Response of cytotoxin production ability to gene expression and cell molecular structure of Microcystis aeruginosa FACHB-905

Ni, Lixiao; Li, Yan; Li, Xianglan; Xu, Chuang; Du, Cunhao; Wu, Hanqi; Li, Shiyin

doi:10.1007/s11356-023-25218-y

Cited by 1 publication

(4 citation statements)

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“…It is worth noting that inactive D1 protein could be replaced by newly synthesized D1 protein, a repair mechanism. 6 Given the direct binding of CLA with the D1 protein, we conclude that CLA interferes with the normal functioning of PSII and limits reaction center repair.…”

Section: ■ Discussionmentioning

confidence: 78%

“…The binding affinities of CLA and the central proteins of PSII (Figure ; Table S4) demonstrate that CLA likely fits into the active sites of D1 and D2. It is worth noting that inactive D1 protein could be replaced by newly synthesized D1 protein, a repair mechanism . Given the direct binding of CLA with the D1 protein, we conclude that CLA interferes with the normal functioning of PSII and limits reaction center repair.…”

Section: Discussionmentioning

confidence: 87%

“…5 Microcystis aeruginosa is one of the most widely distributed algae, which plays a crucial role in the aquatic environment. 6 As primary producers, algae's photosynthetic activity aerates the aquatic ecosystem. 7 In addition, M. aeruginosa is sensitive to antibiotics associated with environmental stress.…”

Section: ■ Introductionmentioning

confidence: 99%

“…Algae are essential component of aquatic ecosystems Microcystis aeruginosa is one of the most widely distributed algae, which plays a crucial role in the aquatic environment . As primary producers, algae’s photosynthetic activity aerates the aquatic ecosystem .…”

Section: Introductionmentioning

confidence: 99%

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Repeated Exposure Enhanced Toxicity of Clarithromycin on Microcystis aeruginosa Versus Single Exposure through Photosynthesis, Oxidative Stress, and Energy Metabolism Shift

Mao,

Ye,

Yang

et al. 2024

Environ. Sci. Technol.

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Antibiotics are being increasingly detected in aquatic environments, and their potential ecological risk is of great concern. However, most antibiotic toxicity studies involve single-exposure experiments. Herein, we studied the effects and mechanisms of repeated versus single clarithromycin (CLA) exposure on Microcystis aeruginosa. The 96 h effective concentration of CLA was 13.37 μg/L upon single exposure but it reduced to 6.90 μg/L upon repeated exposure. Single-exposure CLA inhibited algal photosynthesis by disrupting energy absorption, dissipation and trapping, reaction center activation, and electron transport, thereby inducing oxidative stress and ultrastructural damage. In addition, CLA upregulated glycolysis, pyruvate metabolism, and the tricarboxylic acid cycle. Repeated exposure caused stronger inhibition of algal growth via altering photosynthetic pigments, reaction center subunits biosynthesis, and electron transport, thereby inducing more substantial oxidative damage. Furthermore, repeated exposure reduced carbohydrate utilization by blocking the pentose phosphate pathway, consequently altering the characteristics of extracellular polymeric substances and eventually impairing the defense mechanisms of M. aeruginosa. Risk quotients calculated from repeated exposure were higher than 1, indicating significant ecological risks. This study elucidated the strong influence of repeated antibiotic exposure on algae, providing new insight into antibiotic risk assessment.

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Section: ■ Discussionmentioning

confidence: 78%

Section: Discussionmentioning

confidence: 87%