Response of different types of connective tissue to hormones

Kasavina, B. S.; Torbenko, V. P.; Ukhina, T. V.

doi:10.1007/bf00798517

Cited by 4 publications

(3 citation statements)

References 3 publications

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“…5a) with a pore size ranging from 1 to 3 µm and a characteristic surface morphology. According to earlier reports [1,2,23], such pore structures of OMCs are best suited for the interaction of OMC-based implants with tissue and contribute to the stabilization of HA in implants.…”

Section: Resultsmentioning

confidence: 97%

“…Even though autogenic implants offer a number of advantages, their application in prosthetics requires surgical procedures for taking bone grafts. At the same time, the use of allogenic bone graft materials involves the risks of infection and immune reactions, which may impede healing and carry a health hazard [2]. Even biocompatible implant materials are subject to the influence of fibrous tissue, resulting in their encapsulation, which impedes adhesion and may lead to bioactivity loss and isolation of the implant from the surrounding bone tissue [3].…”

Section: Introductionmentioning

confidence: 99%

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Hydroxyapatite-Carboxymethyl Cellulose Nanocomposite Biomaterial

et al. 2005

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An organic-mineral composite of hydroxyapatite (Ca 10 (PO 4 ) 6 (OH) 2 ) nanoparticles and carboxymethyl cellulose (CMC) is synthesized via coprecipitation from a solution containing CaCl 2 , aqueous ammonia, (NH 4 ) 2 HPO 4 , and CMC. The composition and microstructure of the composite and the lattice parameters and particle size of the hydroxyapatite are determined using x-ray diffraction, chemical analysis, IR spectroscopy, scanning and transmission electron microscopy techniques, electron diffraction, and x-ray microanalysis. The hydroxyapatite nanoparticles are shown to form agglomerates about 200 nm in size. The interaction between the nanoparticles and CMC macromolecules leads to the formation of a pore structure potentially attractive for biomedical applications.

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Section: Resultsmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 99%

Hydroxyapatite-Carboxymethyl Cellulose Nanocomposite Biomaterial

et al. 2005

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“…A 1977 study found that GH affected lysosomal glycosidase activity of the sclera and cornea. 87 Recently, human studies have shown altered thickness and biomechanics of the cornea in acromegalic patients and GH-deficient children. 88–90 These findings suggest a role of GH in the cornea.…”

Section: Treatment Of Persistent Corneal Epithelial Defectsmentioning

confidence: 99%

Novel Therapy to Treat Corneal Epithelial Defects: A Hypothesis with Growth Hormone

et al. 2015

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Impaired corneal wound healing that occurs with ocular surface disease, trauma, systemic disease, or surgical intervention can lead to persistent corneal epithelial defects (PCED), which result in corneal scarring, ulceration, opacification, corneal neovascularization, and, ultimately, visual compromise and vision loss. The current standard of care can include lubricants, ointments, bandage lenses, amniotic membranes, autologous serum eye drops, and corneal transplants. Various inherent problems exist with application and administration of these treatments, which often may not result in a completely healed surface. A topically applicable compound capable of promoting corneal epithelial cell proliferation and/or migration would be ideal to accelerate healing. We hypothesize that human growth hormone (HGH) is such a compound. In a recent study, HGH was shown to activate signal transducer and activators of transcription-5 (STAT5) signaling and promote corneal wound healing by enhancing corneal epithelial migration in a co-culture system of corneal epithelial cells and fibroblasts. These effects require an intact communication between corneal epithelia and fibroblasts. Further, HGH promotes corneal wound healing in a rabbit debridement model, thus demonstrating the effectiveness of HGH in vivo as well. In conclusion, HGH may represent an exciting and effective topical therapeutic to promote corneal wound healing.

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Regulation of Cartilage Acid Hydrolases by Growth Hormone*

Hubbard

Liberti

1982

Endocrinology

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The in vivo regulation of three acid hydrolases, namely cathepsin D, cathepsin B, and acid phosphatase, by GH was investigated. The costal cartilage cathepsin D and acid phosphatase activities of hypophysectomized rats were reduced relative to those found in normal controls. Treatment of hypophysectomized animals with GH enhanced rat growth rate and increased these two enzyme activities toward normal levels. Results of pepstatin experiments suggested that the elevated cartilage cathepsin D activity corresponded to an increase in enzyme concentration. A degree of specificity in this regulation was apparent because cartilage cathepsin B, unlike cathepsin D and acid phosphatase, was refractory to hypophysectomy and GH treatment. In contradistinction to cartilage, none of these hepatic enzymes responded to GH, and only cathepsin B activity was diminished by hypophysectomy. Centrifugational and detergent studies indicated that changes in enzyme activities induced by GH treatment were not due to the differential release of acid hydrolases from subcellular compartments. Overall, our results suggest that costal cartilage cathepsin D and acid phosphatase activities are GH dependent and may be related to cartilage growth. These observations may provide insight into the mechanism of GH action and, derivatively, skeletal growth.

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Response of different types of connective tissue to hormones

Cited by 4 publications

References 3 publications

Hydroxyapatite-Carboxymethyl Cellulose Nanocomposite Biomaterial

Hydroxyapatite-Carboxymethyl Cellulose Nanocomposite Biomaterial

Novel Therapy to Treat Corneal Epithelial Defects: A Hypothesis with Growth Hormone

Regulation of Cartilage Acid Hydrolases by Growth Hormone*

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