Response of EP and cochlear blood flow to angiotensin II during hypoxic condition

Yamamoto, Hirofumi; Makimoto, Kazuo

doi:10.1016/s0385-8146(98)00037-6

Cited by 3 publications

(2 citation statements)

References 20 publications

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“…From the standpoint of an initial hypothesis about the role of hypotension in the genesis of unexplained cases of acute sensorineural hearing loss in young subjects, regardless to the shape of the audiometric curve [23,24], a series of studies were carried out: the aim was to verify the possibility of an adverse effect on the cochlea derived from an abrupt lowering of blood pressure values and a subsequent exaggerated vasomotor response inducing local ischemia. Actually the inner ear, due both to its terminal vascular supply and to its energy-requiring metabolism, seems a reliable target for any hemodynamic imbalance that acutely affects its perfusion: the correlation between endocochlear potential and cochlear blood flow [25] supports this statement. Moreover, the not negligible representation of perivascular adrenergic fibers [26] can reasonably back up the possibility of a prominent sympathetic drive in response to transient hypoperfusion, in agreement with the classical experimental models of Hultcrantz [27] and Maass [28].…”

Section: How the Indiscriminate Use Of Diuretics Could Damage The Inn...mentioning

confidence: 92%

Diuretics in Meniere disease: A therapy or a potential cause of harm?

et al. 2011

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Section: How the Indiscriminate Use Of Diuretics Could Damage The Inn...mentioning

confidence: 92%

Diuretics in Meniere disease: A therapy or a potential cause of harm?

et al. 2011

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“…51 Previous studies demonstrated significant reductions in endocochlear potentials and intracochlear blood flow at the basal turn cochlea during induced hypoxemia. 4,52 However, caution should be taken when comparing differences between these groups as the confidence intervals of the midfrequency range and the high-frequency range overlap and are wider in the high-frequency group. In addition, both analyses had high heterogeneity.…”

Section: Discussionmentioning

confidence: 99%

Obstructive Sleep Apnea and Sensorineural Hearing Loss: A Systematic Review and Meta‐analysis

Kasemsuk

Chayopasakul

Banhiran

et al. 2022

Otolaryngol.--head neck surg.

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Objectives To evaluate the associations between obstructive sleep apnea (OSA) and sensorineural hearing loss (SNHL) and the effects of continuous positive airway pressure (CPAP) therapy on SNHL. Data Sources Ovid Medline, Embase, and Scopus databases. Review Methods A systematic search was done for studies investigating relationships between OSA and SNHL in adults, with manual searches for additional references. The final update was done on December 22, 2021. The Risk of Bias Assessment Tool for Nonrandomized Studies was applied for quality assessments. Results The 20 included studies had a total of 34,442 participants (66% male; mean age, 46.6 years). The OSA group had a significantly worse mean hearing threshold level (HTL) than the control group for midfrequency ranges (500, 1000, 2000 Hz; mean difference, 4.00 dB; 95% CI, 2.40-5.61) and high-frequency ranges (4000, 8000 Hz; mean difference, 6.24 dB; 95% CI, 2.99-9.49). An association between OSA and SNHL was found. When compared with controls, patients with OSA had an odds ratio of 1.52 (95% CI, 1.12-2.06) for midfrequency hearing impairment and 1.19 (95% CI, 1.05-1.34) for high-frequency hearing impairment. However, we did not find significant improvements in midfrequency HTL after CPAP therapy. Conclusions HTL was significantly poorer among participants with OSA (especially in severe cases) than non-OSA controls. Studies on patients with OSA with SNHL treated with CPAP did not show significant improvements in midfrequency HTL. Further studies are warranted on these issues.

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Morphological and functional structure of the inner ear: Its relation to Ménière's disease

Olivetto

Simoni

Guaran

et al. 2012

Audiological Medicine

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Ménière's disease is a disabling disorder presenting with crises of aural fullness, tinnitus, hearing loss and vertigo. The hallmark of the pathology is a labyrinthine hydrops, but its pathogenesis remains unclear. This unknown aetiology explains the lack of a good pharmacological treatment. Here, we wish to evaluate the different parameters that can be involved in the progression of the disease, focusing on vascular disorders, production of reactive oxygen species and the relationship between the endolymph and haematic perfusion. We know that the blood supply must be adequate to guarantee the establishment of the endocochlear potential and the production of endolymph, so aberrant microcirculation may be an aetiological factor for Méniè re's disease. © 2012 Informa Healthcare

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Response of EP and cochlear blood flow to angiotensin II during hypoxic condition

Cited by 3 publications

References 20 publications

Diuretics in Meniere disease: A therapy or a potential cause of harm?

Diuretics in Meniere disease: A therapy or a potential cause of harm?

Obstructive Sleep Apnea and Sensorineural Hearing Loss: A Systematic Review and Meta‐analysis

Morphological and functional structure of the inner ear: Its relation to Ménière's disease

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