cancellous bone, this composite graft combination was examined in sinus augmentation procedures (Artzi et al 2008). Newly formed bone around the grafted particles was found in all samples.…”

Section: Biomaterials For Guided Bone Regeneration In the Jaws -Animamentioning

confidence: 99%

Augmentation and Preservation of the Alveolar Process and Alveolar Ridge of Bone

Tal¹,

Artzi²,

Kolerman³

et al. 2012

Bone Regeneration

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“…Another study on sinus grafting (Artzi et al 2008) showed an average of 34.8 AE 10.3% newly formed bone using BCP: HA/TCP 60/40 and autogenous bone particles in a 1 : 1 mixture. However, histomorphometric results showed a remarkable trend regarding the composition of the biopsies analyzed.…”

Section: Discussionmentioning

confidence: 99%

Ridge augmentation and maxillary sinus grafting with a biphasic calcium phosphate: histologic and histomorphometric observations

Friedmann

Dard

Kleber

et al. 2009

Clinical Oral Implants Res

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“…The explants were decalcified for at least 30 days in 14% EDTA [64]–[67] and placed overnight in 30% sucrose-PBS before freezing. Each explant was completely sectioned at 10 µm of thickness.…”

Section: Methodsmentioning

confidence: 99%

Synthetic Bone Substitute Engineered with Amniotic Epithelial Cells Enhances Bone Regeneration after Maxillary Sinus Augmentation

et al. 2013

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BackgroundEvidence has been provided that a cell-based therapy combined with the use of bioactive materials may significantly improve bone regeneration prior to dental implant, although the identification of an ideal source of progenitor/stem cells remains to be determined.AimIn the present research, the bone regenerative property of an emerging source of progenitor cells, the amniotic epithelial cells (AEC), loaded on a calcium-phosphate synthetic bone substitute, made by direct rapid prototyping (rPT) technique, was evaluated in an animal study.Material And MethodsTwo blocks of synthetic bone substitute (∼0.14 cm3), alone or engineered with 1×106 ovine AEC (oAEC), were grafted bilaterally into maxillary sinuses of six adult sheep, an animal model chosen for its high translational value in dentistry. The sheep were then randomly divided into two groups and sacrificed at 45 and 90 days post implantation (p.i.). Tissue regeneration was evaluated in the sinus explants by micro-computer tomography (micro-CT), morphological, morphometric and biochemical analyses.Results And ConclusionsThe obtained data suggest that scaffold integration and bone deposition are positively influenced by allotransplantated oAEC. Sinus explants derived from sheep grafted with oAEC engineered scaffolds displayed a reduced fibrotic reaction, a limited inflammatory response and an accelerated process of angiogenesis. In addition, the presence of oAEC significantly stimulated osteogenesis either by enhancing bone deposition or making more extent the foci of bone nucleation. Besides the modulatory role played by oAEC in the crucial events successfully guiding tissue regeneration (angiogenesis, vascular endothelial growth factor expression and inflammation), data provided herein show that oAEC were also able to directly participate in the process of bone deposition, as suggested by the presence of oAEC entrapped within the newly deposited osteoid matrix and by their ability to switch-on the expression of a specific bone-related protein (osteocalcin, OCN) when transplanted into host tissues.

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Histomorphometric assessment of bone formation in sinus augmentation utilizing a combination of autogenous and hydroxyapatite/biphasic tricalcium phosphate graft materials: at 6 and 9 months in humans

Abstract: The biphasic HA/TCP showed biocompatible and osteoconductive properties. This alloplast as a composite with autogenous bone chips promotes newly formed bone, which increases in its fraction along an extended healing period.

Cited by 26 publications

References 41 publications

Augmentation and Preservation of the Alveolar Process and Alveolar Ridge of Bone

Augmentation and Preservation of the Alveolar Process and Alveolar Ridge of Bone

Ridge augmentation and maxillary sinus grafting with a biphasic calcium phosphate: histologic and histomorphometric observations

Synthetic Bone Substitute Engineered with Amniotic Epithelial Cells Enhances Bone Regeneration after Maxillary Sinus Augmentation

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